ID   COG6_YEAS7              Reviewed;         839 AA.
AC   A6ZS37;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE            Short=COG complex subunit 6;
DE   AltName: Full=Complexed with DOR1 protein 2;
DE   AltName: Full=Component of oligomeric Golgi complex 6;
DE   AltName: Full=Protein SEC37;
GN   Name=COG6; Synonyms=COD2, SEC37, TFI2; ORFNames=SCY_4748;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC       is involved in intra-Golgi protein trafficking. COG is located at the
CC       cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC       and possibly a number of other membrane trafficking events (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
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DR   EMBL; AAFW02000067; EDN62769.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZS37; -.
DR   SMR; A6ZS37; -.
DR   PRIDE; A6ZS37; -.
DR   EnsemblFungi; EDN62769; EDN62769; SCY_4748.
DR   HOGENOM; CLU_017837_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IEA:InterPro.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010490; COG6.
DR   PANTHER; PTHR21506; PTHR21506; 1.
DR   Pfam; PF06419; COG6; 1.
DR   SMART; SM01087; COG6; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Transport.
FT   CHAIN           1..839
FT                   /note="Conserved oligomeric Golgi complex subunit 6"
FT                   /id="PRO_0000339333"
SQ   SEQUENCE   839 AA;  96931 MW;  793E210C560AAB0D CRC64;
     MDFVVDYQTY AMADTAAPEL PEPEPRLNLT SDAQSQPTGI LDLQFKLPDL QRYSNNNATL
     PVDNDGAGSK DLHKKMTHYA MSSIDKIQLS NPSKQLGQNS QDEKLSQQES QNFTNYEPKN
     LDLSKLVSPS SGSNKNTTNL VLSNKLSKIL NNYTLINYQA TVQLRKSLKV LEENKERLSL
     DEQKLMNPEY VGTLARRALR TDLESQLLKE HITVLEEFKP IIRRIKRLSS SVEKIQRTSE
     KLLSNETNEV PTNNVVLQEI DQYRLKAEQL KLKKKILLSI RDRFTLNQVE DDVITNGTID
     NIFFEVVKKV INIKDESSFL LTLPNLNAGN ALIMGVNEIL EKTNKKIFNY LIDFLYSFES
     SSNLLNDHGT TEQESLNIFR KSLVFLSSDL ELFNELLKRV TTLRSKSILD EFLSQFDMNS
     TTSKPIILSA HDPIRYIGDV LASVHSIIAN EADFVKSLFD FQDEDLKDTP ISILQQNKTF
     LKGIDNKLLN DIIQSLSNSC RIRIEQIVRF EENPIINFEI VRLLKLYRVM FERKGIQDDS
     SIINNLKSLE DISKNRIIGY YEDYMKQTVM AETKNSSDDL LPPEWLSEYM NKLVELFEIY
     EKTHAAEDEE SEDNKLLSSK NLQTIVEQPI KDVLLKQLQT SFPLAKKNEK EKASLLTIEI
     NCFDLIKSRL QPFEGLFAQD DDSRKITIWV CDKLKEYTKQ MLTLQIKFLF ENTGLDLYSN
     LVNMIFPVDS VKDELDYDMY LALRDNSLME LDMVRKNVHD KLNYYLPQAL TDVQGNLLFK
     LTSPMIADEI CDECFKKLSL FYNIFRKLLI HLYPNKKDQV FEILNFSTDE FDMLIGIDH