ID   COG6_NEUCR              Reviewed;         713 AA.
AC   Q7S4D8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=cog-6; ORFNames=NCU02421;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; CM002242; EAA30367.2; -; Genomic_DNA.
DR   RefSeq; XP_959603.2; XM_954510.3.
DR   AlphaFoldDB; Q7S4D8; -.
DR   STRING; 5141.EFNCRP00000003054; -.
DR   EnsemblFungi; EAA30367; EAA30367; NCU02421.
DR   GeneID; 3875750; -.
DR   KEGG; ncr:NCU02421; -.
DR   VEuPathDB; FungiDB:NCU02421; -.
DR   HOGENOM; CLU_011361_1_0_1; -.
DR   InParanoid; Q7S4D8; -.
DR   OMA; RFYQQIM; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..713
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000339326"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   713 AA;  79377 MW;  28594E94F02DFF37 CRC64;
     MLTGSTSAPP VRSLVLSPRD SSELLSPTGP LTPASTKGAG TSALSSKIAS VLSTSYADTE
     FREALFLLDE RGLQNVAENR RKLRLDLQKE VIDSNGEIIH EFGKVAEQLK RIGYTIGKLN
     ESYNDMRTQI HAAHASTAST LGEASQLMTQ KRQIESKQKL LSTFKTHFIL TQDEVDALTL
     TSEPVDDLFF TVLAKAKKIS RDCEVLLGFE DQTLGLGIME QVTRNLNHGF QKLYRWIQRE
     FKSLNLENPQ IGSAIRRALR VLAERPTLFQ NCLDFFAEAR EHVLSEAFYT ALTGSSAAGL
     EDPSVKPIEL VAHDPLRYVG DMLAWSHSAA VGEREALEVL FISEGDEIAK GIQVGREAEV
     WRLVAEDGEE MNIFDPVVAL NQLVDRDMSG AVRILRQRVE QVIQTNEETI LAFKLANLIN
     FYKSTFSRLV GPASILVEAM GTLETEALRQ FRSLARDHVA TLQTEFQHTP PDLRPPDFLT
     DALEQLSAIM KTYETSLSSS GDDPEAEFAS IMAEAFDPFM AGCINMANHA TPPSKSIFLI
     NCFVAARTTL SGFTFVRKYA ADIQTKIEEE KARLVIAQYE LFRAESGLDS LIEALDGLDI
     RKKDDVGKVA TLEEVQPEAL RQSSQKLDDF LPSALIDATE KLKNLQDSKL ASSVIEEAAE
     RFCVDFEHVE EMLLSADELE EQRRVEEDGD EEHSQSFRAL FPRTSSEIRV LLS