COG5_ARATH
ID COG5_ARATH Reviewed; 832 AA.
AC Q9C9V9;
DT 13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 5 {ECO:0000303|PubMed:27448097};
DE Short=COG complex subunit 5 {ECO:0000303|PubMed:27448097};
DE AltName: Full=Component of oligomeric Golgi complex 5 {ECO:0000303|PubMed:27448097};
GN Name=COG5 {ECO:0000303|PubMed:27448097};
GN OrderedLocusNames=At1g67930 {ECO:0000312|Araport:AT1G67930};
GN ORFNames=T23K23.22 {ECO:0000312|EMBL:AAG52007.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP SUBUNIT, INTERACTION WITH COG3; COG6; COG7 AND COG8, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=27448097; DOI=10.1371/journal.pgen.1006140;
RA Tan X., Cao K., Liu F., Li Y., Li P., Gao C., Ding Y., Lan Z., Shi Z.,
RA Rui Q., Feng Y., Liu Y., Zhao Y., Wu C., Zhang Q., Li Y., Jiang L., Bao Y.;
RT "Arabidopsis COG complex subunits COG3 and COG8 modulate golgi morphology,
RT vesicle trafficking homeostasis and are essential for pollen tube growth.";
RL PLoS Genet. 12:E1006140-E1006140(2016).
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000250|UniProtKB:Q9VJD3}.
CC -!- SUBUNIT: Homodimer (PubMed:27448097). Component of the conserved
CC oligomeric Golgi complex which is composed of eight different subunits
CC and is required for normal Golgi morphology and localization
CC (Probable). Interacts with COG3, COG6, COG7 and COG8 (PubMed:27448097).
CC {ECO:0000269|PubMed:27448097, ECO:0000305|PubMed:27448097}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9VJD3}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9VJD3}.
CC -!- SIMILARITY: Belongs to the COG5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC012563; AAG52007.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34723.1; -; Genomic_DNA.
DR PIR; B96702; B96702.
DR RefSeq; NP_176960.1; NM_105463.4.
DR AlphaFoldDB; Q9C9V9; -.
DR IntAct; Q9C9V9; 1.
DR STRING; 3702.AT1G67930.1; -.
DR iPTMnet; Q9C9V9; -.
DR PaxDb; Q9C9V9; -.
DR PRIDE; Q9C9V9; -.
DR ProteomicsDB; 185077; -.
DR EnsemblPlants; AT1G67930.1; AT1G67930.1; AT1G67930.
DR GeneID; 843121; -.
DR Gramene; AT1G67930.1; AT1G67930.1; AT1G67930.
DR KEGG; ath:AT1G67930; -.
DR Araport; AT1G67930; -.
DR TAIR; locus:2200246; AT1G67930.
DR eggNOG; KOG2211; Eukaryota.
DR HOGENOM; CLU_009839_1_1_1; -.
DR InParanoid; Q9C9V9; -.
DR OMA; KSFDECP; -.
DR OrthoDB; 871605at2759; -.
DR PhylomeDB; Q9C9V9; -.
DR PRO; PR:Q9C9V9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C9V9; baseline and differential.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR019465; Cog5.
DR PANTHER; PTHR13228; PTHR13228; 1.
DR Pfam; PF10392; COG5; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Reference proteome.
FT CHAIN 1..832
FT /note="Conserved oligomeric Golgi complex subunit 5"
FT /id="PRO_0000448527"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 91651 MW; E6BA745D487382B6 CRC64;
MALPPSSPSP SSPSLQRLST FKNPPPSSLS SGAPPPQTPS SSSSSPLDSF ATDPILSPFL
SSSFSSASFS SAALASGSPA STAERLHQAI RLLDSQLRND VISRHPELLA QLSSLSHADV
SLSSLRSSVS SLQSSIRRVR SDLSEPIKSI RSKSVQLSNL HTATELLSHS VRTLRLSKKL
RDLADFPDPD KIDLTKAAQF HFEILTMCKE YDLFGIDVID EEIKFVTEIG EKLRSEAMKV
LERGMEGLNQ AEVGTGLQVF YNLGELKSTV DQLVNKYKGM AVKSVSVAMD MKAITSGSGG
GFGPGGIRSS GSPHIGGGAK VREALWQRMA SCMEQLCSLV VAVWHLQRVL SKKRDPFTHV
LLLDEVIKEG DSMLTDRVWD ALVKAFTSQM KSAYTASSFV KEIFTMGYPK LVSMIENLLE
RISRDTDVKG VLPAINLERK EQMVACIAIF QTAFLSLCFG RLSDLVNSIF PMSSRGSLPS
KEQISQVLSH IQDEIEAVHP DARLTLLVLR EIGKALSNLA QRAECQISTG PETRQISGPA
TSTQIRNFTL CQHLQGIHTH ISSMVADLPS IATDVLSPYL AAIYDAACEP VTPLFKAMRD
KLESCILQIH DQNFGADDAD MDNNASSYME ELQRSILHFR KEFLSRLLPS AANANTAGTE
SICTRLTRQM ASRVLIFYIR HASLVRPLSE WGKLRMAKDM AELELAVGQN LFPVEQLGAP
YRALRAFRPL VFLETSQMGS SPLINDLPPS IVLHHLYTRG PDELESPMQK NRLSPKQYSL
WLDNQREDQI WKGIKATLDD YAVKIRSRGD KEFSPVYPLM LQIGSSLTQE NL
