ID   COG6_AJECN              Reviewed;         645 AA.
AC   A6R6L9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=COG6; ORFNames=HCAG_05277;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; CH476659; EDN08778.1; -; Genomic_DNA.
DR   RefSeq; XP_001539810.1; XM_001539760.1.
DR   AlphaFoldDB; A6R6L9; -.
DR   SMR; A6R6L9; -.
DR   STRING; 339724.A6R6L9; -.
DR   EnsemblFungi; EDN08778; EDN08778; HCAG_05277.
DR   GeneID; 5445914; -.
DR   KEGG; aje:HCAG_05277; -.
DR   VEuPathDB; FungiDB:HCAG_05277; -.
DR   HOGENOM; CLU_011361_1_0_1; -.
DR   OMA; RFYQQIM; -.
DR   OrthoDB; 1370285at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IEA:InterPro.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..645
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000339310"
SQ   SEQUENCE   645 AA;  71419 MW;  9A004B6E2F429529 CRC64;
     MARSCKILAK LPRVGTAISN LTNVCEEMRR HIVLATQETA PLFEEAAILM SQQQEVETKE
     KILDAFNNHF ILSEDELSSL TSSAKPVDDL FFDALARMKQ IHKDCEVLLG SENQRLGLDI
     MEQSSKNLNG AFQKLYKWIQ KEFKSLNLED PQISLSIRRA LRVLAERPSL FHNCLDSFAD
     AREYTLSDSF HTALTDVPSG QERDMAARPI EFSAHDPLRY VGDMLAWVHS AAVSEREALE
     ALFIGDEGEI AKGIQAGVNN EPWSRVDGEE IVFDGPKALN DLVTRDLNGV TRSLRQRVEL
     VLQGNEDSIV IYKIIGLLAF YENTFSKLLG RESGLVTSVA SLQEFAFKHF QILMQDQLAV
     VSAEPANLTP PADLSTPQFL HDALDNLTSL MKAYDSSFAH EHANDSSGEN KFSPIIREAL
     DPFLELAKTS SNDISDPTSR AVFHVNCLLS TRDAISPYPF VCVTHLPQLT NTLKTLRTTL
     LEIQHEFLLN ASGLHILLTA LKPFTPPATA TLEPTRSSYP PDLATISSLP EFQPQTLSSI
     SQQLDDFLPS ALVDVTENLK AIHSPVLVKS VTEEAVEAFC TDFEFVEGMI LGADEARGKL
     VVHGDGEDVG AEEAGEGEGE EPQADNWRLR SLFPRTTGEI RVLLS