ID   COLI_STRCA              Reviewed;          39 AA.
AC   P01196;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Pro-opiomelanocortin;
DE            Short=POMC;
DE   Contains:
DE     RecName: Full=Corticotropin;
DE     AltName: Full=Adrenocorticotropic hormone;
DE              Short=ACTH;
DE   Contains:
DE     RecName: Full=Melanocyte-stimulating hormone alpha;
DE              Short=Alpha-MSH;
DE     AltName: Full=Melanotropin alpha;
DE   Contains:
DE     RecName: Full=Corticotropin-like intermediary peptide;
DE              Short=CLIP;
DE   Flags: Fragment;
GN   Name=POMC;
OS   Struthio camelus (Common ostrich).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC   Struthio.
OX   NCBI_TaxID=8801;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=208539; DOI=10.1016/0006-291x(78)91436-5;
RA   Li C.H., Chung D., Oelofsen W., Naude R.J.;
RT   "Adrenocorticotropin 53. The amino acid sequence of the hormone from the
RT   ostrich pituitary gland.";
RL   Biochem. Biophys. Res. Commun. 81:900-906(1978).
CC   -!- FUNCTION: Precursor protein for pituitary hormones that regulate stress
CC       and environmental adaptation.
CC   -!- FUNCTION: [Corticotropin]: Stimulates the adrenal glands to release
CC       cortisol.
CC   -!- FUNCTION: [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide.
CC       Increases the pigmentation of skin by increasing melanin production in
CC       melanocytes.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01193}.
CC       Note=Alpha-MSH and beta-endorphin are stored in separate granules in
CC       hypothalamic POMC neurons, suggesting that secretion may be under the
CC       control of different regulatory mechanisms.
CC       {ECO:0000250|UniProtKB:P01193}.
CC   -!- SIMILARITY: Belongs to the POMC family. {ECO:0000305}.
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DR   PIR; A01459; A01459.
DR   AlphaFoldDB; P01196; -.
DR   SMR; P01196; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR013531; Mcrtin_ACTH_cent.
DR   InterPro; IPR001941; PMOC.
DR   Pfam; PF00976; ACTH_domain; 1.
DR   PRINTS; PR00383; MELANOCORTIN.
DR   SMART; SM01363; ACTH_domain; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Hormone; Secreted.
FT   PEPTIDE         1..39
FT                   /note="Corticotropin"
FT                   /id="PRO_0000025147"
FT   PEPTIDE         1..13
FT                   /note="Melanocyte-stimulating hormone alpha"
FT                   /id="PRO_0000025148"
FT   PEPTIDE         19..39
FT                   /note="Corticotropin-like intermediary peptide"
FT                   /id="PRO_0000025149"
FT   MOD_RES         13
FT                   /note="Valine amide"
FT                   /evidence="ECO:0000250|UniProtKB:P01190"
FT   NON_TER         1
FT   NON_TER         39
SQ   SEQUENCE   39 AA;  4626 MW;  02555C387E1AFA76 CRC64;
     SYSMEHFRWG KPVGRKRRPV KVYPNGVQEE TSEGFPLEF