ID   COIL_XENLA              Reviewed;         536 AA.
AC   Q09003; Q6GQG7;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Coilin;
DE   AltName: Full=Sphere organelles protein SPH-1;
DE            Short=Sphere protein 1;
GN   Name=coil; Synonyms=sph1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Oocyte;
RX   PubMed=8349728; DOI=10.1083/jcb.122.4.767;
RA   Tuma R.S., Stolk J.A., Roth M.B.;
RT   "Identification and characterization of a sphere organelle protein.";
RL   J. Cell Biol. 122:767-773(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8349728}. Note=Sphere
CC       organelles.
CC   -!- TISSUE SPECIFICITY: Expressed in both oocytes and somatic cells.
CC       {ECO:0000269|PubMed:8349728}.
CC   -!- DOMAIN: The atypical Tudor domain at the C-terminus contains two large
CC       unstructured loops, and doesn't bind methylated residues.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the coilin family. {ECO:0000305}.
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DR   EMBL; Z23011; CAA80553.1; -; mRNA.
DR   EMBL; BC072777; AAH72777.1; -; mRNA.
DR   PIR; A40676; A40676.
DR   RefSeq; NP_001081591.1; NM_001088122.1.
DR   AlphaFoldDB; Q09003; -.
DR   BioGRID; 99276; 1.
DR   IntAct; Q09003; 1.
DR   PRIDE; Q09003; -.
DR   DNASU; 397940; -.
DR   GeneID; 397940; -.
DR   KEGG; xla:397940; -.
DR   CTD; 397940; -.
DR   Xenbase; XB-GENE-6252163; coil.L.
DR   OrthoDB; 1068620at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 397940; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0071601; C:sphere organelle; IDA:UniProtKB.
DR   InterPro; IPR024822; Coilin.
DR   InterPro; IPR031722; Coilin_N.
DR   PANTHER; PTHR15197; PTHR15197; 1.
DR   Pfam; PF15862; Coilin_N; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..536
FT                   /note="Coilin"
FT                   /id="PRO_0000072123"
FT   REPEAT          353..358
FT                   /note="1"
FT   REPEAT          380..385
FT                   /note="2"
FT   DOMAIN          425..523
FT                   /note="Tudor; atypical"
FT   REGION          96..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..385
FT                   /note="2 X 6 AA repeats of R-G-R-G-R-G"
FT   REGION          368..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..132
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..171
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..198
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..286
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        302..316
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..387
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        51
FT                   /note="D -> N (in Ref. 1; CAA80553)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        500
FT                   /note="G -> E (in Ref. 1; CAA80553)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   536 AA;  59521 MW;  E40D40959AD6CCBE CRC64;
     MAAPSPVRVK LLFDYPPPAI PESCMFWLLL DAKRCRVVTD LASIIRHKYM DGQGGGISLY
     VEDCLLPPGE SILVIRDNDS IRVKWDGAAI ERNQEAETCN DGAQNKSKKR HWKKSEDECD
     SGHKRKKQKS SSTQVDLKSG KDGGIRDKRK PSPPMECNAS DPEELRESGR KTHKGKRTKK
     KSEAPIENPP DKHSRKCPPQ ASNKALKLSW KRQTSSSDSS DTSSCSDQPT PTTQQKPQSS
     AKRQNQAATR ESVTHSVSPK AVNGISSTKN KKADAPISSS DMDTAVGGNE TLICPVPPED
     LSTHIQQHSQ SPTSDSAESI ELVIKKSNAS LSSLTDNRVA GVSDKLSPNV SGRGRGRGED
     FSWRGQRGRW FRGQGNNSNR GRGRGDSSNV FYKYNTEKEK QQQLEESATN VSIIIQNPQE
     TMKRDYSSLP LLAAAPQVGK LIAFKLLEVS ENYTPEVSEY KEGKILSFDP VTKQIEMEII
     SQQTMRKPGK FDVVYQSEDG EDIVEYAVPQ ESKVMLNWNT LIEPRLLMEK ESQVQC