ID   COLC_DICDI              Reviewed;         981 AA.
AC   Q54TT6;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Colossin-C;
DE   Flags: Precursor;
GN   Name=colC; ORFNames=DDB_G0281507;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the serine-aspartate repeat-containing protein
CC       (SDr) family. {ECO:0000305}.
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DR   EMBL; AAFI02000041; EAL66735.1; -; Genomic_DNA.
DR   RefSeq; XP_640725.1; XM_635633.1.
DR   AlphaFoldDB; Q54TT6; -.
DR   STRING; 44689.DDB0237870; -.
DR   PaxDb; Q54TT6; -.
DR   EnsemblProtists; EAL66735; EAL66735; DDB_G0281507.
DR   GeneID; 8623114; -.
DR   KEGG; ddi:DDB_G0281507; -.
DR   dictyBase; DDB_G0281507; colC.
DR   eggNOG; ENOG502RSUB; Eukaryota.
DR   HOGENOM; CLU_303564_0_0_1; -.
DR   InParanoid; Q54TT6; -.
DR   OMA; HYFDFRE; -.
DR   PhylomeDB; Q54TT6; -.
DR   PRO; PR:Q54TT6; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR033764; Sdr_B.
DR   Pfam; PF17210; SdrD_B; 3.
PE   3: Inferred from homology;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..981
FT                   /note="Colossin-C"
FT                   /id="PRO_0000388251"
FT   REGION          172..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..195
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        63
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        222
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        591
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        811
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   981 AA;  106068 MW;  BA74CE5443D083E2 CRC64;
     MKILYSLLLI SSIILNTVLN ISSQVYDQRI LALKGKCYLD SNKNALYDEG EPGFGNVEIS
     LGNATDYKGN KYPIRYSSAD GTFIYDGLTQ RTTYEFTFTN PKDYYFETYE KTLACPPGVP
     CIRPTVSADN LAADLLVANT FAYNIPLIKQ VGVSSGSSIL TVRISVDLGY VEQTQPPTQP
     PTQPPTQPPT PPPFTGSAVA GLLFTDINGN GIFDGRDVWT SNVSVGLYNF NDKTRALDVN
     GNVISSITTD ANGRYAFENV ANGVYCLWME GTKYFNPGCV GRIEINSATM PKSVASDGVQ
     SPTILRAGSF SLFLTGNSGY GGYAYNDIDL NGYLSSRDQG IAGIIVKIYL PVYNFLFGTV
     TTDSNGRWSF SGLQPGFPVR IEFVIPNDFT STGANLVNFV TVGQSIDLSI GLIPKSLTGV
     NAGPSNPKSF VTTCFVKGSY NGKYKDEPTV VEINKDAQGK AYAQQSADYM KVLASHKDTG
     SVHGVAFNPD NGDKFVSSYH KTNSDFGPSG SCAIYKLSSG IITTHVNFND VFGKSYCGGY
     AHYFDFREIS TAGPLVGKAS LGQMTYYNKK LYVTNLGKNE ILVVPIYQNP NATNVERIPV
     ANPGCSSGDD WHIFPVTVFQ GELFTGGVCS GEKGSRLSTY ILKYNPNSKS FSTVLFYTLG
     YARGCRYLDS FGSCVSSVWQ KWSNNDSPQA LLSTIIFDVS GHLIMAYKDR SGDISAVVSA
     PELLIACLGT DGLFYLESGG KCGSLVGAGV DQKSLTGLRY GPGNGNFFDN HKTGLHDYTN
     AFGATKGGRD IIVTTGFDYY EAFEGSIRWY NATSGKQLKG YSLYITSSNG RTPSPTFGKQ
     NGLGDITSVY DSSLPQYRVG RVWLDINGNG IQDAGEPGIS GITVFLIYGQ QSTPTSQTVS
     DSNGYFKFEV DFSSNYYCVI PVAFFQAGSS ITMRNADPTH PNTNSDAFLS TVDNVYVTSF
     TSSDAGGYYF NGCSFGIIPK K