ID   COIA_BACSU              Reviewed;         373 AA.
AC   O31604;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Competence protein CoiA;
GN   Name=coiA; Synonyms=yjbF; OrderedLocusNames=BSU11530;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RC   STRAIN=168;
RX   PubMed=17630974; DOI=10.1111/j.1365-2958.2007.05799.x;
RA   Kramer N., Hahn J., Dubnau D.;
RT   "Multiple interactions among the competence proteins of Bacillus
RT   subtilis.";
RL   Mol. Microbiol. 65:454-464(2007).
CC   -!- FUNCTION: Required for optimal transformation.
CC       {ECO:0000269|PubMed:17630974}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:17630974}.
CC       Note=Localizes at the cell poles of most competence-expressing cells
CC       (PubMed:17630974). During competence a number of proteins (at least
CC       CoiA, ComFA, ComGA, DprA, RecA and SsbB) are thought to colocalize at
CC       the cell pole (PubMed:17630974). {ECO:0000269|PubMed:17630974}.
CC   -!- DEVELOPMENTAL STAGE: Preferentially expressed in cells competent for
CC       DNA transformation; that is 5-15% of the population (PubMed:17630974).
CC       {ECO:0000269|PubMed:17630974}.
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DR   EMBL; AL009126; CAB13010.1; -; Genomic_DNA.
DR   PIR; F69843; F69843.
DR   RefSeq; NP_389035.1; NC_000964.3.
DR   RefSeq; WP_010886479.1; NC_000964.3.
DR   AlphaFoldDB; O31604; -.
DR   STRING; 224308.BSU11530; -.
DR   PaxDb; O31604; -.
DR   PRIDE; O31604; -.
DR   DNASU; 939370; -.
DR   EnsemblBacteria; CAB13010; CAB13010; BSU_11530.
DR   GeneID; 939370; -.
DR   KEGG; bsu:BSU11530; -.
DR   PATRIC; fig|224308.43.peg.1204; -.
DR   eggNOG; COG4469; Bacteria.
DR   OMA; TFTITKM; -.
DR   PhylomeDB; O31604; -.
DR   BioCyc; BSUB:BSU11530-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR   InterPro; IPR010330; CoiA-like.
DR   InterPro; IPR021176; Competence-induced_CoiA.
DR   Pfam; PF06054; CoiA; 1.
DR   PIRSF; PIRSF007487; Competence-induced_CoiA_bac; 1.
PE   2: Evidence at transcript level;
KW   Competence; Cytoplasm; Reference proteome.
FT   CHAIN           1..373
FT                   /note="Competence protein CoiA"
FT                   /id="PRO_0000387955"
SQ   SEQUENCE   373 AA;  43690 MW;  0AC8ED34F7E7E3AC CRC64;
     MFHLLGAQQN QKLKRRRFFC PVCGGELAVK LGLQKAPHFA HKQNKSCAID IEPESAYHLE
     GKRQLYVWLK TQRASPILEP YIRTINQRPD VMARIKEHML AVEYQCATIA PDVFQKRTEG
     FKQEGIIPQW IMGYSRLKRT ASSFYQLSTF HWQFINASPY RELICYCPER RSFLRLSHII
     PFYTNHSYSS VQTIPIHRAG AGDLFFTEPK PSIQYSGWTK AIHRFRHKPH RFNSKETNRL
     RLLFYEKRQT PFSFLPTEVF VPVRKGAVFK SPVFVWQGFL YLFMTDLGGK RAPIRFSAVL
     QQCKLHIHNK NIALRSECSE ECLSEAVKQY IDFLCKKGFL RETQKEVYVL NQPAGGIHSM
     QDLIERDRSC FIE