位置:首页 > 蛋白库 > COLC1_HUMAN
COLC1_HUMAN
ID   COLC1_HUMAN             Reviewed;         124 AA.
AC   Q6ZS62;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Colorectal cancer-associated protein 1;
GN   Name=COLCA1; Synonyms=C11orf92;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=24154973; DOI=10.1002/ijc.28557;
RA   Peltekova V.D., Lemire M., Qazi A.M., Zaidi S.H., Trinh Q.M., Bielecki R.,
RA   Rogers M., Hodgson L., Wang M., D'Souza D.J., Zandi S., Chong T.,
RA   Kwan J.Y., Kozak K., De Borja R., Timms L., Rangrej J., Volar M.,
RA   Chan-Seng-Yue M., Beck T., Ash C., Lee S., Wang J., Boutros P.C.,
RA   Stein L.D., Dick J.E., Gryfe R., McPherson J.D., Zanke B.W., Pollett A.,
RA   Gallinger S., Hudson T.J.;
RT   "Identification of genes expressed by immune cells of the colon that are
RT   regulated by colorectal cancer-associated variants.";
RL   Int. J. Cancer 134:2330-2341(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24154973}; Single-
CC       pass membrane protein {ECO:0000269|PubMed:24154973}. Note=Co-localizes
CC       with crystalloid granules of eosinophils and granular organelles of
CC       mast cells, neutrophils, macrophages and dendritic cells.
CC   -!- TISSUE SPECIFICITY: Expressed in gastrointestinal and immune tissue, as
CC       well as prostate, testis and ovary. Expressed in lamina propria and
CC       eosinophils but not in epithelial cells. Expression is greater in
CC       benign adjacent tissues than in colon tumors.
CC       {ECO:0000269|PubMed:24154973}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK127703; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AP002448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001289573.1; NM_001302644.1.
DR   RefSeq; NP_001289574.1; NM_001302645.1.
DR   RefSeq; NP_001289575.1; NM_001302646.1.
DR   RefSeq; NP_001289576.1; NM_001302647.1.
DR   RefSeq; NP_001289577.1; NM_001302648.1.
DR   RefSeq; NP_997312.1; NM_207429.3.
DR   AlphaFoldDB; Q6ZS62; -.
DR   BioMuta; HGNC:33789; -.
DR   DMDM; 74711342; -.
DR   PaxDb; Q6ZS62; -.
DR   PRIDE; Q6ZS62; -.
DR   DNASU; 399948; -.
DR   GeneID; 399948; -.
DR   CTD; 399948; -.
DR   DisGeNET; 399948; -.
DR   GeneCards; COLCA1; -.
DR   HGNC; HGNC:33789; COLCA1.
DR   MIM; 615693; gene.
DR   neXtProt; NX_Q6ZS62; -.
DR   InParanoid; Q6ZS62; -.
DR   OrthoDB; 1566774at2759; -.
DR   PhylomeDB; Q6ZS62; -.
DR   TreeFam; TF354066; -.
DR   PathwayCommons; Q6ZS62; -.
DR   BioGRID-ORCS; 399948; 3 hits in 182 CRISPR screens.
DR   ChiTaRS; COLCA1; human.
DR   GenomeRNAi; 399948; -.
DR   Pharos; Q6ZS62; Tdark.
DR   PRO; PR:Q6ZS62; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q6ZS62; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IDA:UniProtKB.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..124
FT                   /note="Colorectal cancer-associated protein 1"
FT                   /id="PRO_0000340692"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   124 AA;  13401 MW;  2175E678FD208735 CRC64;
     MESCSVAQAG VLTSPFMWRW TGMAGALSAL DNTIEDDADD QLPCGEGRPG WVRGELLGSQ
     GVCKDSKDLF VPTSSSLYGC FCVGLVSGMA ISVLLLASDF RKLDFSRPEP CFEKEASLWF
     VAQH
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024