COLI_ONCKE
ID COLI_ONCKE Reviewed; 226 AA.
AC P10000; P01199; P01204; P87470; P87471; P87472; P87473; P87474; P87475;
AC P87476; P87477; P87478; Q90521; Q92024;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 2.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Pro-opiomelanocortin;
DE Short=POMC;
DE AltName: Full=Corticotropin-lipotropin;
DE Contains:
DE RecName: Full=Corticotropin;
DE AltName: Full=Adrenocorticotropic hormone;
DE Short=ACTH;
DE Contains:
DE RecName: Full=Melanocyte-stimulating hormone alpha;
DE Short=Alpha-MSH;
DE AltName: Full=Melanotropin alpha;
DE Contains:
DE RecName: Full=Corticotropin-like intermediary peptide;
DE Short=CLIP;
DE Contains:
DE RecName: Full=Lipotropin beta;
DE AltName: Full=Beta-LPH;
DE Contains:
DE RecName: Full=Lipotropin gamma;
DE AltName: Full=Gamma-LPH;
DE Contains:
DE RecName: Full=Melanocyte-stimulating hormone beta;
DE Short=Beta-MSH;
DE AltName: Full=Melanotropin beta;
DE Contains:
DE RecName: Full=Beta-endorphin;
DE Contains:
DE RecName: Full=Met-enkephalin;
DE Flags: Precursor;
GN Name=pomc;
OS Oncorhynchus keta (Chum salmon) (Salmo keta).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8018;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3197404; DOI=10.1016/0305-0491(88)90155-1;
RA Kitahara N., Nishizawa T., Iida K., Okazaki H., Andoh T., Soma G.;
RT "Absence of a gamma-melanocyte-stimulating hormone sequence in
RT proopiomelanocortin mRNA of chum salmon Oncorhynchus keta.";
RL Comp. Biochem. Physiol. 91B:365-370(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 92-226.
RX PubMed=6095185; DOI=10.1093/nar/12.21.8029;
RA Soma G., Kitahara N., Nishizawa T., Nanami H., Kotake C., Okazaki H.,
RA Andoh T.;
RT "Nucleotide sequence of a cloned cDNA for proopiomelanocortin precursor of
RT chum salmon, Onchorynchus keta.";
RL Nucleic Acids Res. 12:8029-8041(1984).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 92-226.
RX PubMed=6087806; DOI=10.1016/s0006-291x(84)80069-8;
RA Nishizawa T., Kitahara N., Nanami H., Hara N., Kotake C., Okazaki H.,
RA Andoh T., Soma G.;
RT "Heterogeneity of 3' nontranslated regions in proopiomelanocortin (POMC)
RT precursor mRNA of chum salmon Onchorynchus keta: polymorphism of the
RT gene.";
RL Biochem. Biophys. Res. Commun. 122:556-562(1984).
RN [4]
RP PROTEIN SEQUENCE OF 98-112, AND ACETYLATION AT SER-98.
RX PubMed=7447938; DOI=10.1016/0006-291x(80)91345-5;
RA Kawauchi H., Adachi Y., Tsubokawa M.;
RT "Occurrence of a new melanocyte stimulating hormone in the salmon pituitary
RT gland.";
RL Biochem. Biophys. Res. Commun. 96:1508-1517(1980).
RN [5]
RP PROTEIN SEQUENCE OF 198-226, AND ACETYLATION AT TYR-198.
RX PubMed=475783; DOI=10.1016/0006-291x(79)91114-8;
RA Kawauchi H., Tsubokawa M., Muramoto K.;
RT "Isolation and primary structure of endorphin from salmon pituitary
RT glands.";
RL Biochem. Biophys. Res. Commun. 88:1249-1254(1979).
CC -!- FUNCTION: [Corticotropin]: Stimulates the adrenal glands to release
CC cortisol.
CC -!- FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide.
CC Increases the pigmentation of skin by increasing melanin production in
CC melanocytes.
