ID   COLA1_XENLA             Reviewed;         957 AA.
AC   Q641F3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Collagen alpha-1(XXI) chain;
DE   Flags: Precursor;
GN   Name=col21a1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the fibril-associated collagens with interrupted
CC       helices (FACIT) family. {ECO:0000305}.
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DR   EMBL; BC082384; AAH82384.1; -; mRNA.
DR   RefSeq; NP_001087858.1; NM_001094389.1.
DR   AlphaFoldDB; Q641F3; -.
DR   SMR; Q641F3; -.
DR   DNASU; 447719; -.
DR   GeneID; 447719; -.
DR   KEGG; xla:447719; -.
DR   CTD; 447719; -.
DR   Xenbase; XB-GENE-952330; col21a1.L.
DR   OMA; CMNGPSD; -.
DR   OrthoDB; 1295141at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 447719; Expressed in pancreas and 5 other tissues.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF01391; Collagen; 7.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00210; TSPN; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   2: Evidence at transcript level;
KW   Collagen; Cytoplasm; Extracellular matrix; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..957
FT                   /note="Collagen alpha-1(XXI) chain"
FT                   /id="PRO_0000317614"
FT   DOMAIN          37..211
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   DOMAIN          230..412
FT                   /note="Laminin G-like"
FT   DOMAIN          448..501
FT                   /note="Collagen-like 1"
FT   DOMAIN          502..543
FT                   /note="Collagen-like 2"
FT   DOMAIN          544..591
FT                   /note="Collagen-like 3"
FT   DOMAIN          592..642
FT                   /note="Collagen-like 4"
FT   DOMAIN          643..684
FT                   /note="Collagen-like 5"
FT   DOMAIN          685..741
FT                   /note="Collagen-like 6"
FT   DOMAIN          742..786
FT                   /note="Collagen-like 7"
FT   DOMAIN          825..882
FT                   /note="Collagen-like 8"
FT   REGION          441..788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          820..935
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        536..554
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        729..748
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   957 AA;  99759 MW;  765F4A9AA5BBDC0D CRC64;
     MPGIIYILCS ILLIESQYYV ASENAEIRSS CRTAPNDLVF ILDGSWSVGP ENFEILKKWV
     VNITSNFNIG PKFTQVGVVQ YSDYPILEIP LGSYESIDDL SRRTQSIQYL GGNTQTGNAI
     QFAIDNLFAR SLRPLTKIAI VLTDGKSQDD VKHIAEEARK NKITLFAIGV GSEIEESELR
     AIANKPSSTY VFYVEDYIAI SRIREIMKQK LCEESVCPTR IPVAARDEKG FDILLGLGIN
     KKKAKRVEGS RPRNKAYEIT SQIDLTEFTG NVFPEGLPPS YVFISTLRFK IKKKWDLWRI
     LALDGTIQTA VSLNGEEKTL SFTTTNEENG TQAITFTTPG VKKLFDEEWH QIRLLVTEED
     ITLYVDDQEI ETRKLLPVIG IYISGQTQIG KYPAREESVQ FTLQKLRIYC DPEQNKRETA
     CEIPGTNGEC LNGPSDVGGT PAPCICPPGE KGDPGPKGDS GQPGNPGSPG QPGPDGKHGF
     QGTSGSPGIP GSPGVQGPRG FAGLKGNTGQ DGEKGDRGMP GFPGLHGQPG IKGEMGPKGD
     KGDIGIDGKK GTKGDKGGNG ATGKPGRHGE PGSYGKDGIP GYPGQKGEEG KPGPPGMEGL
     RGLPGIPGIP GNDGANGLKG ETGLSGEPGA RGPTGTPGIS GPEGISGPQG PVGPKGNKGE
     TGPPGKASPA GMKGEKGEMG IPGQQGYTGI PGLMGPKGDK GNLGERGMQG HKGEHGSSGM
     PGLKGEHGVT GSKGEKGEIG EHGHRGITGP RGEPGNMGLI GAPGPRGMSG ERGTQGLPGP
     KGQQGKEQSE AFIRQICLDV LKAQLPSLIQ NDIRQNCNQC KTQEGSPGLP GPPGPVGPEG
     TRGHPGLPGR NGFSGLVGQP GLPGIPGTKG LPGKPGAKGN KGDIEPGPQG SPGVPGPAGL
     PGVGKDGRTG PLGPPGREGD RGPPGTQGPP GDAGICDPSL CYGAVMRRDP FRKGPNY