COG6_MOUSE
ID COG6_MOUSE Reviewed; 657 AA.
AC Q8R3I3; Q8BSN7; Q8CHB1; Q9CTA8;
DT 30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE Short=COG complex subunit 6;
DE AltName: Full=Component of oligomeric Golgi complex 6;
GN Name=Cog6; Synonyms=Kiaa1134;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Embryo, and Forelimb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-657.
RC TISSUE=Brain;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: I.
RT The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-657.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for normal Golgi function. {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH25427.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK004100; BAB23168.1; -; mRNA.
DR EMBL; AK031149; BAC27280.1; -; mRNA.
DR EMBL; AK153320; BAE31900.1; -; mRNA.
DR EMBL; AB093286; BAC41470.1; -; mRNA.
DR EMBL; BC025427; AAH25427.1; ALT_INIT; mRNA.
DR CCDS; CCDS50905.1; -.
DR RefSeq; NP_080501.2; NM_026225.3.
DR AlphaFoldDB; Q8R3I3; -.
DR SMR; Q8R3I3; -.
DR BioGRID; 212263; 6.
DR STRING; 10090.ENSMUSP00000048603; -.
DR PhosphoSitePlus; Q8R3I3; -.
DR EPD; Q8R3I3; -.
DR MaxQB; Q8R3I3; -.
DR PaxDb; Q8R3I3; -.
DR PeptideAtlas; Q8R3I3; -.
DR PRIDE; Q8R3I3; -.
DR ProteomicsDB; 283489; -.
DR DNASU; 67542; -.
DR GeneID; 67542; -.
DR KEGG; mmu:67542; -.
DR CTD; 57511; -.
DR MGI; MGI:1914792; Cog6.
DR eggNOG; KOG3758; Eukaryota.
DR InParanoid; Q8R3I3; -.
DR OrthoDB; 1370285at2759; -.
DR PhylomeDB; Q8R3I3; -.
DR TreeFam; TF314527; -.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR Reactome; R-MMU-6811438; Intra-Golgi traffic.
DR Reactome; R-MMU-6811440; Retrograde transport at the Trans-Golgi-Network.
DR BioGRID-ORCS; 67542; 21 hits in 73 CRISPR screens.
DR ChiTaRS; Cog6; mouse.
DR PRO; PR:Q8R3I3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8R3I3; protein.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; ISO:MGI.
DR GO; GO:0070085; P:glycosylation; ISS:UniProtKB.
DR GO; GO:0007030; P:Golgi organization; ISO:MGI.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; ISO:MGI.
DR InterPro; IPR010490; COG6.
DR PANTHER; PTHR21506; PTHR21506; 1.
DR Pfam; PF06419; COG6; 1.
DR SMART; SM01087; COG6; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..657
FT /note="Conserved oligomeric Golgi complex subunit 6"
FT /id="PRO_0000213514"
FT CONFLICT 288
FT /note="G -> E (in Ref. 3; AAH25427)"
FT /evidence="ECO:0000305"
FT CONFLICT 461
FT /note="V -> I (in Ref. 1; BAE31900/BAC27280)"
FT /evidence="ECO:0000305"
FT CONFLICT 620
FT /note="I -> V (in Ref. 1; BAB23168/BAE31900/BAC27280)"
FT /evidence="ECO:0000305"
FT CONFLICT 643
FT /note="N -> S (in Ref. 1; BAB23168/BAE31900/BAC27280)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 657 AA; 73040 MW; D305C8E5F623122C CRC64;
MADASGEVAA VPASGAANGF SNGAGATPAQ PNNPLSRKLH KILETRLEND KEMLEALKAL
SAFFVENSLR TRRNLRGDIE RRSLAINEEF VNIFKDVKEE LESINEDVQA MSSCCQDMTS
RLQAAKEQTQ DLIVKTTKLQ AENQRLEIRA QVVDAFLAKF QLTSDEMSLL RGTRGGPVTE
DFFKALGRVK QIHNDVKVLL RTNQQTAGLE IMEQMALLQE TAYERLYRWA QSECRALTQE
SCDVSAVLSQ AMEALQDRPV LYKYTLDEFG TARRSTVVRG FIDALTRGGP GGTPRPIEMH
SHDPLRYVGD MLAWLHQATA SEKEHLEALL KHVTAQGVKE NIQEVVGHIT EGVCRPLKVR
IEQVILAEPG AVLLYKISNL LKFYHHTISG IVGNSAATLL TTIEEMHLLS KKIFFTSLSL
HANKLMDKVE LPPPDLGPSS ALSQTLTLLR DILASHDSSV VPLDARQADF VQVLSCALDP
LLQMCTVSAS NLGTADMATF MVNSLYMMKT TLALFEFTDR RLEMLQFQIE AHLDTLINEQ
ASYVLTRVGL SYIYNTIQQH RPDQGSLANM PNLDAVALKA AMAQFDRYLS APDHLLMPQL
NSLLSATVKE QIIKQSTELI CRAYAEVHAA VMNPDNAYKD PENILHRSPE QVKTLLS
