ID   COG6_RAT                Reviewed;         657 AA.
AC   Q68FP9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=Cog6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for normal Golgi function. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC       composed of eight different subunits and is required for normal Golgi
CC       morphology and localization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; BC079442; AAH79442.1; -; mRNA.
DR   RefSeq; NP_001004262.1; NM_001004262.1.
DR   AlphaFoldDB; Q68FP9; -.
DR   STRING; 10116.ENSRNOP00000018385; -.
DR   PhosphoSitePlus; Q68FP9; -.
DR   jPOST; Q68FP9; -.
DR   PaxDb; Q68FP9; -.
DR   PRIDE; Q68FP9; -.
DR   GeneID; 310411; -.
DR   KEGG; rno:310411; -.
DR   UCSC; RGD:1303283; rat.
DR   CTD; 57511; -.
DR   RGD; 1303283; Cog6.
DR   VEuPathDB; HostDB:ENSRNOG00000013660; -.
DR   eggNOG; KOG3758; Eukaryota.
DR   HOGENOM; CLU_011361_3_0_1; -.
DR   InParanoid; Q68FP9; -.
DR   OMA; RFYQQIM; -.
DR   OrthoDB; 1370285at2759; -.
DR   PhylomeDB; Q68FP9; -.
DR   TreeFam; TF314527; -.
DR   Reactome; R-RNO-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-RNO-6811438; Intra-Golgi traffic.
DR   Reactome; R-RNO-6811440; Retrograde transport at the Trans-Golgi-Network.
DR   PRO; PR:Q68FP9; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000013660; Expressed in testis and 19 other tissues.
DR   Genevisible; Q68FP9; RN.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; ISO:RGD.
DR   GO; GO:0070085; P:glycosylation; ISS:UniProtKB.
DR   GO; GO:0007030; P:Golgi organization; ISO:RGD.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; ISO:RGD.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..657
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000328218"
FT   REGION          14..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   657 AA;  72957 MW;  C1E839B96B395A3D CRC64;
     MADTSGEVAA VPASGAANGL SNGAGATPAQ PNNPLSRKLH KILETRLEND KEMLEALKAL
     SAFFVENSLR TRRNLRGDIE RRSLAINEEF VSIFKDVKEE LESINEDVQA MSSCCQDMTS
     RLQAAKEQTQ DLIVKTTKLQ AENQRLEIRA QVADAFLSKF QLTSDEMTLL RGTRGGPVTE
     DFFKALGRVK QIHNDVKVLL RTNQQTAGLE IMEQMALLQE TAYERLYRWA QSECRALTQE
     SCDVSAVLTQ AMEALQDRPV LYKYTLDEFG TARRSTVVRG FIDALTRGGP GGTPRPIEMH
     SHDPLRYVGD MLAWLHQATA SEKEHLEALL KHVTAQGVKE NIQEVVGHIT EGVCRPLKVR
     IEQVILAEPG AVLLYKISNL LKFYHHTISG IVGNSAATLL TTIEEMHLLS KKIFFSSLSL
     HANKLMDKIE LPPPDLGPSS ALSQTLTLLR DVLASHDSSV VPLDARQADF VQVLSCVLDP
     LLQMCTVSAS NLGTADMATF MVNSLYMMKT TLALFEFTDR RLEMLQFQIE AHLDTLINEQ
     ASYVLTRVGL SYIYNTIQQH RPDQGSLASM PNLDSVALKA AMAQFDRYLS APDHLLMPQL
     NSLLSATVKE QIIKQSTELV CRAYGEVHAA VMNPVNAYKD PESILHRSPE QVKTLLS