ID   COLI_BALBO              Reviewed;          39 AA.
AC   P68000; P01195;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Pro-opiomelanocortin;
DE            Short=POMC;
DE   AltName: Full=Corticotropin-lipotropin;
DE   Contains:
DE     RecName: Full=Corticotropin;
DE     AltName: Full=Adrenocorticotropic hormone;
DE              Short=ACTH;
DE   Contains:
DE     RecName: Full=Melanocyte-stimulating hormone alpha;
DE              Short=Alpha-MSH;
DE     AltName: Full=Melanotropin alpha;
DE   Contains:
DE     RecName: Full=Corticotropin-like intermediary peptide;
DE              Short=CLIP;
DE   Flags: Fragment;
GN   Name=POMC;
OS   Balaenoptera borealis (Sei whale) (Pollack whale).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti;
OC   Balaenopteridae; Balaenoptera.
OX   NCBI_TaxID=9768;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=201308;
RA   Pankov Y.A., Nikolaeva O.P., Elizarova G.P.;
RT   "Amino acid sequence of corticotropins from seiwhale (Balaenoptera
RT   borealis) and pinwhale (Balaenoptera physalus).";
RL   Biokhimiia 42:2044-2050(1977).
CC   -!- FUNCTION: Precursor protein for pituitary hormones that regulate stress
CC       and environmental adaptation.
CC   -!- FUNCTION: [Corticotropin]: Stimulates the adrenal glands to release
CC       cortisol.
CC   -!- FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide.
CC       Increases the pigmentation of skin by increasing melanin production in
CC       melanocytes.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
CC   -!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
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DR   PIR; PN0127; PN0127.
DR   AlphaFoldDB; P68000; -.
DR   SMR; P68000; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013531; Mcrtin_ACTH_cent.
DR   InterPro; IPR001941; PMOC.
DR   Pfam; PF00976; ACTH_domain; 1.
DR   PRINTS; PR00383; MELANOCORTIN.
DR   SMART; SM01363; ACTH_domain; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Amidation; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Hormone; Phosphoprotein; Secreted.
FT   PEPTIDE         1..39
FT                   /note="Corticotropin"
FT                   /id="PRO_0000024937"
FT   PEPTIDE         1..13
FT                   /note="Melanocyte-stimulating hormone alpha"
FT                   /id="PRO_0000024938"
FT   PEPTIDE         19..39
FT                   /note="Corticotropin-like intermediary peptide"
FT                   /id="PRO_0000024939"
FT   MOD_RES         1
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01191"
FT   MOD_RES         13
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P01190"
FT   MOD_RES         31
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01189"
FT   NON_TER         1
FT   NON_TER         39
SQ   SEQUENCE   39 AA;  4541 MW;  461FD46C28945A6E CRC64;
     SYSMEHFRWG KPVGKKRRPV KVYPNGAEDE SAEAFPLEF