ID   COLE_ZOPAT              Reviewed;          74 AA.
AC   P80032;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Coleoptericin;
OS   Zophobas atratus (Giant mealworm beetle) (Zophobas rugipes).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Tenebrionidae; Zophobas.
OX   NCBI_TaxID=7074;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Hemolymph;
RX   PubMed=1761552; DOI=10.1016/s0021-9258(18)54260-5;
RA   Bulet P., Cociancich S., Dimarcq J.-L., Lambert J., Reichhart J.-M.,
RA   Hoffmann D., Hetru C., Hoffmann J.A.;
RT   "Insect immunity. Isolation from a coleopteran insect of a novel inducible
RT   antibacterial peptide and of new members of the insect defensin family.";
RL   J. Biol. Chem. 266:24520-24525(1991).
CC   -!- FUNCTION: Responsible for the anti Gram-negative activity of immune
CC       hemolymph of Z.atratus.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the coleoptericin family. {ECO:0000305}.
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DR   PIR; A41711; A41711.
DR   AlphaFoldDB; P80032; -.
DR   PRIDE; P80032; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR009382; Coleoptericin.
DR   Pfam; PF06286; Coleoptericin; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted.
FT   CHAIN           1..74
FT                   /note="Coleoptericin"
FT                   /id="PRO_0000127113"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   74 AA;  8110 MW;  D58E963A1A565630 CRC64;
     SLQGGAPNFP QPSQQNGGWQ VSPDLGRDDK GNTRGQIEIQ NKGKDHDFNA GWGKVIRGPN
     KAKPTWHVGG TYRR