ID   COLI2_CYPCA             Reviewed;         222 AA.
AC   Q9YGK5;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Pro-opiomelanocortin-2;
DE            Short=POMC-2;
DE   AltName: Full=Corticotropin-lipotropin 2;
DE   AltName: Full=Corticotropin-lipotropin II;
DE   AltName: Full=Pro-opiomelanocortin II;
DE            Short=POMC II;
DE   Contains:
DE     RecName: Full=Corticotropin;
DE     AltName: Full=Adrenocorticotropic hormone;
DE              Short=ACTH;
DE   Contains:
DE     RecName: Full=Melanocyte-stimulating hormone alpha;
DE              Short=Alpha-MSH;
DE     AltName: Full=Melanotropin alpha;
DE   Contains:
DE     RecName: Full=Corticotropin-like intermediary peptide;
DE              Short=CLIP;
DE   Contains:
DE     RecName: Full=Lipotropin beta;
DE     AltName: Full=Beta-LPH;
DE   Contains:
DE     RecName: Full=Lipotropin gamma;
DE     AltName: Full=Gamma-LPH;
DE   Contains:
DE     RecName: Full=Melanocyte-stimulating hormone beta;
DE              Short=Beta-MSH;
DE     AltName: Full=Melanotropin beta;
DE   Contains:
DE     RecName: Full=Beta-endorphin;
DE   Contains:
DE     RecName: Full=Met-enkephalin;
DE   Flags: Precursor;
GN   Name=pomcb;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=9806347; DOI=10.1016/s0303-7207(98)00139-7;
RA   Arends R.J., Vermeer H., Martens G.J.M., Leunissen J.A.M.,
RA   Wendelaar Bonga S.E., Flik G.;
RT   "Cloning and expression of two proopiomelanocortin mRNAs in the common carp
RT   (Cyprinus carpio L.).";
RL   Mol. Cell. Endocrinol. 143:23-31(1998).
CC   -!- FUNCTION: [Corticotropin]: Stimulates the adrenal glands to release
CC       cortisol.
CC   -!- FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide.
CC       Increases the pigmentation of skin by increasing melanin production in
CC       melanocytes.
CC   -!- FUNCTION: [Melanocyte-stimulating hormone beta]: Increases the
CC       pigmentation of skin by increasing melanin production in melanocytes.
CC   -!- FUNCTION: [Beta-endorphin]: Endogenous orexigenic opiate.
CC   -!- FUNCTION: [Met-enkephalin]: Endogenous opiate.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
CC       Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored
CC       in separate granules in hypothalamic POMC neurons, suggesting that
CC       secretion may be under the control of different regulatory mechanisms.
CC       {ECO:0000250|UniProtKB:P01193}.
CC   -!- PTM: Specific enzymatic cleavages at paired basic residues yield the
CC       different active peptides.
CC   -!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y14617; CAA74967.1; -; mRNA.
DR   AlphaFoldDB; Q9YGK5; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013531; Mcrtin_ACTH_cent.
DR   InterPro; IPR013593; Melanocortin_N.
DR   InterPro; IPR013532; Opioid_neuropept.
DR   InterPro; IPR001941; PMOC.
DR   Pfam; PF00976; ACTH_domain; 2.
DR   Pfam; PF08384; NPP; 1.
DR   Pfam; PF08035; Op_neuropeptide; 1.
DR   PRINTS; PR00383; MELANOCORTIN.
DR   SMART; SM01363; ACTH_domain; 2.
DR   SMART; SM01364; NPP; 1.
DR   SMART; SM01365; Op_neuropeptide; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Endorphin; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   PROPEP          29..105
FT                   /id="PRO_0000025066"
FT   PEPTIDE         108..146
FT                   /note="Corticotropin"
FT                   /id="PRO_0000025067"
FT   PEPTIDE         108..122
FT                   /note="Melanocyte-stimulating hormone alpha"
FT                   /id="PRO_0000025068"
FT   PEPTIDE         126..146
FT                   /note="Corticotropin-like intermediary peptide"
FT                   /id="PRO_0000025069"
FT   PEPTIDE         149..222
FT                   /note="Lipotropin beta"
FT                   /id="PRO_0000025070"
FT   PEPTIDE         149..187
FT                   /note="Lipotropin gamma"
FT                   /id="PRO_0000025071"
FT   PEPTIDE         171..187
FT                   /note="Melanocyte-stimulating hormone beta"
FT                   /id="PRO_0000025072"
FT   PEPTIDE         190..222
FT                   /note="Beta-endorphin"
FT                   /id="PRO_0000025073"
FT   PEPTIDE         190..194
FT                   /note="Met-enkephalin"
FT                   /id="PRO_0000025074"
SQ   SEQUENCE   222 AA;  25385 MW;  DDEA886E3D6A8AE8 CRC64;
     MVRGVRMLCP AWLLALAVLC AGGSEVRAQC WEDARCRDLT TDENILNCIQ LCRSDLTDET
     PVYPGESHLQ PPSELEQAEV LEPLSPAALA PAEQMDPESS PRHELKRSYS MEHFRWGKPV
     GRKRRPIKVY TNGVEEESAE SLPAEMRREL ATNEVNHPQE DSALIQQKKK DGSYKMKHFR
     WSSPPAGKRY GGFMKSWDER SQKPLLTLFK NVINKEHQKK DQ