COG5_YEAST
ID COG5_YEAST Reviewed; 403 AA.
AC P53951; D6W1C8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 5;
DE Short=COG complex subunit 5;
DE AltName: Full=Complexed with DOR1 protein 4;
DE AltName: Full=Component of oligomeric Golgi complex 5;
GN Name=COG5; Synonyms=COD4; OrderedLocusNames=YNL051W;
GN ORFNames=N2476, YNL2476W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=S288c / FY1676;
RX PubMed=8533472; DOI=10.1002/yea.320111008;
RA Bergez P., Doignon F., Crouzet M.;
RT "The sequence of a 44 420 bp fragment located on the left arm of chromosome
RT XIV from Saccharomyces cerevisiae.";
RL Yeast 11:967-974(1995).
RN [2]
RP ERRATUM OF PUBMED:8533472.
RX PubMed=8904343;
RX DOI=10.1002/(sici)1097-0061(19960315)12:3<297::aid-yea940>3.0.co;2-d;
RA Bergez P., Doignon F., Crouzet M.;
RL Yeast 12:297-297(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP SUBUNIT.
RX PubMed=11703943; DOI=10.1016/s1534-5807(01)00063-6;
RA Whyte J.R., Munro S.;
RT "The Sec34/35 Golgi transport complex is related to the exocyst, defining a
RT family of complexes involved in multiple steps of membrane traffic.";
RL Dev. Cell 1:527-537(2001).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP COMPOSITION OF THE COG COMPLEX, AND INTERACTION WITH COG4.
RX PubMed=15047703; DOI=10.1074/jbc.m400662200;
RA Loh E., Hong W.;
RT "The binary interacting network of the conserved oligomeric Golgi tethering
RT complex.";
RL J. Biol. Chem. 279:24640-24648(2004).
CC -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC is involved in intra-Golgi protein trafficking. COG is located at the
CC cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC and possibly a number of other membrane trafficking events.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi (COG or
CC Sec34/Sec35) complex which consists of eight different proteins COG1-
CC COG8. {ECO:0000269|PubMed:11703943}.
CC -!- INTERACTION:
CC P53951; P53079: COG1; NbExp=6; IntAct=EBI-4841, EBI-4835;
CC P53951; P53271: COG2; NbExp=3; IntAct=EBI-4841, EBI-16614;
CC P53951; P40094: COG3; NbExp=3; IntAct=EBI-4841, EBI-16605;
CC P53951; Q06096: COG4; NbExp=4; IntAct=EBI-4841, EBI-4823;
CC P53951; P53951: COG5; NbExp=2; IntAct=EBI-4841, EBI-4841;
CC P53951; P53959: COG6; NbExp=2; IntAct=EBI-4841, EBI-4829;
CC P53951; P53195: COG7; NbExp=6; IntAct=EBI-4841, EBI-4847;
CC P53951; Q04632: COG8; NbExp=3; IntAct=EBI-4841, EBI-6035;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: Present with 468 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the COG5 family. {ECO:0000305}.
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DR EMBL; U12141; AAA99661.1; -; Genomic_DNA.
DR EMBL; Z71327; CAA95920.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10494.1; -; Genomic_DNA.
DR PIR; S62979; S62979.
DR RefSeq; NP_014347.1; NM_001182890.1.
DR AlphaFoldDB; P53951; -.
DR SMR; P53951; -.
DR BioGRID; 35773; 556.
DR ComplexPortal; CPX-1840; COG Golgi transport complex.
DR DIP; DIP-5711N; -.
DR IntAct; P53951; 10.
DR MINT; P53951; -.
DR STRING; 4932.YNL051W; -.
DR MaxQB; P53951; -.
DR PaxDb; P53951; -.
DR PRIDE; P53951; -.
DR EnsemblFungi; YNL051W_mRNA; YNL051W; YNL051W.
DR GeneID; 855676; -.
DR KEGG; sce:YNL051W; -.
DR SGD; S000004996; COG5.
DR VEuPathDB; FungiDB:YNL051W; -.
DR eggNOG; ENOG502QQP3; Eukaryota.
DR GeneTree; ENSGT00390000004586; -.
DR HOGENOM; CLU_060138_0_0_1; -.
DR InParanoid; P53951; -.
DR OMA; YFWRTLA; -.
DR BioCyc; YEAST:G3O-33084-MON; -.
DR PRO; PR:P53951; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P53951; protein.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0000139; C:Golgi membrane; IC:ComplexPortal.
DR GO; GO:0017119; C:Golgi transport complex; IMP:SGD.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0032258; P:cytoplasm to vacuole transport by the Cvt pathway; IMP:SGD.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IMP:SGD.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; IC:ComplexPortal.
DR InterPro; IPR019465; Cog5.
DR PANTHER; PTHR13228; PTHR13228; 1.
DR Pfam; PF10392; COG5; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..403
FT /note="Conserved oligomeric Golgi complex subunit 5"
FT /id="PRO_0000213512"
SQ SEQUENCE 403 AA; 45604 MW; 619D6FF3B4A76A52 CRC64;
MTIAPMANDL EDFESLLEPD FDAKQFGNDL LKATNNNDTT ILDLNTPLKK LNYDLHEIDS
RIDQLMNSNP LEIIELIYKN EHVNSTIVGE LKPSLGYMNM SYDRLKNQVL DPYERARKVQ
LALSKVYQTS FLLRGALLYI HLSNKLNALS KTAQLSTSTA INLASLHYQL EITLEENKNL
KSLRKIKQLD QDIVSPNKRE LITFLSLQMC KECLNSIKIK SNKEIISQLA YSLYLLSSQE
FESAINKIVL SNVTMSSQIL SKILNSIRMF PDAFNEVVEK GYNIYILETL LQNIKTDNVT
NSSRSIAANK SRLGNLLSEY TSMKSKAGSG TPRDLFWSKV SSAFKKDFDI SVNRGGPVGK
SLLKNKDFII NTMKQSMKKS SDNSDYQSYL DVMLNSVSIS LNK
