COG4_YEAST
ID COG4_YEAST Reviewed; 861 AA.
AC Q06096; D6W4A3;
DT 30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 4;
DE Short=COG complex subunit 4;
DE AltName: Full=Component of oligomeric Golgi complex 4;
DE AltName: Full=Protein SEC38;
GN Name=COG4; Synonyms=SEC38, SGF1; OrderedLocusNames=YPR105C;
GN ORFNames=P8283.16;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBUNIT.
RX PubMed=11703943; DOI=10.1016/s1534-5807(01)00063-6;
RA Whyte J.R., Munro S.;
RT "The Sec34/35 Golgi transport complex is related to the exocyst, defining a
RT family of complexes involved in multiple steps of membrane traffic.";
RL Dev. Cell 1:527-537(2001).
RN [5]
RP IDENTIFICATION IN THE COG COMPLEX.
RX PubMed=11733049; DOI=10.1034/j.1600-0854.2001.21111.x;
RA Kim D.W., Massey T., Sacher M., Pypaert M., Ferro-Novick S.;
RT "Sgf1p, a new component of the Sec34p/Sec35p complex.";
RL Traffic 2:820-830(2001).
RN [6]
RP IDENTIFICATION IN THE COG COMPLEX, AND FUNCTION OF THE COG COMPLEX.
RX PubMed=12011112; DOI=10.1083/jcb.200111081;
RA Suvorova E.S., Duden R., Lupashin V.V.;
RT "The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-
RT Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat
RT proteins.";
RL J. Cell Biol. 157:631-643(2002).
RN [7]
RP FUNCTION, AND IDENTIFICATION IN THE COG COMPLEX.
RX PubMed=12006647; DOI=10.1091/mbc.01-10-0495;
RA Ram R.J., Li B., Kaiser C.A.;
RT "Identification of sec36p, sec37p, and sec38p: components of yeast complex
RT that contains sec34p and sec35p.";
RL Mol. Biol. Cell 13:1484-1500(2002).
RN [8]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [9]
RP COMPOSITION OF THE COG COMPLEX, AND INTERACTION WITH COG1; COG2; COG5 AND
RP COG7.
RX PubMed=15047703; DOI=10.1074/jbc.m400662200;
RA Loh E., Hong W.;
RT "The binary interacting network of the conserved oligomeric Golgi tethering
RT complex.";
RL J. Biol. Chem. 279:24640-24648(2004).
CC -!- FUNCTION: Acts as essential component of the peripheral membrane COG
CC complex that is involved in intra-Golgi protein trafficking. COG is
CC located at the cis-Golgi, and regulates tethering of retrograde intra-
CC Golgi vesicles and possibly a number of other membrane trafficking
CC events. Possesses ATPase activity. {ECO:0000269|PubMed:12006647,
CC ECO:0000269|PubMed:12011112}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi (COG or
CC Sec34/Sec35) complex which consists of eight different proteins COG1-
CC COG8. {ECO:0000269|PubMed:11703943, ECO:0000269|PubMed:11733049,
CC ECO:0000269|PubMed:12006647, ECO:0000269|PubMed:12011112}.
CC -!- INTERACTION:
CC Q06096; P53079: COG1; NbExp=9; IntAct=EBI-4823, EBI-4835;
CC Q06096; P53271: COG2; NbExp=15; IntAct=EBI-4823, EBI-16614;
CC Q06096; P40094: COG3; NbExp=4; IntAct=EBI-4823, EBI-16605;
CC Q06096; P53951: COG5; NbExp=4; IntAct=EBI-4823, EBI-4841;
CC Q06096; P53195: COG7; NbExp=2; IntAct=EBI-4823, EBI-4847;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9H9E3}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9H9E3}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q9H9E3}.
CC -!- MISCELLANEOUS: Present with 1620 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the COG4 family. {ECO:0000305}.
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DR EMBL; U32445; AAB68075.1; -; Genomic_DNA.
DR EMBL; AY692743; AAT92762.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11519.1; -; Genomic_DNA.
DR PIR; S59770; S59770.
DR RefSeq; NP_015430.1; NM_001184202.1.
