COG8_DICDI
ID COG8_DICDI Reviewed; 779 AA.
AC Q55BB8;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 8;
DE Short=COG complex subunit 8;
DE AltName: Full=Component of oligomeric Golgi complex 8;
GN Name=cog8; ORFNames=DDB_G0271388;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Required for normal Golgi function. {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG8 family. {ECO:0000305}.
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DR EMBL; AAFI02000006; EAL71824.1; -; Genomic_DNA.
DR RefSeq; XP_645694.1; XM_640602.1.
DR AlphaFoldDB; Q55BB8; -.
DR SMR; Q55BB8; -.
DR STRING; 44689.DDB0216803; -.
DR PaxDb; Q55BB8; -.
DR EnsemblProtists; EAL71824; EAL71824; DDB_G0271388.
DR GeneID; 8617887; -.
DR KEGG; ddi:DDB_G0271388; -.
DR dictyBase; DDB_G0271388; cog8.
DR eggNOG; KOG2069; Eukaryota.
DR HOGENOM; CLU_359617_0_0_1; -.
DR InParanoid; Q55BB8; -.
DR OMA; LQYCGMS; -.
DR PhylomeDB; Q55BB8; -.
DR Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DDI-6811438; Intra-Golgi traffic.
DR PRO; PR:Q55BB8; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR007255; COG8.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR PANTHER; PTHR21311; PTHR21311; 1.
DR Pfam; PF04124; Dor1; 1.
DR SUPFAM; SSF74788; SSF74788; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..779
FT /note="Conserved oligomeric Golgi complex subunit 8"
FT /id="PRO_0000341685"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..570
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 87207 MW; BC783CD3988046CF CRC64;
MSKVNTDENN FINNNNSNNN INNNDNNDNN NNNIQNVSNQ IENGLLSNLP TISSSCESFS
SKSHSLTERR SSIKNLLDNF STLLDILEIP QLMDTCIKNN SFDEALQLES FAKKIYKQYS
NNTVIIEIIK EIKVCTRSLI STLQQQLRQD ITLTNCIKTI GYLRRLSIYK ENELKIIFLH
SRDQWLINSL KFDITNSNHV TYLTKLTDSC RTNIFDIVTQ YNAIFSNESN DEDQLDDLIL
YNWIQQKIKV YINIVDSTLN HIKSGSSISY VLENSMYFSM SISRVGIDFR NLLEPIFEKH
ILNNFLSQIT TANHHFLETL KTYKFPLQKS TSPTSSTTST SSSSSSSSSS QYISPPLSIL
QHQPLAVLVN LILKSFNELK DCFPISLRSI VILKLKELII SIVGGVTSFY NQLLSNTISN
LINSPSTTTT TTTTTITSSF DKVFHSFCKC LAEDFIPFIV KCFDIICSQQ LQQQQQINDG
SSSSSSSNSI GIDVDSLVLS LKKIYSTETQ TIPSTQNNNL PPIPDLVLRG NKNSSPSTTT
TPTTPTPTPT PTPTPTPTTP TTPTITHSTP PSPLPSSTTT QLNSNNNNND NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN TDKKVDERKE ENIIKEEEQP
ISTSTANKND IAIETITTPS SFSSSSSTNT KSDEEIIDKI VQPDPVVVEK QENEITNILK
DDNETTTDIL TDNNEATTEI QNNDQSLNPD PIIQEIEDTP SEVIVNNNNN NNDDDDTTF
