COLB_DICDI
ID COLB_DICDI Reviewed; 3763 AA.
AC Q8T2A1; Q554S2;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Colossin-B;
DE Flags: Precursor;
GN Name=colB; ORFNames=DDB_G0274221;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the serine-aspartate repeat-containing protein
CC (SDr) family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70003.1; -; Genomic_DNA.
DR RefSeq; XP_644251.1; XM_639159.1.
DR STRING; 44689.DDB0237871; -.
DR PaxDb; Q8T2A1; -.
DR EnsemblProtists; EAL70003; EAL70003; DDB_G0274221.
DR GeneID; 8619679; -.
DR KEGG; ddi:DDB_G0274221; -.
DR dictyBase; DDB_G0274221; colB.
DR eggNOG; KOG1217; Eukaryota.
DR HOGENOM; CLU_224371_0_0_1; -.
DR InParanoid; Q8T2A1; -.
DR OMA; SCANLNG; -.
DR PhylomeDB; Q8T2A1; -.
DR PRO; PR:Q8T2A1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031160; C:spore wall; IEA:UniProt.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProt.
DR Gene3D; 2.60.40.10; -; 15.
DR InterPro; IPR003645; Fol_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR033764; Sdr_B.
DR Pfam; PF17210; SdrD_B; 15.
DR SMART; SM00274; FOLN; 3.
PE 3: Inferred from homology;
KW Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..3763
FT /note="Colossin-B"
FT /id="PRO_0000363153"
FT DOMAIN 619..643
FT /note="Follistatin-like 1"
FT DOMAIN 701..724
FT /note="Follistatin-like 2"
FT DOMAIN 729..752
FT /note="Follistatin-like 3"
FT DOMAIN 1159..1227
FT /note="CNA-B 1"
FT DOMAIN 1304..1373
FT /note="CNA-B 2"
FT DOMAIN 1437..1515
FT /note="CNA-B 3"
FT DOMAIN 1582..1648
FT /note="CNA-B 4"
FT DOMAIN 1731..1809
FT /note="CNA-B 5"
FT DOMAIN 2015..2083
FT /note="CNA-B 6"
FT DOMAIN 2143..2197
FT /note="CNA-B 7"
FT DOMAIN 2292..2345
FT /note="CNA-B 8"
FT DOMAIN 2453..2477
FT /note="CNA-B 9"
FT DOMAIN 2713..2766
FT /note="CNA-B 10"
FT DOMAIN 2984..3061
FT /note="CNA-B 11"
FT DOMAIN 3128..3201
FT /note="CNA-B 12"
FT DOMAIN 3664..3733
FT /note="CNA-B 13"
FT REGION 792..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1883..1955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..830
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1884..1951
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 258
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 284
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 652
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 672
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 845
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 991
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1054
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1229
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1247
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1381
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1769
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1815
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2243
