ID   COG6_KLULA              Reviewed;         779 AA.
AC   Q6CLC8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=COG6; OrderedLocusNames=KLLA0F03993g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG97969.1; -; Genomic_DNA.
DR   RefSeq; XP_455261.1; XM_455261.1.
DR   AlphaFoldDB; Q6CLC8; -.
DR   SMR; Q6CLC8; -.
DR   DIP; DIP-62105N; -.
DR   STRING; 28985.XP_455261.1; -.
DR   EnsemblFungi; CAG97969; CAG97969; KLLA0_F03993g.
DR   GeneID; 2895700; -.
DR   KEGG; kla:KLLA0_F03993g; -.
DR   eggNOG; KOG3758; Eukaryota.
DR   HOGENOM; CLU_017837_0_0_1; -.
DR   InParanoid; Q6CLC8; -.
DR   OMA; IINMICP; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IEA:EnsemblFungi.
DR   GO; GO:0032258; P:cytoplasm to vacuole transport by the Cvt pathway; IEA:EnsemblFungi.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:EnsemblFungi.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..779
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000339323"
SQ   SEQUENCE   779 AA;  89168 MW;  E2708BC88BB980FB CRC64;
     MDFLDFPALV VDESAALPQP ASRLSLASLR LNDDEQEAKF VLPNVSKHDT EFTDLHSKMK
     HFASISLGEI RPASVSLSKE VAAPISNNIE KPTTTNQLLS KKINSLLNVP NYASYTSDSE
     TKRALQILDA NHSDLGLNFN QLVASDFVGT LNRKSLRSKL ENSMLNSHSD ILSNFQSIAR
     RIKRLSGPLE RINNAMQNFK DTTESIDFEF EHVKDRLDQL KARRQVIIKL RDSLTLTQLE
     LDHLQNGTIN DLFFQILNKI NFIKEKATYL LSNEKTTSAG VALLKTMNNN LTVSNKRIYN
     YLINFIEEYD TLSRQYGERT IGDESLSNFQ TSLIHLSNDV QFFQDFLNRI VGLRSKRLLD
     DFLSQFDIDN KKLQRPIILS AHDPVRYLGD VLAYVHSMIV NELEFLKSTF KLKSELVTSD
     SVLKDNMDFI GDLHLKLLNE IFTSLANTIR IRLEQIVRFE NNPMLNLDIV QCLSLYQMML
     VKNGINESSQ LMTSLNDLEN LARSKIVSSV TSYLKDLDKN QIAAADLLPP DWFVDYLSKL
     SQLLNKLEQQ NETRILTDDL YDKLILDPIN NNLVLNLQNW FPTAKKEKSA RIDLLIVQIN
     SFDLVKSKLG PFHSTIFSSD YGKSVFSKLE TQYTLCVTKL KETMNSYLFE STGMELYFNL
     FNMIFPIISV QDELDYDMYL SAVENPIMKL AVIHDNIHEK LNTYLPLAVS DFQDVKLFNL
     MPPAVEEDIV STCFGNFIKF YKVFKSVLNK IYPEDEEMIM STLNFTTNEV STLLGVEDK