ACPH_ECOLI
ID ACPH_ECOLI Reviewed; 193 AA.
AC P21515; P46123; P77369; Q2MC22;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Acyl carrier protein phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_01950};
DE Short=ACP phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_01950};
DE EC=3.1.4.14 {ECO:0000255|HAMAP-Rule:MF_01950};
GN Name=acpH {ECO:0000255|HAMAP-Rule:MF_01950}; Synonyms=yajB;
GN OrderedLocusNames=b0404, JW0394;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=1706703; DOI=10.1128/jb.173.7.2256-2264.1991;
RA Reuter K., Slany R., Ullrich F., Kersten H.;
RT "Structure and organization of Escherichia coli genes involved in
RT biosynthesis of the deazaguanine derivative queuine, a nutrient factor for
RT eukaryotes.";
RL J. Bacteriol. 173:2256-2264(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP FUNCTION, AND CATALYTIC ACTIVITY.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=16107329; DOI=10.1074/jbc.m505736200;
RA Thomas J., Cronan J.E.;
RT "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli:
RT genetic and enzymological characterization.";
RL J. Biol. Chem. 280:34675-34683(2005).
CC -!- FUNCTION: Converts holo-ACP to apo-ACP by hydrolytic cleavage of the
CC phosphopantetheine prosthetic group from ACP. {ECO:0000255|HAMAP-
CC Rule:MF_01950, ECO:0000269|PubMed:16107329}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + holo-[ACP] = (R)-4'-phosphopantetheine + apo-[ACP] +
CC H(+); Xref=Rhea:RHEA:20537, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:9690,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
CC ChEBI:CHEBI:61723, ChEBI:CHEBI:64479; EC=3.1.4.14;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01950,
CC ECO:0000269|PubMed:16107329};
CC -!- SIMILARITY: Belongs to the AcpH family. {ECO:0000255|HAMAP-
CC Rule:MF_01950}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA16113.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M37702; AAA16113.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U82664; AAB40160.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73507.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE76184.1; -; Genomic_DNA.
DR PIR; D64769; D64769.
DR RefSeq; NP_414938.1; NC_000913.3.
DR RefSeq; WP_001009885.1; NZ_SSZK01000009.1.
DR AlphaFoldDB; P21515; -.
DR SMR; P21515; -.
DR BioGRID; 4261717; 13.
DR IntAct; P21515; 2.
DR STRING; 511145.b0404; -.
DR jPOST; P21515; -.
DR PaxDb; P21515; -.
DR PRIDE; P21515; -.
DR EnsemblBacteria; AAC73507; AAC73507; b0404.
DR EnsemblBacteria; BAE76184; BAE76184; BAE76184.
DR GeneID; 949132; -.
DR KEGG; ecj:JW0394; -.
DR KEGG; eco:b0404; -.
DR PATRIC; fig|511145.12.peg.420; -.
DR EchoBASE; EB1087; -.
DR eggNOG; COG3124; Bacteria.
DR HOGENOM; CLU_099370_1_0_6; -.
DR InParanoid; P21515; -.
DR OMA; MNFLAHI; -.
DR PhylomeDB; P21515; -.
DR BioCyc; EcoCyc:EG11095-MON; -.
DR BioCyc; MetaCyc:EG11095-MON; -.
DR BRENDA; 3.1.4.14; 2026.
DR PRO; PR:P21515; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0008770; F:[acyl-carrier-protein] phosphodiesterase activity; IDA:EcoCyc.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IDA:EcoCyc.
DR HAMAP; MF_01950; AcpH; 1.
DR InterPro; IPR007431; ACP_PD.
DR InterPro; IPR023491; ACP_phosphodiesterase_gpbac.
DR PANTHER; PTHR38764; PTHR38764; 1.
DR Pfam; PF04336; ACP_PD; 1.
DR PIRSF; PIRSF011489; DUF479; 1.
PE 1: Evidence at protein level;
KW Fatty acid biosynthesis; Fatty acid metabolism; Hydrolase;
KW Lipid biosynthesis; Lipid metabolism; Reference proteome.
FT CHAIN 1..193
FT /note="Acyl carrier protein phosphodiesterase"
FT /id="PRO_0000168605"
SQ SEQUENCE 193 AA; 22961 MW; 0DE6F0CE01D6C523 CRC64;
MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV LTDNLPEVRE
AREWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE FVCYAREQVM TILPDSPPRF
INLNNYLWSE QWLVRYRDMD FIQNVLNGMA SRRPRLDALR DSWYDLDAHY DALETRFWQF
YPRMMAQASR KAL
