ID   COG6_CANAL              Reviewed;         771 AA.
AC   Q59MF9; A0A1D8PHJ6;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=COG6; OrderedLocusNames=CAALFM_C205850CA;
GN   ORFNames=CaO19.12676, CaO19.5209;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27596.1; -; Genomic_DNA.
DR   RefSeq; XP_710917.2; XM_705825.2.
DR   AlphaFoldDB; Q59MF9; -.
DR   SMR; Q59MF9; -.
DR   STRING; 237561.Q59MF9; -.
DR   PRIDE; Q59MF9; -.
DR   GeneID; 3647472; -.
DR   KEGG; cal:CAALFM_C205850CA; -.
DR   CGD; CAL0000198191; orf19.12676.
DR   VEuPathDB; FungiDB:C2_05850C_A; -.
DR   eggNOG; KOG3758; Eukaryota.
DR   HOGENOM; CLU_017837_0_0_1; -.
DR   InParanoid; Q59MF9; -.
DR   OrthoDB; 1370285at2759; -.
DR   PRO; PR:Q59MF9; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..771
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000339317"
SQ   SEQUENCE   771 AA;  88464 MW;  F288EC3D7C02DBB5 CRC64;
     MDFIDFDTFT KDASGSDNDV FPQPQPPLSL PIASNLDQFS KKLSNLVLPG NILNNDNTKP
     SNEISEVDNV MEKYAKMSID LIKRETGDVQ LENEEDSKES SVRTSLSTRL SRVLNDSLSD
     ATIREIFSNL QERFDKESNG YVVDLIESGI VGSMSRKKFK GRIESELIRN QSNILKQYQP
     IVKQLKQIEV KLNKLNELSV QTNDKINKNF DFSNKLNLEI KDLNDNKRLI GLKKNLLISF
     KEKFTLNEYE EFVLNSGDLN NEFFTTLARA ERINENCSIL LSLDNPQLGL KIIAKSNQMI
     NRSIDRIVSY TNKTLGNMYS LSSKSRLATL HQCFKYLQNK LNYFNSIVNT FSESRSKVLV
     DEFNRQVQGD FEVNGQGRSS SISSDSRPIY MSAHDPVRFV GDLLAYVHSV SVNESETITS
     IFTMGDDNDK EFENIIQDVT DKILQSLSRP IKARVEQIVS TETKLSTLVQ IFNLVELYNI
     MFTKQLGKAG NIVETVKQLI KVCQGRIFMI ISNRLATIKN KNSTKLDLNL DLQPPEWIIE
     FYSDILPIVD QITTETILNL SPEENEKFLN LIVNEPIQVF NEHVDHNKVF SEKKDVLIIK
     SNFLDLILSK TIPVSLLSEK VLEVNEMIDK LTEEITQLEL NNMLGQCGLY DYFNIINMIC
     PFSDDFFEVS IYEPIKENKL YTKDSFVQVD EKVQEFFPSA MIEMQQSLLK LNSPIVVNQI
     IDNSFMQFVK FYCKLDLINK EYLDFSFTWS DMEIATLVGI EDVYSKDISI M