DR AlphaFoldDB; Q06096; -.
DR BioGRID; 36271; 589.
DR ComplexPortal; CPX-1840; COG Golgi transport complex.
DR DIP; DIP-2003N; -.
DR IntAct; Q06096; 26.
DR MINT; Q06096; -.
DR STRING; 4932.YPR105C; -.
DR iPTMnet; Q06096; -.
DR MaxQB; Q06096; -.
DR PaxDb; Q06096; -.
DR PRIDE; Q06096; -.
DR EnsemblFungi; YPR105C_mRNA; YPR105C; YPR105C.
DR GeneID; 856220; -.
DR KEGG; sce:YPR105C; -.
DR SGD; S000006309; COG4.
DR VEuPathDB; FungiDB:YPR105C; -.
DR eggNOG; KOG0412; Eukaryota.
DR GeneTree; ENSGT00940000154065; -.
DR HOGENOM; CLU_014853_3_0_1; -.
DR InParanoid; Q06096; -.
DR OMA; FLVKFMQ; -.
DR BioCyc; YEAST:G3O-34245-MON; -.
DR PRO; PR:Q06096; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q06096; protein.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0000139; C:Golgi membrane; IC:ComplexPortal.
DR GO; GO:0017119; C:Golgi transport complex; IMP:SGD.
DR GO; GO:0030242; P:autophagy of peroxisome; IMP:SGD.
DR GO; GO:0032258; P:cytoplasm to vacuole transport by the Cvt pathway; IMP:SGD.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IMP:SGD.
DR GO; GO:0016236; P:macroautophagy; IMP:SGD.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; IMP:SGD.
DR InterPro; IPR013167; COG_su4.
DR Pfam; PF08318; COG4; 1.
DR SMART; SM00762; Cog4; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..861
FT /note="Conserved oligomeric Golgi complex subunit 4"
FT /id="PRO_0000213508"
SQ SEQUENCE 861 AA; 98666 MW; 22F265AB2AD91533 CRC64;
MEGQKSNASW ESSIIEGQLS KNLARYTLLL DKLSTLSQID KLSEVIANDY AKQSKQLNAF
VQQSQSSLNK ESRKLELQRT NLTTTLTQFH ETVATISSSN ARAKAIHDDI ETVDQERALV
NKTLQFVKDV RTLKNNISLA HSALETKDYL VAATAINEIR SLPDKKLIVS EFAKKVVPSS
EIPEEPAILI KNWCKELTSL FQEQFMEATR TQDIKELTLM FKMFPMIGQD VLGLDLYSKY
VCDIIADESR KIMSNSMENS TKFQGFFSQV LLHLFKIVST IINDHSKVIA TCYGKKHMVH
VMEKVEKEAD LQASLILDIF METRKIERTI HDINEWEHSQ KNEDVNIDSN QSDIETDGET
EKSSIISIHD LALLIMEFSQ ILQNWSMYSR FYSVKWNEFS DLHPHVLQPP PPIADGKFAL
KLKQDKVFDE FQVFVLNHLQ RSFRNSISLE ELPSLNDLIT AVPLNDHDNI SYPVTSVLDD
LILLVRKNLI SVVNTGQFKL LASFLNELVK FFQNRFLVKF MQNKFKLLQS KLASNVSLKR
YIPKGEEQSA TSRSVSPPAN KFSPLSRFTF RGAAASALTN IQSNLQAVVA EDEDSILALH
HYLIYLNTLY LSKVYVHRLL SIEILEDDSQ RILRDNFPFD NDAAQLQNLI INSEKLVLEQ
TDKLSKWAVK YLFQNILQNR VRNLLGTVFV NSASSNSSTS NQKNVSRDYS AGSNQKNYIT
SIEDFEDLSQ INSFNSKWNQ LIIPYKNILH NEAYAELLSV IVDYIVTTLE QRIWTLEFNE
LGVTKLDREL SLFIGNMCGL NYNLREKFLK LTQIVLLLGL DDDNFDLTTG DIKDDFNGTF
DWVINSQERI KARNMKIDRT Q
