ID   COG6_CRYNB              Reviewed;         742 AA.
AC   P0CM81; Q55JD7; Q5KCC2;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=COG6; OrderedLocusNames=CNBL0500;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; AAEY01000055; EAL17923.1; -; Genomic_DNA.
DR   RefSeq; XP_772570.1; XM_767477.1.
DR   AlphaFoldDB; P0CM81; -.
DR   SMR; P0CM81; -.
DR   PRIDE; P0CM81; -.
DR   EnsemblFungi; EAL17923; EAL17923; CNBL0500.
DR   GeneID; 4939094; -.
DR   KEGG; cnb:CNBL0500; -.
DR   VEuPathDB; FungiDB:CNBL0500; -.
DR   HOGENOM; CLU_011361_2_0_1; -.
DR   Proteomes; UP000001435; Chromosome 12.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IEA:InterPro.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Transport.
FT   CHAIN           1..742
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000410043"
FT   REGION          692..742
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        702..742
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   742 AA;  83679 MW;  33586B92B957C5B9 CRC64;
     MSTNPNTPAP PASRTNPISL RIYKAIGTSF DDVSSREALE IASGMYGPED PKAKGKAQPE
     YEELEEDDDT LPKRRTLKGQ SAAIARKYLK QDIETCLATG STKFLEAFAE VDQKLNVLRE
     HMQEMQVRCD QVQSELDQAN SGTKFLLERA DVLRSQRDSA QLRAHLITLF LSRFTLSNSE
     LTALTSREVT IGQPLFDALD HVEKIRTDCE VLLSGEEGKA QAGLDIMSLT SEQLESGYSK
     IHRYCQFEFR QFTREAQLEA SSVMRQAICR LRDRPALLAD AIQTLTSTRQ SSILHQFLDA
     LTRGGPGGLP RPIEIHAHDP TRYVGDMLAW VHQTTATEHE FLEGMFGVKE KKRWVGQERG
     GEEGEEERMA SEVLDKDLEG LSRPLKLRIQ ETIKSQEGII MTYKIANLLH FYLVTMRKTI
     GGKAMLVQTL QEIHDQAYIA FYETLDAQGR GLLRFLHPPD ATLTPPITLR DAAQILRELL
     FVYSTSLIDP AERESDADLA KLLDKAVGPC VEMCERMAEM RRGKSGGGEW ERDIFMVNSL
     GYLEHTLEMY DFTTKTLHML DEKIKTHVES MTFEHHGKLL ESCGLAAVMR TIRTRPEDTP
     LSRLHATSPK SLTSALSKFS TWISTVDPST SPRLALLTSP RLAVEIHRKA LRKIYDAYGE
     ICERVLDKAE GYEFGETMLR RGRDEVGVAL GVGEDWELEE DTEEKSMKQK EQQDEDTEDQ
     GEKGIMQEEH KAQDAGNTED KA