COG8_DROME
ID COG8_DROME Reviewed; 570 AA.
AC Q9VKH0; A9UNB2; Q8T9C7;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 8;
DE Short=COG complex subunit 8;
DE AltName: Full=Component of oligomeric Golgi complex 8 {ECO:0000312|FlyBase:FBgn0287204};
GN Name=Cog8 {ECO:0000312|FlyBase:FBgn0287204};
GN ORFNames=CG6488 {ECO:0000312|FlyBase:FBgn0287204};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Larva, and Pupae;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-570.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Required for normal Golgi function. {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG8 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL39970.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAF53099.1; -; Genomic_DNA.
DR EMBL; BT031276; ABY20517.1; -; mRNA.
DR EMBL; AY069825; AAL39970.1; ALT_SEQ; mRNA.
DR RefSeq; NP_609503.2; NM_135659.3.
DR AlphaFoldDB; Q9VKH0; -.
DR SMR; Q9VKH0; -.
DR BioGRID; 60628; 5.
DR DIP; DIP-23800N; -.
DR IntAct; Q9VKH0; 6.
DR STRING; 7227.FBpp0079833; -.
DR PaxDb; Q9VKH0; -.
DR PRIDE; Q9VKH0; -.
DR DNASU; 34571; -.
DR EnsemblMetazoa; FBtr0080248; FBpp0079833; FBgn0287204.
DR GeneID; 34571; -.
DR KEGG; dme:Dmel_CG6488; -.
DR UCSC; CG6488-RA; d. melanogaster.
DR CTD; 84342; -.
DR FlyBase; FBgn0287204; Cog8.
DR VEuPathDB; VectorBase:FBgn0287204; -.
DR eggNOG; KOG2069; Eukaryota.
DR GeneTree; ENSGT00390000015893; -.
DR HOGENOM; CLU_017968_0_0_1; -.
DR InParanoid; Q9VKH0; -.
DR OMA; QRCIHGV; -.
DR OrthoDB; 1531483at2759; -.
DR PhylomeDB; Q9VKH0; -.
DR Reactome; R-DME-6807878; COPI-mediated anterograde transport.
DR Reactome; R-DME-6811438; Intra-Golgi traffic.
DR SignaLink; Q9VKH0; -.
DR BioGRID-ORCS; 34571; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 34571; -.
DR PRO; PR:Q9VKH0; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Genevisible; Q9VKH0; DM.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; IDA:FlyBase.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:FlyBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR007255; COG8.
DR InterPro; IPR016632; COG8_Metazoal_Plant.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR PANTHER; PTHR21311; PTHR21311; 1.
DR Pfam; PF04124; Dor1; 1.
DR PIRSF; PIRSF015415; COG8; 1.
DR SUPFAM; SSF74788; SSF74788; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..570
FT /note="Conserved oligomeric Golgi complex subunit 8"
FT /id="PRO_0000213524"
FT CONFLICT 372
FT /note="S -> N (in Ref. 4; AAL39970)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 570 AA; 64910 MW; F899929F585B47A4 CRC64;
MDFPDKMDLE NERVLKLIFP DGVPDNLRGN PELDNYLAKL GTCKVEQLKK EQTRLAEEAR
TILEQTQDLA ISNYRTFITT AENSRSIFSE FLRSEQQLDT LVSKLPDLSV QCERFLQDSA
ELNEQRRLNS ITLQKNAQLL EVLELPQLME RCIREGRYEE ALELAAYATR LGQHQGHIPV
VTSIVRSVEA LWHNMLVQLV AQLRTDLQLP KCLQIVGYLR RMQAFGDNEL RLKFLQARDA
WLTSCLEAIP TADAQQHLSK TIEITRINLF NIITQYRAIF PEDEGTLKTQ SSLRPLQGVS
CNGDRLFQAW LHNKISDFLQ TLERDLQLGV GSVETVLGQC MYFGLSFSRV GADFRALMAP
IFVGVIRRRF ESSVEQVDEQ FERELERFTL INKVALHSHA RKQVDPEQES YAPPEALLDF
YPLAALCNGY LSALNELRLC APLALATDVT RCLQHSLQQA AQRVLAFYRQ EQQAFAGSER
EAFVRLCSCL AYDLVPYIQR CIHGVFPPQS LTVHLGISLL QLEQQQLTYL QQTRILEPLK
HLLPTKALVQ PQDKVMEAKP SAGVPVTAEG
