ID   COG4_PONAB              Reviewed;         785 AA.
AC   Q5R7R6;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 4;
DE            Short=COG complex subunit 4;
DE   AltName: Full=Component of oligomeric Golgi complex 4;
GN   Name=COG4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for normal Golgi function. Plays a role in SNARE-pin
CC       assembly and Golgi-to-ER retrograde transport via its interaction with
CC       SCFD1. {ECO:0000250|UniProtKB:Q9H9E3}.
CC   -!- SUBUNIT: Monomer. Component of the conserved oligomeric Golgi (COG)
CC       complex which is composed of eight different subunits and is required
CC       for normal Golgi morphology and localization. Mediates interaction of
CC       SCFD1 with the COG complex. Interacts with STX5.
CC       {ECO:0000250|UniProtKB:Q9H9E3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9H9E3}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9H9E3}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9H9E3}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q9H9E3}.
CC   -!- SIMILARITY: Belongs to the COG4 family. {ECO:0000305}.
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DR   EMBL; CR860044; CAH92194.1; -; mRNA.
DR   RefSeq; NP_001126284.1; NM_001132812.1.
DR   AlphaFoldDB; Q5R7R6; -.
DR   SMR; Q5R7R6; -.
DR   STRING; 9601.ENSPPYP00000008512; -.
DR   GeneID; 100173259; -.
DR   KEGG; pon:100173259; -.
DR   CTD; 25839; -.
DR   eggNOG; KOG0412; Eukaryota.
DR   InParanoid; Q5R7R6; -.
DR   OrthoDB; 376278at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR013167; COG_su4.
DR   Pfam; PF08318; COG4; 1.
DR   SMART; SM00762; Cog4; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Golgi apparatus; Membrane; Phosphoprotein;
KW   Protein transport; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT   CHAIN           2..785
FT                   /note="Conserved oligomeric Golgi complex subunit 4"
FT                   /id="PRO_0000339133"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2..84
FT                   /note="Interaction with SCFD1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT   REGION          85..153
FT                   /note="Interaction with STX5"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT   REGION          618..740
FT                   /note="D domain"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT   REGION          741..785
FT                   /note="E domain; essential for proper cell surface
FT                   glycosylation"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9E3"
FT   MOD_RES         6
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H9E3"
SQ   SEQUENCE   785 AA;  89171 MW;  A0D912B8CDD8ABD2 CRC64;
     MADFDSPPKL SGVQPPSEGV GGGRCSEISA ELIRSLTELQ ELETVYERLC GEEKVVEREL
     DALLEQQNTI ESKMVTLHRM GPNLQLIEGD AKQLAGMITF TCNLAENVSS KVRQLDLAKN
     RLYQAIQRAD DILDLKFCMD GVQTALRNED YEQAAAHIHR YLCLDKSVIE LSRQGKEGSM
     IDANLKLLQE AEQRLKAIVA EKFAVATKEG DLPQVERFFK IFPLLGLHEE GLRKFSEYLC
     KQVASKAEEN LLMVLGTDMS DRRAAVIFAD TLTLLFEGIA RIVETHQPIV ETYYGPGRLY
     TLIKYLQVEC DRQVEKVVDK FIKQRDYHQQ FRHVQNNLMR NSTTEKIEPR ELDPILTEVT
     LMNARSELYL RFLKKRISSD FEVGDSMASE EVKQEHQKCL DKLLNNCLLS CTMQELIGLY
     VTMEEYFMRE TVNKAVALDT YEKGQLTSSM VDDVFYIVKK CIGRALSSSS IDCLCAMINL
     ATTELESDFR DVLCNKLRMG FPATTFQDIQ RGVTSAVNIM HSSLQQGKFD TKGIESTDEA
     KMSFLVTLNN VEVCSENIST LKKTLESDCT KLFSQGIGGE QAQAKFDSCL SDLAAVSNKF
     RDLLQEGLTE LNSTAIKPQV QPWINSFFSV SHNIEEEEFN DYEANDPWVQ QFILNLEQQM
     AEFKASLSPV IYDSLTGLMT SLVTVELEKV VLKSTFNRLG GLQFDKELRS LIAYLTTVTT
     WTIRDKFARL SQMATILNLE RVTEILDYWG PNSGPLTWRL TPAEVRQVLA LRIDFRSEDI
     KRLRL