ID   COLI_NEOVI              Reviewed;         142 AA.
AC   P11280;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Pro-opiomelanocortin;
DE            Short=POMC;
DE   AltName: Full=Corticotropin-lipotropin;
DE   Contains:
DE     RecName: Full=Corticotropin;
DE     AltName: Full=Adrenocorticotropic hormone;
DE              Short=ACTH;
DE   Contains:
DE     RecName: Full=Melanocyte-stimulating hormone alpha;
DE              Short=Alpha-MSH;
DE     AltName: Full=Melanotropin alpha;
DE   Contains:
DE     RecName: Full=Corticotropin-like intermediary peptide;
DE              Short=CLIP;
DE   Contains:
DE     RecName: Full=Lipotropin beta;
DE     AltName: Full=Beta-LPH;
DE   Contains:
DE     RecName: Full=Lipotropin gamma;
DE     AltName: Full=Gamma-LPH;
DE   Contains:
DE     RecName: Full=Melanocyte-stimulating hormone beta;
DE              Short=Beta-MSH;
DE     AltName: Full=Melanotropin beta;
DE   Contains:
DE     RecName: Full=Beta-endorphin;
DE   Contains:
DE     RecName: Full=Met-enkephalin;
DE   Flags: Precursor; Fragment;
GN   Name=POMC;
OS   Neovison vison (American mink) (Mustela vison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
OC   Neogale.
OX   NCBI_TaxID=452646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3397057; DOI=10.1016/0888-7543(88)90001-8;
RA   Khlebodarova T.M., Karasik G.I., Matveeva N.M., Serov O.L., Golovin S.Y.,
RA   Bondar A.A., Karginov V.A., Morozov I.S., Zelenin S.M., Mertvetsov N.P.;
RT   "The mink proopiomelanocortin gene: characterization of cDNA and
RT   chromosomal localization.";
RL   Genomics 2:185-188(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3382437;
RA   Golovin S.Y., Bondar A.A., Karginov V.A., Morosov I.V., Zelenin S.M.,
RA   Popova V.C., Mertvetsov N.P.;
RT   "Synthesis, cloning and primary structure of cDNA for proopiomelanocortin
RT   from the pituitary gland of the mink (Mustella vison).";
RL   Bioorg. Khim. 14:273-275(1988).
CC   -!- FUNCTION: [Corticotropin]: Stimulates the adrenal glands to release
CC       cortisol.
CC   -!- FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide.
CC       Increases the pigmentation of skin by increasing melanin production in
CC       melanocytes.
CC   -!- FUNCTION: [Melanocyte-stimulating hormone beta]: Increases the
CC       pigmentation of skin by increasing melanin production in melanocytes.
CC   -!- FUNCTION: [Beta-endorphin]: Endogenous orexigenic opiate.
CC   -!- FUNCTION: [Met-enkephalin]: Endogenous opiate.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
CC       Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored
CC       in separate granules in hypothalamic POMC neurons, suggesting that
CC       secretion may be under the control of different regulatory mechanisms.
CC       {ECO:0000250|UniProtKB:P01193}.
CC   -!- TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary gland.
CC   -!- PTM: Specific enzymatic cleavages at paired basic residues yield the
CC       different active peptides.
CC   -!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
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DR   EMBL; J03039; AAA30967.1; -; mRNA.
DR   PIR; A29976; A29976.
DR   AlphaFoldDB; P11280; -.
DR   SMR; P11280; -.
DR   Proteomes; UP000694425; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013531; Mcrtin_ACTH_cent.
DR   InterPro; IPR013532; Opioid_neuropept.
DR   InterPro; IPR001941; PMOC.
DR   Pfam; PF00976; ACTH_domain; 2.
DR   Pfam; PF08035; Op_neuropeptide; 1.
DR   PRINTS; PR00383; MELANOCORTIN.
DR   SMART; SM01363; ACTH_domain; 2.
DR   SMART; SM01365; Op_neuropeptide; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Endorphin; Hormone;
KW   Phosphoprotein; Reference proteome; Secreted.
FT   PROPEP          <1..8
FT                   /id="PRO_0000045867"
FT   PEPTIDE         11..49
FT                   /note="Corticotropin"
FT                   /id="PRO_0000025007"
FT   PEPTIDE         11..23
FT                   /note="Melanocyte-stimulating hormone alpha"
FT                   /id="PRO_0000025008"
FT   PEPTIDE         29..49
FT                   /note="Corticotropin-like intermediary peptide"
FT                   /id="PRO_0000025009"
FT   PEPTIDE         52..142
FT                   /note="Lipotropin beta"
FT                   /id="PRO_0000025010"
FT   PEPTIDE         52..109
FT                   /note="Lipotropin gamma"
FT                   /id="PRO_0000025011"
FT   PEPTIDE         92..109
FT                   /note="Melanocyte-stimulating hormone beta"
FT                   /id="PRO_0000025012"
FT   PEPTIDE         112..142
FT                   /note="Beta-endorphin"
FT                   /id="PRO_0000025013"
FT   PEPTIDE         112..116
FT                   /note="Met-enkephalin"
FT                   /id="PRO_0000025014"
FT   MOD_RES         23
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         41
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P01189"
FT   NON_TER         1
SQ   SEQUENCE   142 AA;  15822 MW;  066E7AD791C26BB0 CRC64;
     SEPGRREGKR SYSMEHFRWG KPVGKKRRPV KVYPNGAEDE SAEAFPLEFK RELAGERPEP
     ALGPEGAAEG MAALADLEYG LVAKAEVAEK KDDGPYKMEH FRWGSPGKDK RYGGFMTSEK
     SQTPLVTLFK NAIIKNAHKK GQ