COG6_YEAST
ID COG6_YEAST Reviewed; 839 AA.
AC P53959; D6W1D8;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 6;
DE Short=COG complex subunit 6;
DE AltName: Full=Complexed with DOR1 protein 2;
DE AltName: Full=Component of oligomeric Golgi complex 6;
DE AltName: Full=Protein SEC37;
GN Name=COG6; Synonyms=COD2, SEC37, TFI2; OrderedLocusNames=YNL041C;
GN ORFNames=N2675;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP SUBUNIT.
RX PubMed=11703943; DOI=10.1016/s1534-5807(01)00063-6;
RA Whyte J.R., Munro S.;
RT "The Sec34/35 Golgi transport complex is related to the exocyst, defining a
RT family of complexes involved in multiple steps of membrane traffic.";
RL Dev. Cell 1:527-537(2001).
RN [4]
RP IDENTIFICATION IN THE COG COMPLEX, AND FUNCTION OF THE COG COMPLEX.
RX PubMed=12011112; DOI=10.1083/jcb.200111081;
RA Suvorova E.S., Duden R., Lupashin V.V.;
RT "The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-
RT Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat
RT proteins.";
RL J. Cell Biol. 157:631-643(2002).
RN [5]
RP FUNCTION, AND IDENTIFICATION IN THE COG COMPLEX.
RX PubMed=12006647; DOI=10.1091/mbc.01-10-0495;
RA Ram R.J., Li B., Kaiser C.A.;
RT "Identification of sec36p, sec37p, and sec38p: components of yeast complex
RT that contains sec34p and sec35p.";
RL Mol. Biol. Cell 13:1484-1500(2002).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP COMPOSITION OF THE COG COMPLEX, AND INTERACTION WITH COG3 AND COG4.
RX PubMed=15047703; DOI=10.1074/jbc.m400662200;
RA Loh E., Hong W.;
RT "The binary interacting network of the conserved oligomeric Golgi tethering
RT complex.";
RL J. Biol. Chem. 279:24640-24648(2004).
CC -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC is involved in intra-Golgi protein trafficking. COG is located at the
CC cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC and possibly a number of other membrane trafficking events.
CC {ECO:0000269|PubMed:12006647, ECO:0000269|PubMed:12011112}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi (COG or
CC Sec34/Sec35) complex which consists of eight different proteins COG1-
CC COG8. {ECO:0000269|PubMed:11703943, ECO:0000269|PubMed:12006647,
CC ECO:0000269|PubMed:12011112}.
CC -!- INTERACTION:
CC P53959; P53079: COG1; NbExp=5; IntAct=EBI-4829, EBI-4835;
CC P53959; P53271: COG2; NbExp=3; IntAct=EBI-4829, EBI-16614;
CC P53959; P40094: COG3; NbExp=3; IntAct=EBI-4829, EBI-16605;
CC P53959; P53951: COG5; NbExp=2; IntAct=EBI-4829, EBI-4841;
CC P53959; P53195: COG7; NbExp=3; IntAct=EBI-4829, EBI-4847;
CC P53959; Q04632: COG8; NbExp=5; IntAct=EBI-4829, EBI-6035;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: Present with 1720 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the COG6 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z71317; CAA95908.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10504.1; -; Genomic_DNA.
DR PIR; S62963; S62963.
DR RefSeq; NP_014357.1; NM_001182880.1.
DR AlphaFoldDB; P53959; -.
DR SMR; P53959; -.
DR BioGRID; 35783; 532.
DR ComplexPortal; CPX-1840; COG Golgi transport complex.
DR DIP; DIP-4373N; -.
DR IntAct; P53959; 18.
DR MINT; P53959; -.
DR STRING; 4932.YNL041C; -.
DR iPTMnet; P53959; -.
DR MaxQB; P53959; -.
DR PaxDb; P53959; -.
DR PRIDE; P53959; -.
DR EnsemblFungi; YNL041C_mRNA; YNL041C; YNL041C.
DR GeneID; 855687; -.
DR KEGG; sce:YNL041C; -.
DR SGD; S000004986; COG6.
DR VEuPathDB; FungiDB:YNL041C; -.
DR eggNOG; KOG3758; Eukaryota.
DR GeneTree; ENSGT00390000013518; -.
DR HOGENOM; CLU_017837_0_0_1; -.
DR InParanoid; P53959; -.
DR OMA; IINMICP; -.
DR BioCyc; YEAST:G3O-33077-MON; -.
DR PRO; PR:P53959; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P53959; protein.
DR GO; GO:0000139; C:Golgi membrane; IC:ComplexPortal.
DR GO; GO:0017119; C:Golgi transport complex; IMP:SGD.
DR GO; GO:0032258; P:cytoplasm to vacuole transport by the Cvt pathway; IMP:SGD.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IMP:SGD.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; IC:ComplexPortal.
DR InterPro; IPR010490; COG6.
DR PANTHER; PTHR21506; PTHR21506; 1.
DR Pfam; PF06419; COG6; 1.
DR SMART; SM01087; COG6; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..839
FT /note="Conserved oligomeric Golgi complex subunit 6"
FT /id="PRO_0000213517"
FT REGION 14..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 839 AA; 96976 MW; 6484A40F999AD787 CRC64;
MDFVVDYQTY AMADTATPEL PEPEPRLNLT SDAQSQPTGK LDLQFKLPDL QRYSNNNATL
PVDNDGAGSK DLHKKMTHYA MSSIDKIQLS NPSKQLGQNS QDEKLSQQES QNFTNYEPKN
LDLSKLVSPS SGSNKNTTNL VLSNKLSKIL NNYTLINYQA TVQLRKSLKV LEENKERLSL
DEQKLMNPEY VGTLARRALR TDLESQLLKE HITVLEEFKP IIRRIKRLSS SVEKIQRTSE
KLLSNETNEV PTNNVVLQEI DQYRLKAEQL KLKKKILLSI RDRFTLNQVE DDVITNGTID
NIFFEVVKKV INIKDESSFL LTLPNLNAGN ALIMGVNEIL EKTNKKIFNY LIDFLYSFES
SSNLLNDHGT TEQESLNIFR KSLVFLSSDL ELFNELLKRV TTLRSKSILD EFLSQFDMNS
TTSKPIILSA HDPIRYIGDV LASVHSIIAN EADFVKSLFD FQDEDLKDTP ISILQQNKTF
LKGIDNKLLN DIIQSLSNSC RIRIEQIVRF EENPIINFEI VRLLKLYRVM FERKGIQDDS
SIINNLKSLE DISKNRIIGY YEDYMKQTVM AETKNSSDDL LPPEWLSEYM NKLVELFEIY
EKTHAAEDEE SEDNKLLSSK NLQTIVEQPI KDVLLKQLQT SFPLAKKNEK EKASLLTIEI
NCFDLIKSRL QPFEGLFAQD DDSRKITIWV CDKLKEYTKQ MLTLQIKFLF ENTGLDLYSN
LVNMIFPVDS VKDELDYDMY LALRDNSLME LDMVRKNVHD KLNYYLPQAL TDVQGNLLFK
LTSPMIADEI CDECFKKLSL FYNIFRKLLI HLYPNKKDQV FEILNFSTDE FDMLIGIDH
