ID   COL7_CAEEL              Reviewed;         316 AA.
AC   P18832; Q93210;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Cuticle collagen 7;
DE   Flags: Precursor;
GN   Name=col-7; ORFNames=C15A11.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-181.
RC   STRAIN=Bristol N2;
RX   PubMed=2753356; DOI=10.1016/0378-1119(89)90173-x;
RA   Cox G.N., Fields C., Kramer J.M., Rosenzweig B., Hirsh D.;
RT   "Sequence comparisons of developmentally regulated collagen genes of
RT   Caenorhabditis elegans.";
RL   Gene 76:331-344(1989).
CC   -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC       proteins. The cuticle functions both as an exoskeleton and as a barrier
CC       to protect the worm from its environment.
CC   -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC       by disulfide bonds and other types of covalent cross-links.
CC   -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
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DR   EMBL; Z79694; CAB01961.1; -; Genomic_DNA.
DR   EMBL; M25478; AAA27992.1; -; Genomic_DNA.
DR   PIR; T19291; T19291.
DR   RefSeq; NP_492090.1; NM_059689.5.
DR   AlphaFoldDB; P18832; -.
DR   SMR; P18832; -.
DR   STRING; 6239.C15A11.5; -.
DR   PaxDb; P18832; -.
DR   EnsemblMetazoa; C15A11.5.1; C15A11.5.1; WBGene00000596.
DR   GeneID; 172494; -.
DR   KEGG; cel:CELE_C15A11.5; -.
DR   UCSC; C15A11.5; c. elegans.
DR   CTD; 172494; -.
DR   WormBase; C15A11.5; CE08173; WBGene00000596; col-7.
DR   eggNOG; KOG3544; Eukaryota.
DR   GeneTree; ENSGT00970000196071; -.
DR   HOGENOM; CLU_001074_4_3_1; -.
DR   InParanoid; P18832; -.
DR   OMA; HRNVSRH; -.
DR   OrthoDB; 1490155at2759; -.
DR   PRO; PR:P18832; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00000596; Expressed in adult organism and 1 other tissue.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   InterPro; IPR002486; Col_cuticle_N.
DR   InterPro; IPR008160; Collagen.
DR   Pfam; PF01484; Col_cuticle_N; 1.
DR   Pfam; PF01391; Collagen; 1.
DR   SMART; SM01088; Col_cuticle_N; 1.
PE   3: Inferred from homology;
KW   Collagen; Cuticle; Disulfide bond; Reference proteome; Repeat; Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..316
FT                   /note="Cuticle collagen 7"
FT                   /id="PRO_0000006422"
FT   REGION          78..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..126
FT                   /note="Triple-helical region"
FT   REGION          139..198
FT                   /note="Triple-helical region"
FT   REGION          204..263
FT                   /note="Triple-helical region"
FT   REGION          281..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..157
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..243
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        48..60
FT                   /note="Missing (in Ref. 2; AAA27992)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        165
FT                   /note="G -> P (in Ref. 2; AAA27992)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   316 AA;  31240 MW;  7C311F63FCBD702B CRC64;
     MSSATFLSVM AGLSGIVVFG ALISVFHIYS DINSFVEDSH RELGEFKGFA NDAWNSMINQ
     DDSVRMARSV FGRRRQKKQS QCNCGQQASN CPAGPPGPPG ASGDKGHDGQ PGQAGKPGQP
     GVAGPSHHQK QECIKCPQGL PGPAGVPGQP GPKGPNGNPG APAQGGGQGP PGPPGPAGSA
     GSPGQAGAPG NPGSPGKSGQ RGRGLPGPSG APGPQGPPGA PGQPGSGNAP GPAGPPGPAG
     PNGQPGHPGQ DGQPGAPGND GTPGSDAAYC PCPTRSSVLR HRNVNRHRAA ASKKRVVAKK
     RVAKKRVVAA RRHVQA