ID   COL14_CAEEL             Reviewed;         345 AA.
AC   P18834; Q18648;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2002, sequence version 2.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Cuticle collagen 14;
GN   Name=col-14; ORFNames=C46A5.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=2753356; DOI=10.1016/0378-1119(89)90173-x;
RA   Cox G.N., Fields C., Kramer J.M., Rosenzweig B., Hirsh D.;
RT   "Sequence comparisons of developmentally regulated collagen genes of
RT   Caenorhabditis elegans.";
RL   Gene 76:331-344(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC       proteins. The cuticle functions both as an exoskeleton and as a barrier
CC       to protect the worm from its environment.
CC   -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC       by disulfide bonds and other types of covalent cross-links.
CC   -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA27986.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; M25480; AAA27986.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; FO080769; CCD66588.1; -; Genomic_DNA.
DR   PIR; JS0169; JS0169.
DR   PIR; T29810; T29810.
DR   RefSeq; NP_001040923.1; NM_001047458.4.
DR   AlphaFoldDB; P18834; -.
DR   SMR; P18834; -.
DR   STRING; 6239.C46A5.3a; -.
DR   EPD; P18834; -.
DR   PaxDb; P18834; -.
DR   EnsemblMetazoa; C46A5.3a.1; C46A5.3a.1; WBGene00000603.
DR   GeneID; 177559; -.
DR   KEGG; cel:CELE_C46A5.3; -.
DR   CTD; 177559; -.
DR   WormBase; C46A5.3a; CE29723; WBGene00000603; col-14.
DR   eggNOG; KOG3544; Eukaryota.
DR   GeneTree; ENSGT00970000195927; -.
DR   InParanoid; P18834; -.
DR   OMA; FPPQCPC; -.
DR   OrthoDB; 1384044at2759; -.
DR   PRO; PR:P18834; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00000603; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; P18834; baseline and differential.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IBA:GO_Central.
DR   GO; GO:0042302; F:structural constituent of cuticle; NAS:UniProtKB.
DR   GO; GO:0040002; P:collagen and cuticulin-based cuticle development; NAS:UniProtKB.
DR   GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR   InterPro; IPR002486; Col_cuticle_N.
DR   InterPro; IPR008160; Collagen.
DR   Pfam; PF01484; Col_cuticle_N; 1.
DR   Pfam; PF01391; Collagen; 2.
DR   SMART; SM01088; Col_cuticle_N; 1.
PE   3: Inferred from homology;
KW   Collagen; Cuticle; Disulfide bond; Reference proteome; Repeat.
FT   CHAIN           1..345
FT                   /note="Cuticle collagen 14"
FT                   /id="PRO_0000127591"
FT   REGION          156..185
FT                   /note="Triple-helical region"
FT   REGION          161..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          207..263
FT                   /note="Triple-helical region"
FT   REGION          268..333
FT                   /note="Triple-helical region"
FT   COMPBIAS        178..222
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..258
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..289
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  35095 MW;  6AC2B149CAD4D6FE CRC64;
     MAKRARLRLI LLAKLVSLKM SDEKEKRSLR PVAFVAVVFS TVAITSCLIT FPLILHYIQT
     LESQVQLDLE FCQARARDMW KEMLDIETGG KKDSAKLANI VLNHRRLEKR DTLQDFWARR
     LHDQELRDQP VGYDNPSVGV ESFNSEGGGC CTCHRGPPGP AGDGGRDGAD GVDGTPGEIG
     PPGPPAPPGP DPHSLFPPQC PCEAPPGDGG PPGQPGPDGP PGAPGNAGED GKPGDQGPRG
     PPGIPGAPGQ PGRPGPPGEP GTYKTEVGPA GRAGAPGRPG PPGQPGPAGP PGENGKGGGQ
     GPSGLPGPPG QPGQNGAPGE VGQPGDNGAP GSCDHCPPAR LAPGY