COG7_MOUSE
ID COG7_MOUSE Reviewed; 770 AA.
AC Q3UM29; Q3U3L7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 7;
DE Short=COG complex subunit 7;
DE AltName: Full=Component of oligomeric Golgi complex 7;
GN Name=Cog7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Mammary gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for normal Golgi function.
CC {ECO:0000250|UniProtKB:P83436}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250|UniProtKB:P83436}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:P83436}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P83436}.
CC -!- SIMILARITY: Belongs to the COG7 family. {ECO:0000305}.
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DR EMBL; AK145163; BAE26269.1; -; mRNA.
DR EMBL; AK154693; BAE32768.1; -; mRNA.
DR CCDS; CCDS21805.1; -.
DR RefSeq; NP_001028490.2; NM_001033318.3.
DR AlphaFoldDB; Q3UM29; -.
DR BioGRID; 231453; 3.
DR STRING; 10090.ENSMUSP00000058990; -.
DR iPTMnet; Q3UM29; -.
DR PhosphoSitePlus; Q3UM29; -.
DR EPD; Q3UM29; -.
DR jPOST; Q3UM29; -.
DR MaxQB; Q3UM29; -.
DR PaxDb; Q3UM29; -.
DR PeptideAtlas; Q3UM29; -.
DR PRIDE; Q3UM29; -.
DR ProteomicsDB; 283420; -.
DR DNASU; 233824; -.
DR GeneID; 233824; -.
DR KEGG; mmu:233824; -.
DR UCSC; uc009jnz.1; mouse.
DR CTD; 91949; -.
DR MGI; MGI:2685013; Cog7.
DR eggNOG; KOG4182; Eukaryota.
DR InParanoid; Q3UM29; -.
DR OrthoDB; 280917at2759; -.
DR PhylomeDB; Q3UM29; -.
DR TreeFam; TF324498; -.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR Reactome; R-MMU-6811438; Intra-Golgi traffic.
DR Reactome; R-MMU-6811440; Retrograde transport at the Trans-Golgi-Network.
DR BioGRID-ORCS; 233824; 27 hits in 73 CRISPR screens.
DR PRO; PR:Q3UM29; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q3UM29; protein.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0070085; P:glycosylation; ISO:MGI.
DR GO; GO:0007030; P:Golgi organization; ISO:MGI.
DR GO; GO:0006886; P:intracellular protein transport; ISO:MGI.
DR GO; GO:0006486; P:protein glycosylation; ISO:MGI.
DR GO; GO:0034067; P:protein localization to Golgi apparatus; ISO:MGI.
DR GO; GO:0033365; P:protein localization to organelle; ISO:MGI.
DR GO; GO:0050821; P:protein stabilization; ISO:MGI.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; ISO:MGI.
DR GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; ISO:MGI.
DR InterPro; IPR019335; COG7.
DR PANTHER; PTHR21443; PTHR21443; 1.
DR Pfam; PF10191; COG7; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..770
FT /note="Conserved oligomeric Golgi complex subunit 7"
FT /id="PRO_0000320147"
FT CONFLICT 195
FT /note="A -> S (in Ref. 1; BAE32768)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="A -> G (in Ref. 1; BAE32768)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 770 AA; 86073 MW; 2DDE4F0E0923AB38 CRC64;
MDFSKFLADD FDVKDWINAA FRAGPKDGAA GKADGHAATL VMKLQLFIQE VNHAVEETSL
QALQNMPKVL RDVEALKQEA SFLKEQMILV KEDIKKFEQD TSQSMQVLVE IDQVKSRMQL
AAESLQEADK WSTLSADIEE TFKTQDIAVI SAKLTGMQNS LMMLVDTPDY SEKCVHLEAL
KNRLEALASP QIVAAFTSQS VDQSKVFVKV FTEIDRMPQL LAYYYKCHKV QLLATWQELC
QSDLPLDRQL TGLYDALLGA WHTQTQWATQ VFKNPHEVVT VLLIQTLGAL VPSLPMCLSA
AVERAGPELE LTRLLEFYDT TAHFAKGLEM ALLPHLQDHN LVKVVELVDA VYGPYKPFQL
KYGDMEENNL LIQISAVPLE HGEVIDCVQE LSHSVHKLFG LASAAVDRCA KFTNGLGTCG
LLTALKSLFA KYVSHFTNAL QSIRKKCKLD DIPPNSLFQE DWTAFQNSVR IIATCGELLR
QCGDFEQQLA NRILSTAGKY LSDSYSPRSL AGFQDSILTD KKSPAKNPWQ EYNYLQKDNP
AEYASLMEIL YTLKEKGSSN HNLLSASRTA LTRLNQQAHQ LAFDSVFLRI KQQLLLVSRM
DSWNTAGIGE TLTDDLPAFS LTPLEYISNI GQYIMSLPLN LEPFVTQEDS ALELALHAGK
LPFPPEQGDE LPELDNMADN WLGSIARATM QTYCDVILQI PEVTPHSTKQ LATDIDYLIN
VMDALGLQPS RTLQNIAALL KAKPEEYRQV SKGLPRRLAA TVATMRGVNY
