COG6_DROME
ID COG6_DROME Reviewed; 630 AA.
AC Q9V564; Q95RW7;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE Short=COG complex subunit 6;
DE AltName: Full=Component of oligomeric Golgi complex 6 {ECO:0000312|FlyBase:FBgn0033401};
GN Name=Cog6 {ECO:0000312|FlyBase:FBgn0033401};
GN ORFNames=CG1968 {ECO:0000312|FlyBase:FBgn0033401};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Required for normal Golgi function. {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=Q9V564-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=Q9V564-2; Sequence=VSP_001133, VSP_001134;
CC -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF58956.1; -; Genomic_DNA.
DR EMBL; AE013599; AAM68826.1; -; Genomic_DNA.
DR EMBL; AY061082; AAL28630.1; -; mRNA.
DR RefSeq; NP_610476.1; NM_136632.5. [Q9V564-2]
DR RefSeq; NP_724783.1; NM_165673.3. [Q9V564-1]
DR AlphaFoldDB; Q9V564; -.
DR SMR; Q9V564; -.
DR BioGRID; 61789; 30.
DR DIP; DIP-17959N; -.
DR IntAct; Q9V564; 1.
DR STRING; 7227.FBpp0087676; -.
DR PaxDb; Q9V564; -.
DR PRIDE; Q9V564; -.
DR DNASU; 35953; -.
DR EnsemblMetazoa; FBtr0088595; FBpp0087676; FBgn0033401. [Q9V564-1]
DR EnsemblMetazoa; FBtr0088596; FBpp0087677; FBgn0033401. [Q9V564-2]
DR GeneID; 35953; -.
DR KEGG; dme:Dmel_CG1968; -.
DR UCSC; CG1968-RA; d. melanogaster. [Q9V564-1]
DR CTD; 57511; -.
DR FlyBase; FBgn0033401; Cog6.
DR VEuPathDB; VectorBase:FBgn0033401; -.
DR eggNOG; KOG3758; Eukaryota.
DR GeneTree; ENSGT00390000013518; -.
DR HOGENOM; CLU_011361_3_0_1; -.
DR InParanoid; Q9V564; -.
DR OMA; RFYQQIM; -.
DR PhylomeDB; Q9V564; -.
DR Reactome; R-DME-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DME-6811438; Intra-Golgi traffic.
DR BioGRID-ORCS; 35953; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35953; -.
DR PRO; PR:Q9V564; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0033401; Expressed in embryonic/larval hemocyte (Drosophila) and 36 other tissues.
DR Genevisible; Q9V564; DM.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IDA:FlyBase.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:FlyBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR010490; COG6.
DR PANTHER; PTHR21506; PTHR21506; 1.
DR Pfam; PF06419; COG6; 1.
DR SMART; SM01087; COG6; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..630
FT /note="Conserved oligomeric Golgi complex subunit 6"
FT /id="PRO_0000213516"
FT VAR_SEQ 315..333
FT /note="DISDQLQNALGYIADGVCH -> GKIRKCIHYGTKIVLFVLQ (in
FT isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_001133"
FT VAR_SEQ 334..630
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000305"
FT /id="VSP_001134"
SQ SEQUENCE 630 AA; 71206 MW; 934113C7B266ABFD CRC64;
MSSTQEKPEE LDRIQKRVNK ILEARLESDK DTLDALSGLS TFFTENTLQN RRNLRSQIEH
RSVGINENFL KAFRQVKLSL DAVCEDLDTM ATSVETMKSD LETSKALTKD LIKQTNTMQR
ERDRLEVHKQ IAQAFLARFQ LSGAEHQLLY GAAKDAPIVA DFFRVLDRVQ SIHADCRLLM
QCGYQTAAID IMEEMTLHQE GALERLYRWT QNHCRSLENN EIGPLIVEAM SRLQDRPVLF
KYVIDEYAIA RRAVLVRQFI EALTEGGPGG NPKPIELHAH DPKRYIGDMF AWLHQSIPTE
KENLSLLFKK CDKQDISDQL QNALGYIADG VCHPLKVRVE TILQAEKDTI VLFTISNLLR
FYQQIMRQVV QGGSLEECLV ELQKSSEQIY LGALAAQVRS VLQRPSGGSG LALEPPQRDL
VPPPSVARLL NMLKEILSVA TMVDGRQADI TKIVSCVIDP LLQSVQESAA HLPTVDMGVY
LLNCLHHMQS SLAVYEYMDE RVERLQAQSD AQLDTLTSEQ ASSLVANLNL GPIYAILQSN
QSKIETNLLK IFMSKMDAFL ELPDVLLLPQ VQLIMSSSHR AAVQKRSFNV IVAIYKQIYE
RVHDPANGFE QPEQLLHRTP EQVAHILTST
