ID   COG6_COCIM              Reviewed;         732 AA.
AC   Q1E6R9; J3KK70;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=COG6; ORFNames=CIMG_01744;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; GG704911; EAS36390.3; -; Genomic_DNA.
DR   RefSeq; XP_001247973.2; XM_001247972.2.
DR   AlphaFoldDB; Q1E6R9; -.
DR   SMR; Q1E6R9; -.
DR   STRING; 246410.Q1E6R9; -.
DR   EnsemblFungi; EAS36390; EAS36390; CIMG_01744.
DR   GeneID; 4566865; -.
DR   KEGG; cim:CIMG_01744; -.
DR   VEuPathDB; FungiDB:CIMG_01744; -.
DR   InParanoid; Q1E6R9; -.
DR   OMA; RFYQQIM; -.
DR   OrthoDB; 1370285at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IEA:InterPro.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..732
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000339320"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   732 AA;  80554 MW;  BE7DA742240A9A33 CRC64;
     MAAGSPSPDG MPSSPHMANT GSTPKPTALF NRLNAVLSTS YTDPDIRDSL ETLDKRGLQN
     TAETRRTLRL DIQKEVIDSN GSIIQDFGKV AEQLSRIGAA ISHLNTICED MRQHITSARQ
     ETEPVLEEAA ALLSQKQEVE TKQHLLDAFN KHFVLSSDDI SILTSTAEPV DDRFFQILSR
     QKRIHKDCEV LLGGENQRLG LEIMEQSSKN LNSAFMKLYK WIQKEFKSSN LEDPQMGSSI
     RKGLRVLAER PTLFHSCLDF FAEAREYILS DSFHYALTAA VSGDRLDANA KPIEFSAHDP
     LRYVGDMLAW VHSATVSERE ALEALFISDG GELVKGIEAG ISSEPWSRIN DEQSVFDGEK
     ALKELVTRDM SGVARSLKQR VELAVQGHDE LVTLYKIMNL LAFYESTFSK LVGHDSALVE
     AITSLQDFVF KRLEAVIHDQ IATITGDPSG LIPPDDLSAP EFLTDAIDNL VPLMKAYDSS
     FRHDITDDTS QNENKFSPII RATLDPFLDL AEKSSTALSN FTSRTIYQTN SILVIRDAIS
     PFPFACATHL PRLSSTLTSL KTNLLDIQHD FLLRETGLQT LTAALEPFMP KSTSESSTGN
     GLSRNLADIA SLPEFQPESL STISQQLDDF LPSALVDATD NLKRIHSPGL VKNATEEAVE
     AFCCDFELVE SMIVGADEAR EKMSVAGTVS SSAAGKEMDE IAALGETSGQ VGAWSLRVLF
     PRTTGEIRVL LS