ID   COL10_XENTR             Reviewed;         275 AA.
AC   Q5M8X6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Collectin-10;
DE   Flags: Precursor;
GN   Name=colec10;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Lectin that binds to various sugars: galactose > mannose =
CC       fucose > N-acetylglucosamine > N-acetylgalactosamine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the COLEC10/COLEC11 family. {ECO:0000305}.
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DR   EMBL; BC087791; AAH87791.1; -; mRNA.
DR   RefSeq; NP_001011227.1; NM_001011227.1.
DR   AlphaFoldDB; Q5M8X6; -.
DR   SMR; Q5M8X6; -.
DR   STRING; 8364.ENSXETP00000033873; -.
DR   PaxDb; Q5M8X6; -.
DR   DNASU; 496663; -.
DR   GeneID; 496663; -.
DR   KEGG; xtr:496663; -.
DR   CTD; 10584; -.
DR   Xenbase; XB-GENE-945586; colec10.
DR   eggNOG; KOG4297; Eukaryota.
DR   HOGENOM; CLU_049894_3_2_1; -.
DR   InParanoid; Q5M8X6; -.
DR   OrthoDB; 1105722at2759; -.
DR   PhylomeDB; Q5M8X6; -.
DR   Reactome; R-XTR-166662; Lectin pathway of complement activation.
DR   Reactome; R-XTR-166663; Initial triggering of complement.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q5M8X6; baseline.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005537; F:mannose binding; IEA:UniProtKB-KW.
DR   CDD; cd03591; CLECT_collectin_like; 1.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR018378; C-type_lectin_CS.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR033990; Collectin_CTLD.
DR   InterPro; IPR016187; CTDL_fold.
DR   Pfam; PF01391; Collagen; 2.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Collagen; Disulfide bond; Glycoprotein; Lectin; Mannose-binding;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..275
FT                   /note="Collectin-10"
FT                   /id="PRO_0000314236"
FT   DOMAIN          51..110
FT                   /note="Collagen-like"
FT   DOMAIN          153..269
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   REGION          39..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        30
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        174..268
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        246..260
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ   SEQUENCE   275 AA;  29731 MW;  0C7A567F505FE3DC CRC64;
     MKYGKLWPIG VSVLGVIALH VRVLSLEVEN SSAVDTCSTH TILPGPKGDD GEAGDTGVLG
     KLGKDGPKGQ KGNKGIIGDS GDLGLIGKIG PIGSKGDKGH KGLPGLPGGK GKSGSYCDCG
     RYRKVVGQLD VNVAHLKSSL KFVKNVIAGI RETDEKYYYI VREERNYRDA LTQCRIRGGT
     LAMPKDQATN SLIADYISKM GLFRVFIGIN DIEKEKQFVY ADNSPLQTYS SWKAGEPNDG
     SGYEDCVEML STGHWNDVDC SLTIYFVCEF LKKTK