ID   COL12_CAEEL             Reviewed;         316 AA.
AC   P20630;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Cuticle collagen 12;
DE   Flags: Precursor;
GN   Name=col-12; ORFNames=F15H10.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=1689778; DOI=10.1016/0022-2836(90)90360-x;
RA   Park Y.-S., Kramer J.M.;
RT   "Tandemly duplicated Caenorhabditis elegans collagen genes differ in their
RT   modes of splicing.";
RL   J. Mol. Biol. 211:395-406(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC       proteins. The cuticle functions both as an exoskeleton and as a barrier
CC       to protect the worm from its environment.
CC   -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC       by disulfide bonds and other types of covalent cross-links.
CC   -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
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DR   EMBL; X51622; CAA35954.1; -; Genomic_DNA.
DR   EMBL; Z73972; CAA98257.1; -; Genomic_DNA.
DR   PIR; S08169; S08169.
DR   RefSeq; NP_505678.1; NM_073277.3.
DR   AlphaFoldDB; P20630; -.
DR   SMR; P20630; -.
DR   STRING; 6239.F15H10.1.1; -.
DR   EPD; P20630; -.
DR   PaxDb; P20630; -.
DR   PeptideAtlas; P20630; -.
DR   PRIDE; P20630; -.
DR   EnsemblMetazoa; F15H10.1.1; F15H10.1.1; WBGene00000601.
DR   EnsemblMetazoa; F15H10.1.2; F15H10.1.2; WBGene00000601.
DR   EnsemblMetazoa; F15H10.1.3; F15H10.1.3; WBGene00000601.
DR   GeneID; 179453; -.
DR   KEGG; cel:CELE_F15H10.1; -.
DR   UCSC; F15H10.1.1; c. elegans.
DR   CTD; 179453; -.
DR   WormBase; F15H10.1; CE05638; WBGene00000601; col-12.
DR   eggNOG; KOG3544; Eukaryota.
DR   GeneTree; ENSGT00940000168256; -.
DR   HOGENOM; CLU_001074_4_2_1; -.
DR   InParanoid; P20630; -.
DR   OMA; FCIERST; -.
DR   OrthoDB; 1601318at2759; -.
DR   PhylomeDB; P20630; -.
DR   PRO; PR:P20630; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00000601; Expressed in adult organism and 3 other tissues.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   InterPro; IPR002486; Col_cuticle_N.
DR   InterPro; IPR008160; Collagen.
DR   Pfam; PF01484; Col_cuticle_N; 1.
DR   Pfam; PF01391; Collagen; 2.
DR   SMART; SM01088; Col_cuticle_N; 1.
PE   3: Inferred from homology;
KW   Collagen; Cuticle; Disulfide bond; Reference proteome; Repeat; Signal.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000255"
FT   CHAIN           37..316
FT                   /note="Cuticle collagen 12"
FT                   /id="PRO_0000006424"
FT   REGION          127..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..157
FT                   /note="Triple-helical region"
FT   REGION          176..202
FT                   /note="Triple-helical region"
FT   REGION          206..235
FT                   /note="Triple-helical region"
FT   REGION          240..266
FT                   /note="Triple-helical region"
FT   REGION          269..304
FT                   /note="Triple-helical region"
FT   COMPBIAS        241..255
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   316 AA;  30098 MW;  6CA81FF94706D42E CRC64;
     MTEDPKQIAQ ETESLRKVAF FGIAVSTIAT LTAIIAVPML YNYMQHVQSS LQSEVEFCQH
     RSNGLWDEYK RFQGVSGVEG RIKRDAYHRS LGVSGASRKA RRQSYGNDAA VGGFGGSSGG
     SCCSCGSGAA GPAGSPGQDG APGNDGAPGA PGNPGQDASE DQTAGPDSFC FDCPAGPPGP
     SGAPGQKGPS GAPGAPGQSG GAALPGPPGP AGPPGPAGQP GSNGNAGAPG APGQVVDVPG
     TPGPAGPPGS PGPAGAPGQP GQAGSSQPGG PGPQGDAGAP GAPGAPGQAG APGQDGESGS
     EGACDHCPPP RTAPGY