COG5_MOUSE
ID COG5_MOUSE Reviewed; 829 AA.
AC Q8C0L8; E9QM30;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 5;
DE Short=COG complex subunit 5;
DE AltName: Full=Component of oligomeric Golgi complex 5;
GN Name=Cog5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for normal Golgi function. {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Golgi apparatus
CC membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC27065.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK030656; BAC27065.1; ALT_INIT; mRNA.
DR EMBL; AC119950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC125020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT010463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS49046.1; -.
DR RefSeq; NP_001156598.1; NM_001163126.1.
DR RefSeq; XP_011242170.1; XM_011243868.2.
DR AlphaFoldDB; Q8C0L8; -.
DR STRING; 10090.ENSMUSP00000044797; -.
DR iPTMnet; Q8C0L8; -.
DR PhosphoSitePlus; Q8C0L8; -.
DR EPD; Q8C0L8; -.
DR MaxQB; Q8C0L8; -.
DR PaxDb; Q8C0L8; -.
DR PeptideAtlas; Q8C0L8; -.
DR PRIDE; Q8C0L8; -.
DR ProteomicsDB; 283488; -.
DR Antibodypedia; 17176; 50 antibodies from 15 providers.
DR Ensembl; ENSMUST00000036862; ENSMUSP00000044797; ENSMUSG00000035933.
DR GeneID; 238123; -.
DR KEGG; mmu:238123; -.
DR UCSC; uc007nhs.1; mouse.
DR CTD; 10466; -.
DR MGI; MGI:2145130; Cog5.
DR VEuPathDB; HostDB:ENSMUSG00000035933; -.
DR eggNOG; KOG2211; Eukaryota.
DR GeneTree; ENSGT00390000004586; -.
DR HOGENOM; CLU_009839_1_0_1; -.
DR InParanoid; Q8C0L8; -.
DR OMA; KSFDECP; -.
DR OrthoDB; 871605at2759; -.
DR PhylomeDB; Q8C0L8; -.
DR TreeFam; TF313139; -.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR Reactome; R-MMU-6811438; Intra-Golgi traffic.
DR Reactome; R-MMU-6811440; Retrograde transport at the Trans-Golgi-Network.
DR BioGRID-ORCS; 238123; 19 hits in 76 CRISPR screens.
DR ChiTaRS; Cog5; mouse.
DR PRO; PR:Q8C0L8; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8C0L8; protein.
DR Bgee; ENSMUSG00000035933; Expressed in undifferentiated genital tubercle and 252 other tissues.
DR ExpressionAtlas; Q8C0L8; baseline and differential.
DR Genevisible; Q8C0L8; MM.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0070085; P:glycosylation; ISO:MGI.
DR GO; GO:0007030; P:Golgi organization; ISO:MGI.
DR GO; GO:0048219; P:inter-Golgi cisterna vesicle-mediated transport; ISO:MGI.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; ISO:MGI.
DR InterPro; IPR019465; Cog5.
DR PANTHER; PTHR13228; PTHR13228; 1.
DR Pfam; PF10392; COG5; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..829
FT /note="Conserved oligomeric Golgi complex subunit 5"
FT /id="PRO_0000320146"
FT MOD_RES 166
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UP83"
FT CONFLICT 190
FT /note="G -> R (in Ref. 1; BAC27065)"
FT /evidence="ECO:0000305"
FT CONFLICT 430
FT /note="F -> Y (in Ref. 1; BAC27065)"
FT /evidence="ECO:0000305"
FT CONFLICT 655
FT /note="L -> M (in Ref. 1; BAC27065)"
FT /evidence="ECO:0000305"
FT CONFLICT 826
FT /note="S -> Y (in Ref. 1; BAC27065)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 829 AA; 91391 MW; E4041125F09250DD CRC64;
MEGGDSTISV AGRGASGSAV VAATVQAILQ DDCYSEFLNE DFDVKTYTSQ SIHQAVIAEQ
LAKLAQGISQ LDKELHLQVV ARHEDLLAQA TGIESLEGVL QMMQTRIGAL QGAVDRMKSK
IVEPYNKIVA RTAQLARLQV ACDLLRRIIR ILYLSKRLQG QLQGGSREIT KAAQSLNELD
YLSQGIDLSG IEVIENDLLF IARARLEVEN QAKRLLEQGV ETQNPTQVGT ALQVFHNLGT
LKETVTSVVD GYCAALEDSI NNALDVKVLT QPSQSAVRGG PGRAAMPTPG STAGFRASLW
TNMEKLMDHI CAACGQVQHL QKVLTKKRDP VSHICFIEEI IKDGQPEILY MFWNAVTLAL
SSHFHSATNS SMFLKQAFEG EYPKLLRLYN DLWKRLQQSS QNTQGTFSPS GTPDLCVDLP
HMEDDTQDMF RLKRPDYDPE KALKDSLQPY EAAYLSKSLS RLFDPINLVF PPGGRNPPSS
DELDGITKTI TSELNVAAVD ANLTLAVSKN VAKTIQLYAV KSEQLLSTQG DASQVIGPLT
EGQKRNVGVV NSLFKLHQSV TKVVASQSSF SATAEQTIMS ALKTIHDLMG NAIQPLLTSV
ADAIEAIIIT MHQEDFSGAS SSSGKPDVPC SLYMKELQGF IARVMNDYFK HFECLDFVFD
NTEAIAQRAI ELFIRNASLI RPLGEGGKLR LAADFAQMEL AVGPLCRRVS DLGKSYRMLR
SFRPLLFQTS EHVADSPAVG DIIPFSIIIQ FLFTRAPAEL KSPFQRAEWS HARFSQWLDD
HPSEKDRLLL LRGALEAYVQ SVRSRDGKEF APVYPIMVQL LQKAMSALQ
