COG7_YEAST
ID COG7_YEAST Reviewed; 279 AA.
AC P53195; D6VUD3; E9P921;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 7;
DE Short=COG complex subunit 7;
DE AltName: Full=Complexed with DOR1 protein 5;
DE AltName: Full=Component of oligomeric Golgi complex 7;
GN Name=COG7; Synonyms=COD5; OrderedLocusNames=YGL005C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBUNIT.
RX PubMed=11703943; DOI=10.1016/s1534-5807(01)00063-6;
RA Whyte J.R., Munro S.;
RT "The Sec34/35 Golgi transport complex is related to the exocyst, defining a
RT family of complexes involved in multiple steps of membrane traffic.";
RL Dev. Cell 1:527-537(2001).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP COMPOSITION OF THE COG COMPLEX, AND INTERACTION WITH COG4.
RX PubMed=15047703; DOI=10.1074/jbc.m400662200;
RA Loh E., Hong W.;
RT "The binary interacting network of the conserved oligomeric Golgi tethering
RT complex.";
RL J. Biol. Chem. 279:24640-24648(2004).
CC -!- FUNCTION: Acts as component of the peripheral membrane COG complex that
CC is involved in intra-Golgi protein trafficking. COG is located at the
CC cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles
CC and possibly a number of other membrane trafficking events.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi (COG or
CC Sec34/Sec35) complex which consists of eight different proteins COG1-
CC COG8. {ECO:0000269|PubMed:11703943}.
CC -!- INTERACTION:
CC P53195; P53271: COG2; NbExp=2; IntAct=EBI-4847, EBI-16614;
CC P53195; P40094: COG3; NbExp=2; IntAct=EBI-4847, EBI-16605;
CC P53195; Q06096: COG4; NbExp=2; IntAct=EBI-4847, EBI-4823;
CC P53195; P53951: COG5; NbExp=6; IntAct=EBI-4847, EBI-4841;
CC P53195; P53959: COG6; NbExp=3; IntAct=EBI-4847, EBI-4829;
CC P53195; Q04632: COG8; NbExp=2; IntAct=EBI-4847, EBI-6035;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: Present with 1360 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z72527; CAA96705.1; -; Genomic_DNA.
DR EMBL; AY693131; AAT93150.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08094.1; -; Genomic_DNA.
DR PIR; S64007; S64007.
DR RefSeq; NP_011510.1; NM_001180870.1.
DR AlphaFoldDB; P53195; -.
DR SMR; P53195; -.
DR BioGRID; 33240; 364.
DR ComplexPortal; CPX-1840; COG Golgi transport complex.
DR DIP; DIP-4580N; -.
DR IntAct; P53195; 8.
DR MINT; P53195; -.
DR STRING; 4932.YGL005C; -.
DR iPTMnet; P53195; -.
DR MaxQB; P53195; -.
DR PaxDb; P53195; -.
DR PRIDE; P53195; -.
DR EnsemblFungi; YGL005C_mRNA; YGL005C; YGL005C.
DR GeneID; 852879; -.
DR KEGG; sce:YGL005C; -.
DR SGD; S000002973; COG7.
DR VEuPathDB; FungiDB:YGL005C; -.
DR eggNOG; ENOG502RXQM; Eukaryota.
DR HOGENOM; CLU_086134_0_0_1; -.
DR InParanoid; P53195; -.
DR OMA; TTKLEYY; -.
DR BioCyc; YEAST:G3O-30529-MON; -.
DR PRO; PR:P53195; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53195; protein.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0000139; C:Golgi membrane; IC:ComplexPortal.
DR GO; GO:0017119; C:Golgi transport complex; IMP:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0032258; P:cytoplasm to vacuole transport by the Cvt pathway; IMP:SGD.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IMP:SGD.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; IC:ComplexPortal.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..279
FT /note="Conserved oligomeric Golgi complex subunit 7"
FT /id="PRO_0000213520"
FT CONFLICT 12
FT /note="D -> G (in Ref. 3; AAT93150)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 279 AA; 31775 MW; A72B39889DC74625 CRC64;
MVELTITGDD DDILSMFFDE EFVPHAFVDI LLSNALNEDQ IQTQSVSSLL LTRLDFYTKN
LTKELESTIW NLDKLSQTLP RTWASSRYHK EAEQNDSSLY STESLKSSKL EYYLDTLASA
VRALETGMHN VTEKLSDLDN ENNRNTNVRQ QLQSLMLIKE RIEKVVYYLE QVRTVTNIST
VRENNTTSTG TDLSITDFRT SLKALEDTID ESLSSAIDNE AKDETNKDLI GRIDSLSELK
CLFKGLDKFF AEYSNFSESI KSKAQSYLST KNIDDGMIS