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2294
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2378
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2493
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2496
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2516
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2572
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2601
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2624
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2668
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2698
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2714
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2781
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2787
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2800
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2838
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2858
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3083
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3372
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3390
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3459
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3466
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3557
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3666
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3676
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3681
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 3763 AA; 416946 MW; 83E8D27C0164EDF6 CRC64;
MKGSIFLLFI FQIFKFSSSY SHYPHKNQFS FYSPTSLSFT SSNFSSGSGS GSGGASGSGG
GGNIGNKYNN ENNKINEEII ISCIYDDYLN FQYQDLSKIN GILINGFNKN STSDIFVKNV
NSQYYDQSDS SNNFHYFDQE NNNLSPQSQL NKECPFNLKN PIPTFSNSRY SIKIDKSFDV
SDEITLVSKN NFLNSNSISK LKFKVYIPNK ITNKIKIQLI NSLTGNNGPK IPLLNTIENN
YLKPFPCHQW LDAFILFNET NYYNNNNNNN YPIFYNGLKI TSSNRSLDNT WIDEVYIDEI
KLISNNNKHN SNKNDRKRNI DQTNEIYDKI NINNNNYNIR KLFSILDDNN NNNNNNNNNN
NNNNNNEIIN SYNTINSRAD IALGGNSDDQ SDISYSIICN KHMNELNNEI KWRFEEGSSS
SLVETANGNL ILEGSIHSIS KHQADYNFNC KTNWKIRIEF SPIIDDYQYN GRMELASFAY
TKNGGPIDTL YWKYYKFVNG YLSGLDCNQG KLIQINNNNN HNENNNGILQ IGIGANNKNG
RFGLSVYGLQ LSIDNDNTFN INVDLNNQNN HLSNNNNKNN NNNNNNEVLE CNCPIGFICL
NDGTCKLNFQ NDVDEEYIDC STLQCPSGYE CKLDKNSKTR GCIEQIGPQN LNQTNKCLGN
LKCPDGFGCW HNSTDNTLNC KQYNNHKFDT NVIDSEKHRH HCRNVDCPKS HYCKIQRNGL
PRCFPKVNPC EFVSCDCNLE CRVTSCGDAK CFAPEECCEG KACMDTRNYR CVKINGVDEC
VRIPPLKPLP PPPIFYETPS PTSAPPTETP SPTDTPTDKP TIPPTPTPTP SKEITDCSQV
ICQVNYTCFD IQKGVGPFTP VCIPINYCDE YTTRFDLQGY VWLDDNENGY RDVNENGVET
EPIGVEGIFC NLVFSTDHSP ARNHYGDIIP VSVTNLDGFF SFNDVVPGSY VIDFYNIKGY
HWTLPFNRYF KNSNWVNSDG TSLPFELPQY NVSNPNFIIS PQSNLISKSI TLPQPIFSTN
AIVTVNNDGF DELGSSGSGS SGNSGSSGSG GSSNDSTESQ WSSESESSAS LITPSNICQT
HFTVSNILAG LIVGPQPTPS TDIPTTTTTT TSTSTTGPIE PTSTPTPIVD VIDYYGIGKQ
VFIDFNNNGI FDSGIDRPVS GVEITLIQKG FRAYNHKGDK VPTIKTDTNG FYFFDALAPG
