COLC1_HUMAN
ID COLC1_HUMAN Reviewed; 124 AA.
AC Q6ZS62;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Colorectal cancer-associated protein 1;
GN Name=COLCA1; Synonyms=C11orf92;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=24154973; DOI=10.1002/ijc.28557;
RA Peltekova V.D., Lemire M., Qazi A.M., Zaidi S.H., Trinh Q.M., Bielecki R.,
RA Rogers M., Hodgson L., Wang M., D'Souza D.J., Zandi S., Chong T.,
RA Kwan J.Y., Kozak K., De Borja R., Timms L., Rangrej J., Volar M.,
RA Chan-Seng-Yue M., Beck T., Ash C., Lee S., Wang J., Boutros P.C.,
RA Stein L.D., Dick J.E., Gryfe R., McPherson J.D., Zanke B.W., Pollett A.,
RA Gallinger S., Hudson T.J.;
RT "Identification of genes expressed by immune cells of the colon that are
RT regulated by colorectal cancer-associated variants.";
RL Int. J. Cancer 134:2330-2341(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24154973}; Single-
CC pass membrane protein {ECO:0000269|PubMed:24154973}. Note=Co-localizes
CC with crystalloid granules of eosinophils and granular organelles of
CC mast cells, neutrophils, macrophages and dendritic cells.
CC -!- TISSUE SPECIFICITY: Expressed in gastrointestinal and immune tissue, as
CC well as prostate, testis and ovary. Expressed in lamina propria and
CC eosinophils but not in epithelial cells. Expression is greater in
CC benign adjacent tissues than in colon tumors.
CC {ECO:0000269|PubMed:24154973}.
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DR EMBL; AK127703; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AP002448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001289573.1; NM_001302644.1.
DR RefSeq; NP_001289574.1; NM_001302645.1.
DR RefSeq; NP_001289575.1; NM_001302646.1.
DR RefSeq; NP_001289576.1; NM_001302647.1.
DR RefSeq; NP_001289577.1; NM_001302648.1.
DR RefSeq; NP_997312.1; NM_207429.3.
DR AlphaFoldDB; Q6ZS62; -.
DR BioMuta; HGNC:33789; -.
DR DMDM; 74711342; -.
DR PaxDb; Q6ZS62; -.
DR PRIDE; Q6ZS62; -.
DR DNASU; 399948; -.
DR GeneID; 399948; -.
DR CTD; 399948; -.
DR DisGeNET; 399948; -.
DR GeneCards; COLCA1; -.
DR HGNC; HGNC:33789; COLCA1.
DR MIM; 615693; gene.
DR neXtProt; NX_Q6ZS62; -.
DR InParanoid; Q6ZS62; -.
DR OrthoDB; 1566774at2759; -.
DR PhylomeDB; Q6ZS62; -.
DR TreeFam; TF354066; -.
DR PathwayCommons; Q6ZS62; -.
DR BioGRID-ORCS; 399948; 3 hits in 182 CRISPR screens.
DR ChiTaRS; COLCA1; human.
DR GenomeRNAi; 399948; -.
DR Pharos; Q6ZS62; Tdark.
DR PRO; PR:Q6ZS62; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6ZS62; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IDA:UniProtKB.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..124
FT /note="Colorectal cancer-associated protein 1"
FT /id="PRO_0000340692"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 124 AA; 13401 MW; 2175E678FD208735 CRC64;
MESCSVAQAG VLTSPFMWRW TGMAGALSAL DNTIEDDADD QLPCGEGRPG WVRGELLGSQ
GVCKDSKDLF VPTSSSLYGC FCVGLVSGMA ISVLLLASDF RKLDFSRPEP CFEKEASLWF
VAQH