ID   COG6_ASPCL              Reviewed;         755 AA.
AC   A1CU89;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=cog6; ORFNames=ACLA_085730;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; DS027060; EAW06876.1; -; Genomic_DNA.
DR   RefSeq; XP_001268302.1; XM_001268301.1.
DR   AlphaFoldDB; A1CU89; -.
DR   STRING; 5057.CADACLAP00007667; -.
DR   EnsemblFungi; EAW06876; EAW06876; ACLA_085730.
DR   GeneID; 4700494; -.
DR   KEGG; act:ACLA_085730; -.
DR   VEuPathDB; FungiDB:ACLA_085730; -.
DR   eggNOG; KOG3758; Eukaryota.
DR   HOGENOM; CLU_011361_1_0_1; -.
DR   OMA; RFYQQIM; -.
DR   OrthoDB; 1370285at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IEA:InterPro.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..755
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000339312"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          600..630
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   755 AA;  83620 MW;  483C48B170548BE0 CRC64;
     MASYFPHGAT NSHASMRSPS PAASPLSPPP QRSNALSNRL TSVLSASYAD SDIRDALETL
     SLRGIHNTAE TRRQLRLDVQ KEVVDSNAEI VRDFGTVAEQ LQRIGAVISS LNQTCEEMRQ
     HIFLAKQDTT PVLEEASALV SQKQESETKQ QLLDAFAKHF IIPEEELPVL TSLEEPIDDH
     FFNVLARVKQ VHHDCEVLLE GENQRLGLEL MEKSSRTLNS AYQKLFRWIQ KEFQSLNLED
     PRISSSIRRA LRVLAERPSL FHSCLDFFAE ARDYALSDAF HYALTDAVSG TGGDRSVKPI
     EFSAHDPLRY VGDMLAWVHS STVSEREALE ALFVADGDEI AKGIQAGLSS EPWSRIDEEE
     EVSFDGQKAL SDLVNRDLIG VSRSLRQRVE LVIQGHDDPV SCYKIVHLFL FYRATFSKLL
     GPQSNLTELM ETLEKFAFTR FERIMREQVT VLSSDHSALT PPEDLSAPEF FLDALEALTS
     LMKTHDASLG TEDADRAPAA ENQFTPVLRA AFDPYLELAR SSATELQDAT ARAMYTTNIL
     LTARSTISAF PFASATHLPP ISTALSDLRT DLLGIQHRYL LDASGLGLLL TALEPFSPST
     TTTITTTKPK PDTNPEDTDT DTTLPTKKPP PNIAAIATLP AFQPDALIAT SQQLDDFLPS
     ALMDATENLK RLQSATFVKS VTEEAVEAFC RDFEFVEGMI IGADEAAGRV DIARVDGDGD
     NEAEIHEGEE LKLEQEMGLR RLFPRTTGEI RVLLS