COG8_MOUSE
ID COG8_MOUSE Reviewed; 640 AA.
AC Q9JJA2; Q8BFW5;
DT 30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Conserved oligomeric Golgi complex subunit 8;
DE Short=COG complex subunit 8;
DE AltName: Full=Component of oligomeric Golgi complex 8;
GN Name=Cog8; ORFNames=MNCb-5704;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for normal Golgi function. {ECO:0000250}.
CC -!- SUBUNIT: Component of the conserved oligomeric Golgi complex which is
CC composed of eight different subunits and is required for normal Golgi
CC morphology and localization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the COG8 family. {ECO:0000305}.
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DR EMBL; AB041610; BAA95093.2; -; mRNA.
DR EMBL; AK049240; BAC33630.1; -; mRNA.
DR EMBL; AK049957; BAC34007.1; -; mRNA.
DR EMBL; AK083734; BAC39008.1; -; mRNA.
DR EMBL; AK145515; BAE26480.1; -; mRNA.
DR EMBL; AK159569; BAE35191.1; -; mRNA.
DR EMBL; CH466525; EDL11392.1; -; Genomic_DNA.
DR EMBL; CH466525; EDL11393.1; -; Genomic_DNA.
DR EMBL; BC094654; AAH94654.1; -; mRNA.
DR CCDS; CCDS22643.1; -.
DR RefSeq; NP_631975.3; NM_139229.4.
DR AlphaFoldDB; Q9JJA2; -.
DR SMR; Q9JJA2; -.
DR IntAct; Q9JJA2; 1.
DR STRING; 10090.ENSMUSP00000093173; -.
DR iPTMnet; Q9JJA2; -.
DR PhosphoSitePlus; Q9JJA2; -.
DR EPD; Q9JJA2; -.
DR MaxQB; Q9JJA2; -.
DR PaxDb; Q9JJA2; -.
DR PRIDE; Q9JJA2; -.
DR ProteomicsDB; 283344; -.
DR Ensembl; ENSMUST00000034391; ENSMUSP00000034391; ENSMUSG00000031916.
DR Ensembl; ENSMUST00000095517; ENSMUSP00000093173; ENSMUSG00000031916.
DR GeneID; 97484; -.
DR KEGG; mmu:97484; -.
DR UCSC; uc009ngy.2; mouse.
DR CTD; 84342; -.
DR MGI; MGI:2142885; Cog8.
DR VEuPathDB; HostDB:ENSMUSG00000031916; -.
DR eggNOG; KOG2069; Eukaryota.
DR GeneTree; ENSGT00390000015893; -.
DR HOGENOM; CLU_017968_0_0_1; -.
DR InParanoid; Q9JJA2; -.
DR OMA; QRCIHGV; -.
DR OrthoDB; 1531483at2759; -.
DR PhylomeDB; Q9JJA2; -.
DR TreeFam; TF315000; -.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR Reactome; R-MMU-6811438; Intra-Golgi traffic.
DR Reactome; R-MMU-6811440; Retrograde transport at the Trans-Golgi-Network.
DR BioGRID-ORCS; 97484; 10 hits in 73 CRISPR screens.
DR ChiTaRS; Cog8; mouse.
DR PRO; PR:Q9JJA2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9JJA2; protein.
DR Bgee; ENSMUSG00000031916; Expressed in ear vesicle and 211 other tissues.
DR ExpressionAtlas; Q9JJA2; baseline and differential.
DR Genevisible; Q9JJA2; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017119; C:Golgi transport complex; ISO:MGI.
DR GO; GO:0070085; P:glycosylation; ISO:MGI.
DR GO; GO:0007030; P:Golgi organization; ISO:MGI.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0000301; P:retrograde transport, vesicle recycling within Golgi; ISO:MGI.
DR InterPro; IPR007255; COG8.
DR InterPro; IPR016632; COG8_Metazoal_Plant.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR PANTHER; PTHR21311; PTHR21311; 1.
DR Pfam; PF04124; Dor1; 1.
DR PIRSF; PIRSF015415; COG8; 1.
DR SUPFAM; SSF74788; SSF74788; 1.
PE 1: Evidence at protein level;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..640
FT /note="Conserved oligomeric Golgi complex subunit 8"
FT /id="PRO_0000213522"
FT REGION 580..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 413
FT /note="G -> S (in Ref. 1; BAA95093)"
FT /evidence="ECO:0000305"
FT CONFLICT 627
FT /note="A -> G (in Ref. 1; BAA95093)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 640 AA; 71602 MW; E3BEB42870F32D44 CRC64;
MAAALPLQPS TTASATTTAT AVALGEVEDE GLLASLFRDR FPEAQWREKP DVGRYLRELS
GSGLDRLRRE PERLAEERAQ RLQQTRDLAF ANYKTFIRGA ECTERIHRLF GDVEASLGRL
LDRLPRFQQS CRNFVKEAEE ISSSRRMNTL TLNRHTEILE ILEIPQLMDT CVRNSYHEEA
LELAAYVRRL ERKYSSIPVI QGIVNEVRQS MQLMLSQLIQ QLRTNIQLPA CLRVIGYLRR
MDVFTEAELR VKFLQARDAW LRSILTAIPN DDPYFHITKT IEACRVHLFD IITQYRAIFS
DEDPLLPPAM GEYTVNEGAI FHGWVLQKIS QFLQVLETDL YRGIGGRLDS LLGQCMYFGL
SFSRVGADFR GQLAPVFQRV AISTFQKAVE EAVEKFQDEM TSYTLISTAA ILGSSNTPAT
VPATQPGTLQ PPMVLLDFPP LACFLNNILV AFNDLRLCCP VALAQDVTGT LENALTKVTK
TILAFHRAEE AVFSSGEHEI FVQFCTAFLE DLVPYLNRCL QVLFPPAQIA QTLGISPTQL
SKHGNLGHVN ISAIQEPLAF ILPKRETVFC LDEQELGPDL VAPAPELPAE QRSMEPVTEK
REPGEPLPQE PMEGEPLPAE PPSEGGAIGS VPCPQPGEQP
