COLI_LITCT
ID COLI_LITCT Reviewed; 263 AA.
AC P11885;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Pro-opiomelanocortin;
DE Short=POMC;
DE AltName: Full=Corticotropin-lipotropin;
DE Contains:
DE RecName: Full=NPP;
DE Contains:
DE RecName: Full=Melanotropin gamma;
DE AltName: Full=Gamma-MSH;
DE Contains:
DE RecName: Full=Corticotropin;
DE AltName: Full=Adrenocorticotropic hormone;
DE Short=ACTH;
DE Contains:
DE RecName: Full=Melanocyte-stimulating hormone alpha;
DE Short=Alpha-MSH;
DE AltName: Full=Melanotropin alpha;
DE Contains:
DE RecName: Full=Corticotropin-like intermediary peptide;
DE Short=CLIP;
DE Contains:
DE RecName: Full=Lipotropin beta;
DE AltName: Full=Beta-LPH;
DE Contains:
DE RecName: Full=Lipotropin gamma;
DE AltName: Full=Gamma-LPH;
DE Contains:
DE RecName: Full=Melanocyte-stimulating hormone beta;
DE Short=Beta-MSH;
DE AltName: Full=Melanotropin beta;
DE Contains:
DE RecName: Full=Beta-endorphin;
DE Contains:
DE RecName: Full=Met-enkephalin;
DE Flags: Precursor;
GN Name=pomc;
OS Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX NCBI_TaxID=8400;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2788269; DOI=10.1093/nar/17.14.5843;
RA Pan F.-M., Chang W.-C.;
RT "Nucleotide sequence of bullfrog pro-opiomelanocortin cDNA.";
RL Nucleic Acids Res. 17:5843-5843(1989).
RN [2]
RP PROTEIN SEQUENCE OF 30-74 AND 107-141.
RC TISSUE=Pituitary;
RX PubMed=1331997; DOI=10.1016/0196-9781(92)90179-7;
RA Iwamuro S., Hayashi H., Delbende C., Vaudry H., Kikuyama S.;
RT "Purification and characterization of joining peptide and N-terminal
RT peptide of proopiomelanocortin from the pars distalis of the bullfrog
RT pituitary.";
RL Peptides 13:729-735(1992).
CC -!- FUNCTION: [Corticotropin]: Stimulates the adrenal glands to release
CC cortisol.
CC -!- FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide.
CC Increases the pigmentation of skin by increasing melanin production in
CC melanocytes.
CC -!- FUNCTION: [Melanocyte-stimulating hormone beta]: Increases the
CC pigmentation of skin by increasing melanin production in melanocytes.
CC -!- FUNCTION: [Beta-endorphin]: Endogenous orexigenic opiate.
CC -!- FUNCTION: [Met-enkephalin]: Endogenous opiate.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
CC Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored
CC in separate granules in hypothalamic POMC neurons, suggesting that
CC secretion may be under the control of different regulatory mechanisms.
CC {ECO:0000250|UniProtKB:P01193}.
CC -!- PTM: Specific enzymatic cleavages at paired basic residues yield the
CC different active peptides.
CC -!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X15510; CAA33530.1; -; mRNA.
DR PIR; S05433; S05433.
DR AlphaFoldDB; P11885; -.
DR SMR; P11885; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR013531; Mcrtin_ACTH_cent.
DR InterPro; IPR013593; Melanocortin_N.
DR InterPro; IPR013532; Opioid_neuropept.
DR InterPro; IPR001941; PMOC.
DR Pfam; PF00976; ACTH_domain; 3.
DR Pfam; PF08384; NPP; 1.
DR Pfam; PF08035; Op_neuropeptide; 1.
DR PRINTS; PR00383; MELANOCORTIN.
DR SMART; SM01363; ACTH_domain; 3.
DR SMART; SM01364; NPP; 1.
DR SMART; SM01365; Op_neuropeptide; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Endorphin; Glycoprotein; Hormone; Pyrrolidone carboxylic acid; Secreted;
KW Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PEPTIDE 27..104
FT /note="NPP"
FT /evidence="ECO:0000250"
FT /id="PRO_0000025122"
FT PEPTIDE 77..87
FT /note="Melanotropin gamma"
FT /evidence="ECO:0000250"
FT /id="PRO_0000025123"
FT PROPEP 107..141
FT /id="PRO_0000025124"
FT PEPTIDE 144..182
FT /note="Corticotropin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000025125"
FT PEPTIDE 144..156
FT /note="Melanocyte-stimulating hormone alpha"
FT /evidence="ECO:0000250"
FT /id="PRO_0000025126"
FT PEPTIDE 162..182
FT /note="Corticotropin-like intermediary peptide"
FT /evidence="ECO:0000250"
FT /id="PRO_0000025127"
FT PEPTIDE 185..263
FT /note="Lipotropin beta"
FT /evidence="ECO:0000250"
FT /id="PRO_0000025128"
FT PEPTIDE 185..230
FT /note="Lipotropin gamma"
FT /evidence="ECO:0000250"
FT /id="PRO_0000025129"
FT PEPTIDE 214..230
FT /note="Melanocyte-stimulating hormone beta"
FT /evidence="ECO:0000250"
FT /id="PRO_0000025130"
FT PEPTIDE 233..263
FT /note="Beta-endorphin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000025131"
FT PEPTIDE 233..237
FT /note="Met-enkephalin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000025132"
FT MOD_RES 27
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 87
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT MOD_RES 156
FT /note="Valine amide"
FT /evidence="ECO:0000250"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 67
FT /note="I -> M (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="L -> P (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="D -> E (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 263 AA; 30389 MW; CC09C6608AD0B67A CRC64;
MLQPVWHACI LAILGVFIFH VGEVRSQCWE SNKCTDLSSE DGILECIKAC KMDLSAESPV
FPGNGHIQPL SENIRKYVMS HFRWNKFGRR NSTSNDNNNN NGGYKREDIA NYPILNLFLG
SDNQNTQEGI MEDDALDRQD SKRSYSMEHF RWGKPVGKKR RPIKVFPTDA EEESSESFPI
ELRRELSLEF DYPDTNSEEE LDNGELLEGP VKKGRKYKMH HFRWEGPPKD KRYGGFMTPE
RSQTPLMTLF KNAIIKNAHK KGQ
