ID   COG6_ASHGO              Reviewed;         806 AA.
AC   Q75AZ8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=COG6; OrderedLocusNames=ADL228C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 329; 336; 339 AND 355-377.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS51692.2; -; Genomic_DNA.
DR   RefSeq; NP_983868.2; NM_209221.2.
DR   AlphaFoldDB; Q75AZ8; -.
DR   STRING; 33169.AAS51692; -.
DR   EnsemblFungi; AAS51692; AAS51692; AGOS_ADL228C.
DR   GeneID; 4620003; -.
DR   KEGG; ago:AGOS_ADL228C; -.
DR   eggNOG; KOG3758; Eukaryota.
DR   HOGENOM; CLU_017837_0_0_1; -.
DR   InParanoid; Q75AZ8; -.
DR   OMA; IINMICP; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR   GO; GO:0032258; P:cytoplasm to vacuole transport by the Cvt pathway; IEA:EnsemblFungi.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..806
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000339311"
SQ   SEQUENCE   806 AA;  92536 MW;  7B60D303FF307711 CRC64;
     MDFLDYQAYG VPLTGTDDEL LPEPASNLSL LAASGPSVSE LNTSIQGDST PPLLNTDSNF
     NFEGKDNLHE RMEMYSELTV KLLPIQPGLV RDIFEDVTPQ SSDFQHLLKK GNNVTSAVLV
     KRLSHVLNDM NHPNYQSDLQ LKKALMILQD NQGVLGLDGS KLVRPDFLGS LSRKTLRSQL
     EKELLKDHLA TLENFQPIAR RIMRLRQPVK NIQEISEKVL DAQEAQNKSP LQDPLVSEVR
     EKLEMLKLKK RVLVGIRESL TLNQLEDEQL RNGEIEDSYL DVLDKMMEIK ERSTYLIAMN
     YEKAGKALLG NINQYLQLAN KRIYNYLLGF LYDYESNTKT FGERNFEGDN VGLSLFQRCL
     VYLSNDLEYF NDFMKKVTSM RSKKLLDEFL IPFVIDNNEG RSIILSAHDP ARYLGDVLAH
     VHSLLANEGD FLKSLFKYQE ERMADMTQSI FQKNKDILQS LHVNMLNDIM STLSNSVRIR
     LEQIVRFEEE ATVTFDISQL LSLYKLMFTK QGMLDDNKLV KVFDDLAVLA KTKTMNYYTE
     FLSEAVKEEP EVTDLLPPKW LSKYLSDLTA LFDKINGSSE QTGIVDKNFF TKLVKTPCES
     TFLKQAELCF PLAKKDRRVK FDLLVLEING LDMIVSRLGP YRTNIFSDEY GSEVYDSLKR
     SLDTLLGQLE VHQTRNILES TGLELYYNLF NMIFPVASVQ DPLDYDMYLS AQENQIMKLE
     TIETNIAQKL SDYLPKALLD VQDTWLLYLA SPKFADDIAS RSFHVFANFY VVFKSVLLNI
     FPDDHQRINS IFIYSEEEVK MLLGIN