VYRVSLNNLP PHGYTNSLLN KYPIDTSSNT SAQFIVYYRV KDNIKYNASD YPLASSNIKP
KLAQYINSYV DFALVPINPP IAVGDTVYFD SNQNGKQDPF EKGIKGIQVT LKDLKNGYEY
KTITDDNGKY LFDQMIESDN YQLQFSVPNG FQVVDHPNSI KNGVYTMDTF QLSSSTTPPT
NASLTKGVVG NKKVNSAYFD DSKDVPLYFE NSYAIGHQAF IDTNLDGLYK NDLDKPLPGV
EVTLVNAASP STPITNILGQ IVRTVITDAK GFYQFDFLKP NNYIVQFKPP TGFKVTKPPP
NTATYPELGS LIDTKSFKTP SLDIVTLSKP KNIEYIRLNV QASNIFESVN AGFYIPPTFS
IGHRVWYDTN ADGIMDPTEE GVPGIVVSLY TDKSEPAYDI NDNLIIPTIT DSKGFYLLTK
IPTGNYFISF SNLPKGYTWT KQNVLTLDSV GYDSRPNVFT GYTSLFEMST TSQLVRTTVP
SDNSPDFYIN PIENAGIIKG NRGLVIKYAV GRYIFYDDNR NGILDDYENG VGGVIVQIFT
SAGKPALDFN GKVIPPAVTD STGRYIIDNL SQGDYIIQFS NIPNGYNFEN LPPPYPNYLN
GRIGTFTLSP SSSINTTNVI KKFNPPKPNG GKKVSFSHSI NQKSRKLLND GIIGQDTSVD
LSNVIAGGST VDGVDIPNVI AGGSTVDGGT SVNGGTGSTS TTTVSSSPSS SSDIGSSSDI
SSEVSSSLSS SPSSSEQPSE QSSSSSEQPP EDSMEEYPVH YYEPVFETTP GSYPLDSIKA
ERTDLTRNAA IVRAAPYAFG QKVFFIDNNG NEVGVPDVTV TLVNSNGFPV TSINGVNMVP
TKTDSKGSYR FNLLRAGSYH VEFSNIPIGF SFFDPLSGKI DFNLVNTDPN VRGAIPADKV
PKATYYDQHV NLQLNPPFIF AIGTRVWNDT NKNGLYEIAE PVFPNITVRL FDQNLQPVLD
NFNIQVEPTV TNALGQYYFD NLHSGSYIVK FEVPTRYYFA PQLKSIENSN GVGVNSKPNS
QGYTSVISLS PDSLVEAPPS DFNFTIRSLV GNFHIDAGLI YDENYVKSYA VGRYVFYDLN
DNGIMDSGEM GVPNVTVEIF NPTGQQVYNI NELLIGSTTT DSNGYYLFDE IQPGSYIIKF
SNIPNDLMFG NKTKPNSNTG LTEPFLLFPK EPAIRLVNST TDVGVKAQAV DFTENAGLIK
KVTFAIGHYV WYDINSNGLQ DYPNEPPAYG VPLRLLKCNL IGITYDTCFT VINTTTTDQN
GLYYFDNLSP GLYKLLFMNQ QGIFETTTPF AGNGTNDSKA IDEAITGIRL SIYTKNVTKT
DSNLDPMIKA PFIDRTLNVG ILKPPMFSIG HKVWYDTNKN GKIDLKEQPA PNVTIYLKRA
KEVNFEYSFD LYGKPMIAKT NETGDYWINN IPPGLYIAKF FPPNDTRFTI QMNDNSANVF
GSSYAIYLFY KVPGIHPYNL KVDIGAVNAS YVYSKVNAGL LKGLVDIRLY AVSGYVYNDT
NSNGIRDPGE NGVNGTIVTL LDINGNTMVD ADSYPINSYT TGPDGYYKFD DFSFGKYIIT
FSGVPDLIYQ FYKPDDQQHL NHSTLSNITI WSPDNPMVVN ATLSDHVNAQ YILREQNKGI
IRVITYAIGG KVIPDFKNTT YKDSGYAGGA VIVQLYRNNS IATDLRGNPI PSVLTNVLTG
EYLFDNVPIL EGYQVMFSSP PPGWIFEKYR ITQTPFIQLD LLPSFNLPKS NPKLIDKKLY
PNIFATYGVL DQDTIISPTL FGIGKNTFID VENSGLESIP LIPLGGVVVT LYNSVFERVF
DAFGNLVKEK TTGEDGEYSF EDLYSGQYIV HFGLVEGYSF TQQYAGTDPE IDSNASPVDG
YSEIIQLDSM NNELILIPLE SRNNTLFCDP TIDGGYVSLS PQGFISGMTY IDYNADGVFT
PNSRDKPYPN ITVSIYTGDD SRLVATAQTD KKGFYSFSHL FISTQYQVVF SGIPQGYYTS
FQADTVQFPI ATKTGVNLGI IKPLEYCQDD IKIITTCFVR GDSNDDLPAV VQFPYTAYSD
LNGDNGQKVD LVTMSETKTV YGLGYDRKEN TIYLSPYKKQ FSSLNSKTSS TIFKKSLSTG
ALSAYVNLAT VLGFDFLAPN GKVYGDSQTY RVLFGDLDII GDYIWVTNLY RNIVVKIPLR
QTPTRENIKL VNITHNCGPD PFRIFGLGYN GSNVFVGGVC EGSVSKDIRN VIGVIKVISS
DETSFSDVLT IPMNYPRGRL QTRIMFLNDM TPIFSSVQNS TWQVWNDTVG SFKPQPQITD
ITFIGDGGNM VISMKDREAD SQSVTPAGDI LMACKDSNGV YQLESAGVCG GLIGTNPISI
GTMIEQGPGG GEFFDDNFSD RDWQHDETTW GSSYYLPGSG EVIGGAYDLL STNEAIVKHW
SVYNGRVLYG FILIHGAGLD YVFNKVNGLG DMDANCRLPN TYIGNYVWYD LNKNGLQDPN
EKGMANITVQ LFSAANSTFI NSTLTDSSGN YNFQVISEFK YRVHFVAPKG FTYSPIVTVS
SDPNDKRDLE KINSLPDSKG DAYFFANGNG ENTQDIDCGF IRI
