ID   COG6_VANPO              Reviewed;         825 AA.
AC   A7THG4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
GN   Name=COG6; ORFNames=Kpol_1039p38;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; DS480391; EDO18288.1; -; Genomic_DNA.
DR   RefSeq; XP_001646146.1; XM_001646096.1.
DR   AlphaFoldDB; A7THG4; -.
DR   SMR; A7THG4; -.
DR   STRING; 436907.A7THG4; -.
DR   EnsemblFungi; EDO18288; EDO18288; Kpol_1039p38.
DR   GeneID; 5546568; -.
DR   KEGG; vpo:Kpol_1039p38; -.
DR   eggNOG; KOG3758; Eukaryota.
DR   HOGENOM; CLU_017837_0_0_1; -.
DR   InParanoid; A7THG4; -.
DR   OMA; IINMICP; -.
DR   OrthoDB; 1370285at2759; -.
DR   PhylomeDB; A7THG4; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IEA:InterPro.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..825
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000339332"
SQ   SEQUENCE   825 AA;  94458 MW;  EB52632023A8ABD4 CRC64;
     MEFIDYDTFG VSDTISTSAG DGALPEPVAI LNLNALSFEK PDEHNEINLS ELLVDRGTTD
     GGKNVNLNAK MSNYAKLSME SLHISGTSDN LSVNTLPSYI PDGNKESLDI SKLVFQQKNQ
     SLEATNMILN KKLSKILNDY SFSNYQSTSY LRKSLNSLEE NKVALSLDEN KLTNPGYIGT
     LARKTLKSDV ETELLKEHLT VLEEFRPIVR KIKKLSSSIE NIQNLGTSML KESKENATGT
     EEPMFDRIKS LRKDIDNLKL KKELLLSIRD QYTLTQVEDD KISNGSVDEE LFEIINKVMR
     IKEKTVFMLG LENPNAGKSL MHEVNNILQR LNRKLFNHLL DILYIFESGT NNVNEKFLSP
     NEKGVQTFQR SLIYLSNDLE YFNEFLKRVT SLRSKTVLDQ FLSQFDFNSK DANPIMLSAY
     DPLRYIGDIL ANVYSLIANE ADFVRSLFNF QEMQMENTPV SIIQKKDEFL DGLDSKLLNE
     IIQSLSNTCR IRIGQIIKFE DNPITNFEIV KLLELYKMMF ERKGIKSNSS LINNLSALGV
     VSQEKLIECY SNFVNEIEKT TYVATEDFLP PEWLSDYLVK ITDLFEAYEQ HGGRESDTNE
     IIITDTFLEK VIKEPIENTL LKQLKEGFPL AKKEEQARTS LYTVQINCFD LIKSRIQPFA
     SVIFSKDGEK NDVLKWISDK SEEVINQMLE LQKKILFDKT GLGMYNNLLN MIFPISSVKD
     DLDLDMYYSL SENSLMNLDS INTNVHEKLN DYVPIALTDM QGNLLFKLTS PVIADKICDS
     CFSTLSEFYI TFRKTLMHIY PEEEIKIKEI LNFSEEEFKT LVGIE