ID   COG6_PICGU              Reviewed;         747 AA.
AC   A5DK56;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=COG6; ORFNames=PGUG_03657;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; CH408158; EDK39559.2; -; Genomic_DNA.
DR   RefSeq; XP_001484276.1; XM_001484226.1.
DR   AlphaFoldDB; A5DK56; -.
DR   SMR; A5DK56; -.
DR   STRING; 4929.XP_001484276.1; -.
DR   PRIDE; A5DK56; -.
DR   EnsemblFungi; EDK39559; EDK39559; PGUG_03657.
DR   GeneID; 5126206; -.
DR   KEGG; pgu:PGUG_03657; -.
DR   VEuPathDB; FungiDB:PGUG_03657; -.
DR   eggNOG; KOG3758; Eukaryota.
DR   HOGENOM; CLU_017837_0_0_1; -.
DR   InParanoid; A5DK56; -.
DR   OMA; RFYQQIM; -.
DR   OrthoDB; 1370285at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IEA:InterPro.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..747
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000339328"
SQ   SEQUENCE   747 AA;  85240 MW;  BA747FFF1DCF8B64 CRC64;
     MDFVDFDTLN LSDDLPQPQR ALSLPIATNI ETFGRKFYNL NSLTRNLLKR DNNTDTEKSE
     NQPQVAEKYA NLSLSLIEDT KNADNDHQEP HSDIKISALS ARLSRVLNNP LSDSQIRQIF
     GSLEDTLRSW DSILEPGALG SMSRRKLRGE IERTLIRNQT QTLKEYQPVI KNLRKLEENV
     DALRSASMGV VDSVNNDFES SEIFNSKMEN LHRKKTAVVV KKQLLSAFRA KFTLNEYEEY
     TLENGDISDE FFTVLAKAEQ VDQNCSILLS IDNSQLGVKT MARVNRLVTR ASEKVVAYAN
     RTLGNLYALN NRDRVRTLHQ CFVYLRHRPH YLNSVLATFV GSRSKTLVDE FLGQANSRVA
     GSSPQSEEYQ DPVRVIGDLL AYIHSVVVSE SETISGIFSF ENDSVDETSR KEFGEIMNDC
     VAKVLQSLAK PVRAKLEQII SREVRISVLF SIHHLAELYY IMFSKQIKQD HMGLVATIES
     LVESAELRIV TTVENKLTTI RNSNSAQLQL NIDLQPPEWI IDFYSEILPM LDQTHTESIF
     KDNSLVNMVV DQPIQIYEQH MENSQVKNFE KRDKYILQLN CLDLILSKIM PISVLTDKVI
     LVNEKIKEVS DKLVETQVSS LLEESGLTDF YNIVNMICPI NDDFFDVSIY EPITENKLFT
     EDNIRQVNSK IQAFLPTALL DIQQSLFKIN SPLVVNEIIT ESAIKYSRFY GRFQLICDEY
     LKVPLLAWSD GEVATLLGVE DAYFDEQ