CC -!- FUNCTION: [Melanocyte-stimulating hormone beta]: Increases the
CC pigmentation of skin by increasing melanin production in melanocytes.
CC -!- FUNCTION: [Beta-endorphin]: Endogenous orexigenic opiate.
CC -!- FUNCTION: [Met-enkephalin]: Endogenous opiate.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
CC Note=Melanocyte-stimulating hormone alpha and beta-endorphin are stored
CC in separate granules in hypothalamic POMC neurons, suggesting that
CC secretion may be under the control of different regulatory mechanisms.
CC {ECO:0000250|UniProtKB:P01193}.
CC -!- PTM: Specific enzymatic cleavages at paired basic residues yield the
CC different active peptides.
CC -!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA49426.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M27692; AAA49426.1; ALT_INIT; mRNA.
DR EMBL; K02613; AAA49424.1; -; mRNA.
DR EMBL; K02614; AAA49425.1; -; mRNA.
DR EMBL; X01122; CAA25591.1; -; mRNA.
DR PIR; I51080; CTONPK.
DR AlphaFoldDB; P10000; -.
DR iPTMnet; P10000; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR013531; Mcrtin_ACTH_cent.
DR InterPro; IPR013593; Melanocortin_N.
DR InterPro; IPR013532; Opioid_neuropept.
DR InterPro; IPR001941; PMOC.
DR Pfam; PF00976; ACTH_domain; 2.
DR Pfam; PF08384; NPP; 1.
DR Pfam; PF08035; Op_neuropeptide; 1.
DR PRINTS; PR00383; MELANOCORTIN.
DR SMART; SM01363; ACTH_domain; 2.
DR SMART; SM01364; NPP; 1.
DR SMART; SM01365; Op_neuropeptide; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Endorphin; Hormone; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..97
FT /evidence="ECO:0000255"
FT /id="PRO_0000025083"
FT PEPTIDE 98..138
FT /note="Corticotropin"
FT /id="PRO_0000025084"
FT PEPTIDE 98..112
FT /note="Melanocyte-stimulating hormone alpha"
FT /evidence="ECO:0000269|PubMed:7447938"
FT /id="PRO_0000025085"
FT PEPTIDE 116..138
FT /note="Corticotropin-like intermediary peptide"
FT /id="PRO_0000025086"
FT PEPTIDE 141..226
FT /note="Lipotropin beta"
FT /id="PRO_0000025087"
FT PEPTIDE 141..195
FT /note="Lipotropin gamma"
FT /id="PRO_0000025088"
FT PEPTIDE 179..195
FT /note="Melanocyte-stimulating hormone beta"
FT /id="PRO_0000025089"
FT PEPTIDE 198..226
FT /note="Beta-endorphin"
FT /evidence="ECO:0000269|PubMed:475783"
FT /id="PRO_0000025090"
FT PEPTIDE 198..202
FT /note="Met-enkephalin"
FT /evidence="ECO:0000269|PubMed:475783"
FT /id="PRO_0000025091"
FT MOD_RES 98
FT /note="N-acetylserine; in Corticotropin"
FT /evidence="ECO:0000269|PubMed:7447938"
FT MOD_RES 198
FT /note="N-acetyltyrosine; in Beta-endorphin and Met-
FT enkephalin"
FT /evidence="ECO:0000269|PubMed:475783"
SQ SEQUENCE 226 AA; 24982 MW; 327CA785F69B1B24 CRC64;
MVCAPWLLAV VVVCVCNPGV GGQCWDSSHC KDLPSEDKIL ECTHLFRSGL QDESPEPRSA
AQQSTEESLS LGILLAALTS GERALDADPE PHSDKRHSYS MEHFRWGKPI GHKRRPIKVY
ASSLEGGDSS EGTFPLQARR QLGSWEDEMV GALGNQGAKA QTKVVPRTLT VTGLQDKKDG
SYRMGHFRWG SPTAIKRYGG FMKPYTKQSH KPLITLLKHI TLKNEQ
