COG6_ARATH
ID COG6_ARATH Reviewed; 680 AA.
AC Q6NMI3; Q9C6R8;
DT 13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 6 {ECO:0000303|PubMed:27448097};
DE Short=COG complex subunit 6 {ECO:0000303|PubMed:27448097};
DE AltName: Full=Component of oligomeric Golgi complex 6 {ECO:0000303|PubMed:27448097};
GN Name=COG6 {ECO:0000303|PubMed:27448097};
GN OrderedLocusNames=At1g31780 {ECO:0000312|Araport:AT1G31780};
GN ORFNames=F5M6.21 {ECO:0000312|EMBL:AAG50721.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
RN [6]
RP INTERACTION WITH COG5; COG7 AND COG8, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=27448097; DOI=10.1371/journal.pgen.1006140;
RA Tan X., Cao K., Liu F., Li Y., Li P., Gao C., Ding Y., Lan Z., Shi Z.,
RA Rui Q., Feng Y., Liu Y., Zhao Y., Wu C., Zhang Q., Li Y., Jiang L., Bao Y.;
RT "Arabidopsis COG complex subunits COG3 and COG8 modulate golgi morphology,
RT vesicle trafficking homeostasis and are essential for pollen tube growth.";
RL PLoS Genet. 12:E1006140-E1006140(2016).
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000250|UniProtKB:P53959}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization (Probable). Interacts with COG5, COG7 and
CC COG8 (PubMed:27448097). {ECO:0000269|PubMed:27448097,
CC ECO:0000305|PubMed:27448097}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305};
CC Peripheral membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG50721.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC079041; AAG50721.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31392.1; -; Genomic_DNA.
DR EMBL; BT011677; AAS49040.1; -; mRNA.
DR EMBL; AK226330; BAE98481.1; -; mRNA.
DR PIR; D86441; D86441.
DR RefSeq; NP_174458.2; NM_102912.5.
DR AlphaFoldDB; Q6NMI3; -.
DR SMR; Q6NMI3; -.
DR IntAct; Q6NMI3; 7.
DR STRING; 3702.AT1G31780.1; -.
DR iPTMnet; Q6NMI3; -.
DR PaxDb; Q6NMI3; -.
DR PRIDE; Q6NMI3; -.
DR ProteomicsDB; 179360; -.
DR EnsemblPlants; AT1G31780.1; AT1G31780.1; AT1G31780.
DR GeneID; 840065; -.
DR Gramene; AT1G31780.1; AT1G31780.1; AT1G31780.
DR KEGG; ath:AT1G31780; -.
DR Araport; AT1G31780; -.
DR TAIR; locus:2034506; AT1G31780.
DR eggNOG; KOG3758; Eukaryota.
DR HOGENOM; CLU_011361_3_0_1; -.
DR InParanoid; Q6NMI3; -.
DR OMA; RFYQQIM; -.
DR OrthoDB; 1370285at2759; -.
DR PhylomeDB; Q6NMI3; -.
DR PRO; PR:Q6NMI3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6NMI3; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IDA:TAIR.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IMP:TAIR.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0009860; P:pollen tube growth; IMP:TAIR.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010490; COG6.
DR PANTHER; PTHR21506; PTHR21506; 1.
DR Pfam; PF06419; COG6; 1.
DR SMART; SM01087; COG6; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..680
FT /note="Conserved oligomeric Golgi complex subunit 6"
FT /id="PRO_0000448528"
FT REGION 479..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 680 AA; 75792 MW; 2F46503CC78CACB3 CRC64;
MASTVGLAPG LSRKLKKVLD CRTDSPDLVA SLNALSSFYD ENSAHARRNL RSTIEKRALQ
INSEFLNAAD STQIALDRVE EEVNALADCC DKIAAALSSS AATTSDIIST TERLKQELEV
TTQRQEIVNC FLRDYQLSNE EIKALREDEL NENFFQALSH VQEIHSNCKL LLRTHHQRAG
LELMDMMAVY QEGAYERLCR WVQAECRKLG DTDNPEVSEL LRTAVRCLKE RPVLFKYCAE
EVGNLRHNAL FRRFISALTR GGPGGMPRPI EVHAHDPLRY VGDMLGWLHQ ALASERELVH
ALFDIDSADH QSNAKNTSEN IALKAGESDF TFVLDRIFEG VCRPFKVRVE QVLQSQPSLI
ISYKLTNTLE FYSYTISDLL GRDTALCNTI GMVKDAAQKT FFDILKTRGE KLLRYPPPVA
VDLSPPPAVR EGVSLTLEII ENYNSMMVSA SGEKPAFDPV LSALLDPIIK MCEQAAEAHK
SKKSGQLPRR SRTSSDSSQL TSVDALLSSS PSPPQNNETP SKIFLINCLC AIQQPLLRHD
VASQYVTNIG LMIENHINLL VQNEVDTLLH KCGLSDKMQI FRSSTSELPL SERQDTSPAM
LSECLKAFFG LVLGSEGSLP EFEQIQVPKL RSEACVRVAK TLAEAYEVIY QAVTDQQNGY
PDPKSLARHP PDQIRTILGI
