COG6_SCHPO
ID COG6_SCHPO Reviewed; 675 AA.
AC O94677;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE Short=COG complex subunit 6;
DE AltName: Full=Component of oligomeric Golgi complex 6;
GN Name=cog6; ORFNames=SPBC776.10c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC is involved in intra-Golgi protein trafficking. COG is located at the
CC cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC and possibly a number of other membrane trafficking events (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}. Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}. Note=Localizes at the
CC barrier septum.
CC -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA22883.1; -; Genomic_DNA.
DR PIR; T40680; T40680.
DR RefSeq; NP_596325.1; NM_001022247.2.
DR AlphaFoldDB; O94677; -.
DR BioGRID; 277721; 3.
DR STRING; 4896.SPBC776.10c.1; -.
DR MaxQB; O94677; -.
DR PaxDb; O94677; -.
DR EnsemblFungi; SPBC776.10c.1; SPBC776.10c.1:pep; SPBC776.10c.
DR GeneID; 2541207; -.
DR KEGG; spo:SPBC776.10c; -.
DR PomBase; SPBC776.10c; cog6.
DR VEuPathDB; FungiDB:SPBC776.10c; -.
DR eggNOG; KOG3758; Eukaryota.
DR HOGENOM; CLU_011361_1_0_1; -.
DR InParanoid; O94677; -.
DR OMA; RFYQQIM; -.
DR PhylomeDB; O94677; -.
DR PRO; PR:O94677; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISO:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR InterPro; IPR010490; COG6.
DR PANTHER; PTHR21506; PTHR21506; 1.
DR Pfam; PF06419; COG6; 1.
DR SMART; SM01087; COG6; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Golgi apparatus; Membrane; Nucleus; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..675
FT /note="Conserved oligomeric Golgi complex subunit 6"
FT /id="PRO_0000339330"
SQ SEQUENCE 675 AA; 77327 MW; 459745B0DE518EC0 CRC64;
MDVKSKHGHI KSNPEESLLF RNSVSKNIAQ LSSINYADRN VQAALEQLSE RKFKNEREAR
KQLPFEVFSD LIWTNGSIIK ELSELSSQTL SVQSQLLKVK NSIDSYKNEW SKKTNDAQIL
LNSYETFCEE EALIEEKLKN IEIFEKNFVI MDDDLIHLTS STDVDDRFYL ILDKAQEIHD
SSDSLFASLS GFVEYSSFEE IVKKMSRYIE AAFEKLFRCV QTELSDPQTA QTLEANSHLK
KAFTKLFSEP TMVNKSINLI VQARQQILST AYLTALTRGD FLSSSRPIEL SAPDTVRFIG
DLLAWIHQTI VNEKELVEAL FAARKRQIQL NPFPPWDVPN VLEDQMNSLL DGSLYGICRP
LSSRAQTSVL DLSDIVRLYN VIEILGFYRE AFSKIVHDEC IILRIIKTLE DFTYQRMKTV
LDDELYTISN TNLSITDDLL PPDFVTTFLR NANSIFKIRG ASLSVQGVDE LPFKMLFMQL
FDRILEICAA MTEDVRPPYK GIILMLNVLD SCTNYVGRYT FLNELFEYLQ EKTTYYKNNL
TTLLNNDYIA QAGLSDLLQK IADTTDDKQA LKNYLHSWKW DQQIDKFSTF IRKTLSETID
NLQLLTSPIV TNQVLKETAI SFVGAIETVD KALELSNLER RWPLSTEELL IAMNVDSMDT
LSDIGQSDID NLSVN
