COL40_CAEEL
ID COL40_CAEEL Reviewed; 302 AA.
AC P34804; O17374;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 3.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Cuticle collagen 40;
GN Name=col-40; ORFNames=T13B5.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=8299960; DOI=10.1016/0378-1119(93)90021-t;
RA Levy A.D., Kramer J.M.;
RT "Identification, sequence and expression patterns of the Caenorhabditis
RT elegans col-36 and col-40 collagen-encoding genes.";
RL Gene 137:281-285(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC proteins. The cuticle functions both as an exoskeleton and as a barrier
CC to protect the worm from its environment.
CC -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC by disulfide bonds and other types of covalent cross-links.
CC -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
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DR EMBL; L15419; AAA17726.1; -; Genomic_DNA.
DR EMBL; FO080410; CCD63495.1; -; Genomic_DNA.
DR PIR; T32458; T32458.
DR PIR; T37286; T37286.
DR RefSeq; NP_493913.2; NM_061512.2.
DR AlphaFoldDB; P34804; -.
DR SMR; P34804; -.
DR STRING; 6239.T13B5.4; -.
DR PaxDb; P34804; -.
DR EnsemblMetazoa; T13B5.4.1; T13B5.4.1; WBGene00000617.
DR GeneID; 173495; -.
DR KEGG; cel:CELE_T13B5.4; -.
DR UCSC; T13B5.4; c. elegans.
DR CTD; 173495; -.
DR WormBase; T13B5.4; CE45752; WBGene00000617; col-40.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00970000196518; -.
DR HOGENOM; CLU_001074_4_2_1; -.
DR InParanoid; P34804; -.
DR OMA; FHRFETV; -.
DR OrthoDB; 1601318at2759; -.
DR PRO; PR:P34804; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00000617; Expressed in adult organism and 1 other tissue.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR GO; GO:0042302; F:structural constituent of cuticle; NAS:UniProtKB.
DR GO; GO:0040002; P:collagen and cuticulin-based cuticle development; NAS:UniProtKB.
DR InterPro; IPR002486; Col_cuticle_N.
DR InterPro; IPR008160; Collagen.
DR Pfam; PF01484; Col_cuticle_N; 1.
DR Pfam; PF01391; Collagen; 2.
DR SMART; SM01088; Col_cuticle_N; 1.
PE 3: Inferred from homology;
KW Collagen; Cuticle; Disulfide bond; Reference proteome; Repeat.
FT CHAIN 1..302
FT /note="Cuticle collagen 40"
FT /id="PRO_0000127594"
FT REGION 79..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..143
FT /note="Triple-helical region"
FT REGION 119..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..185
FT /note="Triple-helical region"
FT REGION 189..221
FT /note="Triple-helical region"
FT REGION 226..252
FT /note="Triple-helical region"
FT REGION 255..290
FT /note="Triple-helical region"
FT COMPBIAS 163..179
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..206
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..244
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 2..18
FT /note="EEKQKIAEAESLKKLAF -> KLTEN (in Ref. 1; AAA17726)"
FT /evidence="ECO:0000305"
FT CONFLICT 30..31
FT /note="TA -> Q (in Ref. 1; AAA17726)"
FT /evidence="ECO:0000305"
FT CONFLICT 53
FT /note="V -> VQYFLKVHGVKKNYFQV (in Ref. 1; AAA17726)"
FT /evidence="ECO:0000305"
FT CONFLICT 56
FT /note="C -> S (in Ref. 1; AAA17726)"
FT /evidence="ECO:0000305"
FT CONFLICT 100
FT /note="G -> E (in Ref. 1; AAA17726)"
FT /evidence="ECO:0000305"
FT CONFLICT 167
FT /note="A -> P (in Ref. 1; AAA17726)"
FT /evidence="ECO:0000305"
FT CONFLICT 173
FT /note="A -> P (in Ref. 1; AAA17726)"
FT /evidence="ECO:0000305"
FT CONFLICT 179..181
FT /note="AGA -> EGAPGE (in Ref. 1; AAA17726)"
FT /evidence="ECO:0000305"
FT CONFLICT 188
FT /note="G -> R (in Ref. 1; AAA17726)"
FT /evidence="ECO:0000305"
FT CONFLICT 191..193
FT /note="EGP -> VGE (in Ref. 1; AAA17726)"
FT /evidence="ECO:0000305"
FT CONFLICT 202..203
FT /note="PA -> TS (in Ref. 1; AAA17726)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 302 AA; 28130 MW; 1C8E998B133D3160 CRC64;
MEEKQKIAEA ESLKKLAFFG ISVSTIATLT AIIAVPMLYN YMQHVQSSLQ NEVEFCKHRT
DGLWDEFHRF ETVKGVDSRI KRDTRSRRGG YAEGGAAAGG GGGGGGSCCS CGIGAAGPAG
APGKDGAPGE DGKAGNPGTA GSDAEAAAAP TASDFCFDCP PGPAGPAGGP GPAGPPGPAG
ADGNTPSGGG EGPAGPPGPP GPAGNPGTDG APGNPGAPGQ VTETPGTPGP AGAAGPPGPP
GPAGNPGSAG ASEPGPAGPA GDAGPDGAPG NAGAPGAPGE AGAPGSGGGC DHCPPPRTAP
GY
