ID   COLI_SQUAC              Reviewed;          39 AA.
AC   P01197;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Pro-opiomelanocortin;
DE            Short=POMC;
DE   AltName: Full=Corticotropin-lipotropin;
DE   Contains:
DE     RecName: Full=Corticotropin;
DE     AltName: Full=Adrenocorticotropic hormone;
DE              Short=ACTH;
DE   Contains:
DE     RecName: Full=Melanocyte-stimulating hormone alpha;
DE              Short=Alpha-MSH;
DE     AltName: Full=Melanotropin alpha;
DE   Contains:
DE     RecName: Full=Corticotropin-like intermediary peptide;
DE              Short=CLIP;
DE   Flags: Fragment;
GN   Name=pomc;
OS   Squalus acanthias (Spiny dogfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Squalomorphii; Squaliformes; Squalidae; Squalus.
OX   NCBI_TaxID=7797;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=4375977; DOI=10.1042/bj1410427;
RA   Lowry P.J., Bennett H.P.J., McMartin C., Scott A.P.;
RT   "The isolation and amino acid sequence of an adrenocorticotrophin from the
RT   pars distalis and a corticotrophin-like intermediate-lobe peptide from the
RT   neurointermediate lobe of the pituitary of the dogfish Squalus acanthias.";
RL   Biochem. J. 141:427-437(1974).
RN   [2]
RP   PROTEIN SEQUENCE OF 3-13.
RX   PubMed=5476715; DOI=10.1042/bj1180713;
RA   Lowry P.J., Chadwick A.;
RT   "Purification and amino acid sequence of melanocyte-stimulating hormone
RT   from the dogfish Squalus acanthias.";
RL   Biochem. J. 118:713-718(1970).
RN   [3]
RP   SEQUENCE REVISION, AND AMIDATION AT MET-13.
RX   PubMed=4375978; DOI=10.1042/bj1410439;
RA   Bennett H.P.J., Lowry P.J., McMartin C., Scott A.P.;
RT   "Structural studies of alpha-melanocyte-stimulating hormone and a novel
RT   beta-melanocyte-stimulating hormone from the neurointermediate lobe of the
RT   pituitary of the dogfish Squalus acanthias.";
RL   Biochem. J. 141:439-444(1974).
CC   -!- FUNCTION: Precursor protein for pituitary hormones that regulate stress
CC       and environmental adaptation.
CC   -!- FUNCTION: [Corticotropin]: Stimulates the adrenal glands to release
CC       cortisol.
CC   -!- FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide.
CC       Increases the pigmentation of skin by increasing melanin production in
CC       melanocytes.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
CC       Note=Alpha-MSH and beta-endorphin are stored in separate granules in
CC       hypothalamic POMC neurons, suggesting that secretion may be under the
CC       control of different regulatory mechanisms.
CC       {ECO:0000250|UniProtKB:P01193}.
CC   -!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
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DR   PIR; A90276; CTDFAS.
DR   AlphaFoldDB; P01197; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013531; Mcrtin_ACTH_cent.
DR   InterPro; IPR001941; PMOC.
DR   Pfam; PF00976; ACTH_domain; 1.
DR   PRINTS; PR00383; MELANOCORTIN.
DR   SMART; SM01363; ACTH_domain; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Secreted.
FT   PEPTIDE         1..39
FT                   /note="Corticotropin"
FT                   /id="PRO_0000025144"
FT   PEPTIDE         1..13
FT                   /note="Melanocyte-stimulating hormone alpha"
FT                   /evidence="ECO:0000269|PubMed:4375977"
FT                   /id="PRO_0000025145"
FT   PEPTIDE         19..39
FT                   /note="Corticotropin-like intermediary peptide"
FT                   /id="PRO_0000025146"
FT   MOD_RES         13
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:4375978"
FT   NON_TER         1
FT   NON_TER         39
SQ   SEQUENCE   39 AA;  4686 MW;  4B6E5794F6D78E71 CRC64;
     SYSMEHFRWG KPMGRKRRPI KVYPNSFEDE SVENMGPEL