ID   COL8_CAEEL              Reviewed;         282 AA.
AC   P18833; Q19359;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Cuticle collagen 8;
DE   Flags: Precursor;
GN   Name=col-8; ORFNames=F11H8.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=2753356; DOI=10.1016/0378-1119(89)90173-x;
RA   Cox G.N., Fields C., Kramer J.M., Rosenzweig B., Hirsh D.;
RT   "Sequence comparisons of developmentally regulated collagen genes of
RT   Caenorhabditis elegans.";
RL   Gene 76:331-344(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Nematode cuticles are composed largely of collagen-like
CC       proteins. The cuticle functions both as an exoskeleton and as a barrier
CC       to protect the worm from its environment.
CC   -!- SUBUNIT: Collagen polypeptide chains are complexed within the cuticle
CC       by disulfide bonds and other types of covalent cross-links.
CC   -!- SIMILARITY: Belongs to the cuticular collagen family. {ECO:0000305}.
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DR   EMBL; M25479; AAA27993.1; -; Genomic_DNA.
DR   EMBL; FO080391; CCD63397.1; -; Genomic_DNA.
DR   PIR; JS0168; JS0168.
DR   PIR; T16036; T16036.
DR   RefSeq; NP_498533.2; NM_066132.6.
DR   AlphaFoldDB; P18833; -.
DR   BioGRID; 41193; 1.
DR   STRING; 6239.F11H8.3; -.
DR   EPD; P18833; -.
DR   PaxDb; P18833; -.
DR   PeptideAtlas; P18833; -.
DR   EnsemblMetazoa; F11H8.3.1; F11H8.3.1; WBGene00000597.
DR   GeneID; 175981; -.
DR   UCSC; F11H8.3; c. elegans.
DR   CTD; 175981; -.
DR   WormBase; F11H8.3; CE51260; WBGene00000597; col-8.
DR   eggNOG; KOG3544; Eukaryota.
DR   GeneTree; ENSGT00970000196588; -.
DR   HOGENOM; CLU_001074_4_3_1; -.
DR   InParanoid; P18833; -.
DR   OMA; DEMFEFR; -.
DR   OrthoDB; 1766544at2759; -.
DR   PRO; PR:P18833; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000597; Expressed in adult organism and 2 other tissues.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0042302; F:structural constituent of cuticle; IEA:UniProtKB-KW.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   InterPro; IPR002486; Col_cuticle_N.
DR   Pfam; PF01484; Col_cuticle_N; 1.
DR   SMART; SM01088; Col_cuticle_N; 1.
PE   3: Inferred from homology;
KW   Collagen; Cuticle; Disulfide bond; Reference proteome; Repeat; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..282
FT                   /note="Cuticle collagen 8"
FT                   /id="PRO_0000006423"
FT   REGION          86..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          95..124
FT                   /note="Triple-helical region"
FT   REGION          141..269
FT                   /note="Triple-helical region"
FT   CONFLICT        43
FT                   /note="R -> T (in Ref. 1; AAA27993)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        142
FT                   /note="R -> C (in Ref. 1; AAA27993)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        190
FT                   /note="R -> C (in Ref. 1; AAA27993)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   282 AA;  28150 MW;  9A49862A5D88FEEC CRC64;
     MLVCVFVALY TMMGLLTDIK QLQSDFDDEM FEFRAITKDT WQRIVTKHTY PGGVDEETIE
     SHPPTFETLF GTRKARQAYP EQCNCGPKSE GCPAGPPGPP GEGGQSGEPG HDGDDGKPGA
     PGVIVAITHD IPGGCIKCPP GRPGPRGPSG LVGPAGPAGD QGRHGPPGPT GGQGGPGEQG
     DAGRPGAAGR PGPPGPRGEP GTEYRPGQAG RAGPPGPRGP PGPEGNPGGA GEDGNQGPVG
     HPGVPGRPGI PGKSGTCGEH GGPGEPGPDA GYCPCPGRSY KA