ID   COG6_NEOFI              Reviewed;         731 AA.
AC   A1DNX2;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=cog6; ORFNames=NFIA_058440;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; DS027698; EAW16493.1; -; Genomic_DNA.
DR   RefSeq; XP_001258390.1; XM_001258389.1.
DR   AlphaFoldDB; A1DNX2; -.
DR   SMR; A1DNX2; -.
DR   STRING; 36630.CADNFIAP00005180; -.
DR   EnsemblFungi; EAW16493; EAW16493; NFIA_058440.
DR   GeneID; 4584906; -.
DR   KEGG; nfi:NFIA_058440; -.
DR   VEuPathDB; FungiDB:NFIA_058440; -.
DR   eggNOG; KOG3758; Eukaryota.
DR   HOGENOM; CLU_011361_1_0_1; -.
DR   OMA; RFYQQIM; -.
DR   OrthoDB; 1370285at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IEA:InterPro.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..731
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000339325"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          578..599
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          686..714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   731 AA;  80644 MW;  CAED2C3E1050751C CRC64;
     MESYFPPGAT ANHSSIRTSS PASTPLSPPT QRSNALSNRL TSVLSASYAD SDIRDALETL
     SLRGVHNTAE TRRQLRLDVQ KEVVECNAEI VRDFGKVAEH IVRAKQDTAP VIEEASALMN
     QKKESETKQQ LLDAFVKHFV VSDDDLLVLT SAEEPIDDRF FDVLDRVKQV HHDCEVLLGG
     ENQRLGLELM EKSSRNLNSA YQKLFRWIQK EFKSLNLEDP RISSSIRRAL RVLAERPSLF
     HSCLDFFADA RDYALSDAFH YALTDAVSGS GGDRNVKPIE FSAHDPLRYV GDMLAWVHST
     TVSEREALEA LFVADGEEIA KGIQAGLSSE PWSRIDEGEE VSFDGQKALS DLVNRDLVGV
     SRALRQRVEL VIQGHDEPVT CYKVVHLLSF YRATFSRLLG TKSNLADMMQ TLENFTFARF
     ESIMREQVNV LSNDHAALTP PDDLSAPEFF LDALEELTSL MKTHDASLGA EDAESESTAD
     NKFTPVLRVA FDPFLQLAKS SAAELPDATA RAIYTTNVLL TARSTISAFP FASATHLNPI
     STALSSLRME LLEIQHRYLL DASGLGVLLA ALESFSPSPT TSKPESEGKD GHAPPQADRQ
     PTDIAEIADL PAFQQEALIA VSQQLDDFLP SALMDATDNL KHLQSASFVQ SVTEEAVEAF
     CRDFEFVEGM IIGADEARGR VHIKRTEDGS DAGVEDDVVT ESGKVPDGDE QESGLRRLFP
     RTTGEIRVLL S