ID   COG8_CAEEL              Reviewed;         743 AA.
AC   O44502;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Conserved oligomeric Golgi complex subunit 8;
DE            Short=COG complex subunit 8;
DE   AltName: Full=Component of oligomeric Golgi complex 8;
GN   Name=cogc-8; ORFNames=R02D3.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for normal Golgi function. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC       composed of eight different subunits and is required for normal Golgi
CC       morphology and localization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the COG8 family. {ECO:0000305}.
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DR   EMBL; FO081663; CCD73166.1; -; Genomic_DNA.
DR   PIR; T15062; T15062.
DR   RefSeq; NP_499883.1; NM_067482.3.
DR   AlphaFoldDB; O44502; -.
DR   SMR; O44502; -.
DR   BioGRID; 42003; 3.
DR   IntAct; O44502; 1.
DR   STRING; 6239.R02D3.2; -.
DR   EPD; O44502; -.
DR   PaxDb; O44502; -.
DR   PeptideAtlas; O44502; -.
DR   EnsemblMetazoa; R02D3.2.1; R02D3.2.1; WBGene00019820.
DR   GeneID; 176841; -.
DR   KEGG; cel:CELE_R02D3.2; -.
DR   UCSC; R02D3.2; c. elegans.
DR   CTD; 176841; -.
DR   WormBase; R02D3.2; CE18096; WBGene00019820; cogc-8.
DR   eggNOG; KOG2069; Eukaryota.
DR   GeneTree; ENSGT00390000015893; -.
DR   HOGENOM; CLU_017968_1_0_1; -.
DR   InParanoid; O44502; -.
DR   OMA; QRCIHGV; -.
DR   OrthoDB; 1531483at2759; -.
DR   PhylomeDB; O44502; -.
DR   Reactome; R-CEL-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-CEL-6811438; Intra-Golgi traffic.
DR   PRO; PR:O44502; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00019820; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR   GO; GO:0035262; P:gonad morphogenesis; IMP:WormBase.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0030334; P:regulation of cell migration; IMP:WormBase.
DR   InterPro; IPR007255; COG8.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   PANTHER; PTHR21311; PTHR21311; 1.
DR   Pfam; PF04124; Dor1; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..743
FT                   /note="Conserved oligomeric Golgi complex subunit 8"
FT                   /id="PRO_0000213523"
FT   REGION          549..672
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          704..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        560..622
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        637..670
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        704..727
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        728..743
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  83844 MW;  90371D9EE7B5F7DF CRC64;
     MDSDYIFHNG DDIRNMGLEE MRRQKVLLAS ELKAIDAQIS DLAFNNYGTY ADAGRATHDC
     SKTFGEMRDK TVNLSDQAEE LTSAFVEFRA KAKQLSEEQD LVRKALDKSN PIWELLTLPS
     RMDICIRAGY YDLAYTLTNY GLQLQQQTQL YRNPLIKKVA DHLVEARAYL LEELFNKFAG
     PLDLAESIKV VNNVRKMPSL TANQLRIAVL QHRDIYLEKQ ILDISGNVDM IVQAIEIYRT
     SMYDTLVLYL AVFPENEVVR KNPNADPRWE SWPVLPPNSI LSQWVISNVK KMLDLITKAD
     VKSAVDLSAV WTKLMAMASS FGRMGIDFRP LIAGKLTKLI EQRFRQNVQE ATSRLTGSSR
     DIVMIGIDPA SLPQFETAPD SPPVAAAELS LWDDMTIYTN SVVDALNGLR FILTPVVLST
     VVVSLRDSIR SILTWLASSH SNSANFSRAV RIVCTSVAPF FEKCVAFFFP PATVSKIFGS
     SISKRQYLQF IELDMKQLAA SCDGAEKIEE IVKPLLQKRT LEEIGLENVL KPTKPEEEKT
     KFFLEETVED GPGLAEPQEE ASESVKEQET TSELEKKHGT DFETAETQEM VSEPVKEHET
     TSELTKEQEP AFEPEKLHET PPEPMEPQNF GESEAKAAHN PEAHLELGET SENQEIREQE
     HKEVVITSTE PEFHEIDLNS AVLIPKIAVE PQLDPISEYL TELTQDDPIE EEEGWGWGDD
     DGEEQEISSK EVESPKEKCK KDD